2021
DOI: 10.1515/cclm-2021-1011
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Age-adapted percentiles of measured glomerular filtration in healthy individuals: extrapolation to living kidney donors over 65 years

Abstract: Objectives Most data on glomerular filtration rate (GFR) originate from subjects <65 years old, complicating decision-making in elderly living kidney donors. In this retrospective multi-center study, we calculated percentiles of measured GFR (mGFR) in donors <65 years old and extrapolated these to donors ≥65 years old. Methods mGFR percentiles were calculated from a development cohort of French/Belgian living kidney don… Show more

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Cited by 8 publications
(4 citation statements)
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References 27 publications
(55 reference statements)
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“…Kidney senescence has been well described at the cellular and microscopic levels, with a distinction between the microstructural changes observed in normal physiologic aging versus in diseases (1,2). The effect of kidney senescence on GFR has been relatively well described but mainly from cross-sectional data, which are not ideal from a methodologic point of view (1,35). After a period of kidney maturation in the first years of life, GFR remains constant until around 40 years.…”
mentioning
confidence: 99%
“…Kidney senescence has been well described at the cellular and microscopic levels, with a distinction between the microstructural changes observed in normal physiologic aging versus in diseases (1,2). The effect of kidney senescence on GFR has been relatively well described but mainly from cross-sectional data, which are not ideal from a methodologic point of view (1,35). After a period of kidney maturation in the first years of life, GFR remains constant until around 40 years.…”
mentioning
confidence: 99%
“…Indeed, the significantly increased risk of physical frailty and mortality in older CKD patients [7,11,14,17,27,46,47,54,55]. However, the current KDIGO guidelines from 2012 do not take age into account when classifying the severity of CKD, although current research shows that from an age of about 45 years, the eGFR physiologically decreases by ~0.88 mL/min/1.73 m 2 /year [56]. This is particularly important because at the moment kidney aging is not relevantly differentiated from kidney disease, just as the severity of CKD in old age may be overestimated.…”
Section: Discussionmentioning
confidence: 99%
“…It is true that, at the population level, median serum creatinine values only slightly increase with aging [ 31 ]. However, GFR is stable until 40 years of age and only physiologically declines with aging beyond 40 years, and thus, age in the CKD-EPI 2009 equation does not adequately reflect the way GFR evolves with age [ 12 , 32 ]. So, this method of modeling the association between creatinine, GFR and age in the CKD-EPI equation is an over-simplification [ 33–36 ].…”
Section: A Short History Of Creatinine-based Equationsmentioning
confidence: 99%