Agarwood Pill Enhances Immune Function in Cyclophosphamide-induced Immunosuppressed Mice

Ji, Seon Yeong; Lee, Hyesook; Hwangbo, Hyun; Kim, Min Yeong; Kim, Da Hye; Park, Beom Su; Koo, Young Tae; Lee, Ki Won; Ko, Jong Cheul; Kim, Gi‐Young; Bang, EunJin; Choi, Yung Hyun

doi:10.1007/s12257-022-0345-9

Cited by 4 publications

(2 citation statements)

References 45 publications

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“…This observation suggests that Cy caused splenomegaly in mice. These results are consistent with previous findings [ 25 ]. The spleen index of immunosuppressed mice significantly decreased with different doses of EVPA.…”

Section: Resultssupporting

confidence: 94%

Microbiome–Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of Vanilla planifolia Andrew (EVPA) on Immunosuppressed Mice

Zhang,

Li,

Zhu

et al. 2024

Foods

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This study investigated the immunoprotective effects of the extract of Vanilla planifolia Andrew (EVPA) on cyclophosphamide (Cy)-induced immunosuppression in mice. The results show that EVPA administration significantly alleviated the immune damage induced by Cy, as evidenced by an improved body weight, organ index, and colonic injury. A further analysis of microbial diversity revealed that the EVPA primarily increased the abundance of the beneficial bacteria Verrucomicrobiota, Lactobacillaceae, and Lactobacillus while decreasing Akkermansiaceae, Akkermansia, Romboutsia, and Lactococcus, thereby ameliorating the microbial dysbiosis caused by Cy. A metabolomic analysis revealed significant alterations in the microbial metabolite levels after EVPA treatment, including urobilinogen, formamidopyrimidine nucleoside triphosphate, Cer (d18:1/18:0), pantetheine, and LysoPC (15:0/0:0). These altered metabolites are associated with pathways related to sphingolipid metabolism, carbapenem biosynthesis, pantothenate and CoA biosynthesis, glycerophospholipid metabolism, and porphyrin metabolism. Furthermore, significant correlations were observed between certain microbial groups and the differential metabolites. These findings provide new insights into the immunomodulatory effects of EVPA on the intestinal microbiota and metabolism, laying the foundation for more extensive utilization.

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Section: Resultssupporting

confidence: 94%

Microbiome–Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of Vanilla planifolia Andrew (EVPA) on Immunosuppressed Mice

Zhang,

Li,

Zhu

et al. 2024

Foods

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“…The pesticide exposure of living systems has been shown to hinder the liver functions and to cause damage to liver and brain tissue [ 39 ]. The application of phytochemicals extracted from plants as a therapeutic companion has been shown to contain great promise in this context [ 40 , 41 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats

Gupta,

Park,

Siddiqi

et al. 2023

Toxics

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Pesticide exposure can pose a serious risk to nontarget animals. Cartap is being broadly used in agricultural fields. The toxic effects of cartap on the levels of hepatotoxicity and neurotoxicity have not been properly studied in mammalian systems. Therefore, the present work focused on the effect of cartap on the liver and brain of Wistar rats and made an assessment of the ameliorating potential of A. vera. The experimental animals were divided into 4 groups, comprising six rats in each: Group 1—Control; Group 2—A. vera; Group 3—Cartap; and Group 4—A. vera + Cartap. The animals orally given cartap and A. vera were sacrificed after 24 h of the final treatment and histological and biochemical investigations were conducted in liver and brain of Wistar rats. Cartap at sublethal concentrations caused substantial decreases in CAT, SOD, and GST levels in the experimental rats. The activity levels of transaminases and phosphatases in cartap group were also found to be substantially altered. The AChE activity was recorded as decreasing in RBC membrane and brain of the cartap-treated animals. The TNF-α and IL-6 level in serum were increased expressively in the cartap challenged groups. Histological investigation of liver showed disorganized hepatic cords and severely congested central veins due to cartap. However, the A. vera extract was observed to significantly protect against the effects of cartap toxicity. The protective impact of A. vera against cartap toxicity may be due to the existence of antioxidants in it. These findings suggest that A. vera may be developed as a potential supplement to the appropriate medication in the treatment of cartap toxicity.

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The latest techniques for inducing macrophage differentiation

Lee,

Choi,

Kim

et al. 2024

Biotechnol Bioproc E

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Agarwood Pill Enhances Immune Function in Cyclophosphamide-induced Immunosuppressed Mice

Cited by 4 publications

References 45 publications

Microbiome–Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of Vanilla planifolia Andrew (EVPA) on Immunosuppressed Mice

Microbiome–Metabolomic Analysis Revealed the Immunoprotective Effects of the Extract of Vanilla planifolia Andrew (EVPA) on Immunosuppressed Mice

Amelioration of Hepatotoxic and Neurotoxic Effect of Cartap by Aloe vera in Wistar Rats

The latest techniques for inducing macrophage differentiation

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