Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review

Guastaferro, Mariangela; Reverchon, Ernesto; Baldino, Lucia

doi:10.3389/fbioe.2021.688477

Cited by 39 publications

(14 citation statements)

References 114 publications

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“…Aerogels have a large surface area, porous structure, and ultra‐low density, making them ideal candidates for a wide range of applications. Aerogels have been used for thermal insulation (Noroozi et al., 2019), packaging (Manzocco et al., 2021), fillers (Halim et al., 2020), biosensors (Gao & Wen, 2021), separation technologies (Wang & Wang, 2019), space applications (Maleki et al., 2014), tissue engineering (Baldino et al., 2019; Berrio et al., 2021), and drug delivery (García‐González et al., 2021; Guastaferro et al., 2021). SC‐CO 2 drying preserves the original gel structure and generates nanoporous materials with high surface area that are not possible with conventional drying technologies such as air‐ and freeze‐drying (Ciftci et al., 2017; Ubeyitogullari & Ciftci, 2016a).…”

Section: Porous Biopolymer Fabrication Methodsmentioning

confidence: 99%

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Ubeyitogullari

Ahmadzadeh

Kandhola

et al. 2022

Comp Rev Food Sci Food Safe

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Bioactive food compounds, such as lycopene, curcumin, phytosterols, and resveratrol, have received great attention due to their potential health benefits.However, these bioactive compounds (BCs) have poor chemical stability during processing and low bioavailability after consumption. Several delivery systems have been proposed for enhancing their stability and bioavailability. Among these methods, porous biopolymers have emerged as alternative encapsulation materials, as they have superior properties like high surface area, porosity, and tunable surface chemistry to entrap BCs. This reduces the crystallinity (especially for the lipophilic ones) and particle size, and in turn, increases solubilization and bioavailability. Also, loading BCs into the porous matrix can protect them against environmental stresses such as light, heat, oxygen, and pH. This review introduces polysaccharide-based porous biopolymers for improving the bioaccessibility/bioavailability of bioactive food compounds and discusses their recent applications in the food industry. First, bioaccessibility and bioavailability are described with a special emphasis on the factors affecting them. Then, porous biopolymer fabrication methods, including supercritical carbon dioxide

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Section: Porous Biopolymer Fabrication Methodsmentioning

confidence: 99%

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Ubeyitogullari

Ahmadzadeh

Kandhola

et al. 2022

Comp Rev Food Sci Food Safe

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“…A range of approaches yielding prominently biosourced single-polyelectrolyte gels have been proposed based on precipitation/coagulation through H-bonding, hydrophobic interactions, and crosslinking through reactions with either ionic or covalent crosslinkers [ 152 , 153 ]. Although this research will not be covered in this review, recently published works are highlighted for further reading on this topic [ 154 , 155 , 156 ]. In contrast, processing polyelectrolyte complexes formed from the spontaneous entropy-driven complexation of polyanions and polycations [ 34 ] into gels and membranes is a method that has only been developed recently [ 13 , 157 ].…”

Section: Gels and Vectors Based On Weak Polyelectrolytes Complexesmentioning

confidence: 99%

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

et al. 2022

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The ionization degree, charge density, and conformation of weak polyelectrolytes can be adjusted through adjusting the pH and ionic strength stimuli. Such polymers thus offer a range of reversible interactions, including electrostatic complexation, H-bonding, and hydrophobic interactions, which position weak polyelectrolytes as key nano-units for the design of dynamic systems with precise structures, compositions, and responses to stimuli. The purpose of this review article is to discuss recent examples of nanoarchitectonic systems and applications that use weak polyelectrolytes as smart components. Surface platforms (electrodeposited films, brushes), multilayers (coatings and capsules), processed polyelectrolyte complexes (gels and membranes), and pharmaceutical vectors from both synthetic or natural-type weak polyelectrolytes are discussed. Finally, the increasing significance of block copolymers with weak polyion blocks is discussed with respect to the design of nanovectors by micellization and film/membrane nanopatterning via phase separation.

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“…Aerogels are typically obtained by the supercritical (sc-)drying of gels, as this solvent extraction approach can preserve the original hydrogel nanostructure in the dry form. For this reason, the aerogel technology could help to solve the lack of nanostructuration of the as-printed structures, one of the current 3D-printing limitations [ 23 ]. Nevertheless, the production of aerogels with customized external and internal structures is still a remarkable challenge [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

3D-Printed, Dual Crosslinked and Sterile Aerogel Scaffolds for Bone Tissue Engineering

Iglesias-Mejuto

García‐González

2022

Polymers

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The fabrication of bioactive three-dimensional (3D) hydrogel scaffolds from biocompatible materials with a complex inner structure (mesoporous and macroporous) and highly interconnected porosity is crucial for bone tissue engineering (BTE). 3D-printing technology combined with aerogel processing allows the fabrication of functional nanostructured scaffolds from polysaccharides for BTE with personalized geometry, porosity and composition. However, these aerogels are usually fragile, with fast biodegradation rates in biological aqueous fluids, and they lack the sterility required for clinical practice. In this work, reinforced alginate-hydroxyapatite (HA) aerogel scaffolds for BTE applications were obtained by a dual strategy that combines extrusion-based 3D-printing and supercritical CO2 gel drying with an extra crosslinking step. Gel ageing in CaCl2 solutions and glutaraldehyde (GA) chemical crosslinking of aerogels were performed as intermediate and post-processing reinforcement strategies to achieve highly crosslinked aerogel scaffolds. Nitrogen adsorption–desorption (BET) and SEM analyses were performed to assess the textural parameters of the resulting alginate-HA aerogel scaffolds. The biological evaluation of the aerogel scaffolds was performed regarding cell viability, hemolytic activity and bioactivity for BTE. The impact of scCO2-based post-sterilization treatment on scaffold properties was also assessed. The obtained aerogels were dual porous, bio- and hemocompatible, as well as endowed with high bioactivity that is dependent on the HA content. This work is a step forward towards the optimization of the physicochemical performance of advanced biomaterials and their sterilization.

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Agarose, Alginate and Chitosan Nanostructured Aerogels for Pharmaceutical Applications: A Short Review

Cited by 39 publications

References 114 publications

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Weak Polyelectrolytes as Nanoarchitectonic Design Tools for Functional Materials: A Review of Recent Achievements

3D-Printed, Dual Crosslinked and Sterile Aerogel Scaffolds for Bone Tissue Engineering

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