Agaritine: A Natural Toxic Amino Acid Of cultivated Mushroom Agaricus Spp. And its potential Health Risk

Abstract

Agaritine, a naturally occurring amino acid and phenylhydrazine derivative found in mushrooms of the genus Agaricus, has gained attention due to its potential impact on human health. The presence of the hydrazine moiety in the structure of agaritine plays a crucial role in its toxicological properties. It has raised concerns due to its high reactivity as chemical radicals. Therefore, research is commonly focused on the potential health risks of agaritine and its possible role as a pro-carcinogenic agent. However, some studies did not provide evidence of agaritine's toxicological effects. Therefore, further research is needed to understand agaritine's mechanisms of action and its safe consumption levels in humans. This review aims to provide an overview of current knowledge surrounding agaritine and its potential health risks.