Agaricus subrufescens, a cultivated edible and medicinal mushroom, and its synonyms

Kerrigan, Richard W.

doi:10.3852/mycologia.97.1.12

Cited by 95 publications

(60 citation statements)

References 19 publications

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“…Heinemann) (25), also denoted A. subrufescens Peck (10), is a Basidiomycete that has been reported because of its antitumoral substances (2,9,16). Reports …”

Section: Agaricus Brasiliensis Wasser Et Al (A Blazei Murrill Ssmentioning

confidence: 99%

Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases

Mourão¹,

Linde²,

Messa³

et al. 2009

Braz. J. Microbiol.

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The fungus Agaricus brasiliensis is a Basidiomycete studied because of its immunomodulation and/or antitumor substances. The objective of this study was to verify the Agaricus brasiliensis antineoplasic activity in vivo on different basidiocarp maturation phases on Sarcoma 180 cells implanted in mice.Sarcoma cells were implanted in mice and after seven days mice were divided in three groups. The first group was treated with saline solution, the second group was treated with closed basidiocarp extract solution and the third group was treated with opened basidiocarp extract solution. After 30 days of being daily orally treated with these three solutions all animals suffered euthanasia, and the splenic index, tumor mass and volume were determined. No significant differences of the tumor growth inhibition in function of the different basidiocarp maturation phases for the Agaricus brasiliensis strain were observed. The in vivo basidiocarp antineoplasic average activity was 89.22%.

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“…Heinemann) (25), also denoted A. subrufescens Peck (10), is a Basidiomycete that has been reported because of its antitumoral substances (2,9,16). Reports …”

Section: Agaricus Brasiliensis Wasser Et Al (A Blazei Murrill Ssmentioning

confidence: 99%

Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases

Mourão¹,

Linde²,

Messa³

et al. 2009

Braz. J. Microbiol.

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“…In particular, the potential role of medicinal mushrooms as adjuvant therapy for solid tumors and acute leukemia has been extensively investigated [12][13][14][15]. The edible Bacidiomycota mushroom Agaricus blazei Murill (AbM) grows naturally in an area near São Paulo, Brazil, where it has been used in traditional medicine against a variety of diseases, including infection and cancer [16]. Spores of AbM were taken to Japan in the mid-60s for commercial cultivation and research.…”

Section: Introductionmentioning

confidence: 99%

Stimulation of human monocytic cells by the medicinal mushroom Agaricus blazei Murill induces expression of cell surface markers associated with activation and antigen presentation

Tangen¹,

Ama²,

Hetland³

2014

Appl Sci Rep

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Agaricus blazei Murill (AbM) is an edible Bacidiomycota phyllum mushroom used in traditional medicine as a remedy against a wide range of diseases, including infection and cancer. It is rich in β-glucans and antitumor protein-glucan complexes, which have been shown to have stimulating effects on cells involved in innate immunity, such as monocytes, NK cells and dendritic cells. The present report shows that stimulation of monocyte-derived dendritic cells (MDDC) with an AbM-based extract, AndoSan TM , induces modulation of expression of cell surface markers. Incubation of MDDC with 10% of AndoSan TM resulted in upregulation of CD1a, CD14, CD40, CD80, CD83 and CD86, de novo expression of CD69 and downregulation of CD11c expression. The modulation was time dependent. Our investigation shows the ability of AndoSan TM to immunomodulate and activate MDDC in vitro, and agrees with the recent findings of increased production of cytokines and chemokines in AndoSan TM -stimulated MDDC cultures. Furthermore, it is demonstrated that AbM can stimulate human promonocytic THP-1 cells via TLR2 and thus induce activation and migration of transcription factor NF-κB from cytosol to the nucleus. It is therefore probable that binding to TLR2 is a significant mechanism behind AndoSan TM activation of MDDC.

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“…O crescimento do micélio é inibido com pH de 3,0 ou inferior, 8,0 ou superior, ou quando CaCO 3 é utilizado para ajuste do pH para 7,0 ou superior. , also denoted Agaricus subrufescens (KERRIGAN, 2005), has been studied because of its therapeutic (MIZUNO, 2002;WATANABE et al, 2003;SOUZA-PACCOLA et al, 2004;KIMURA at al, 2004;KIM et al, 2005;SILVA et al, 2005;MANTOVANI et al, 2006) and sensory (STIJVE et al, 2002;ESCOUTO et al, 2005) properties. However, few studies describe specific techniques and parameters for A. brasiliensis cultivation, which is generally produced empirically or based on Agaricus bisporus cultivation in Brazil (BRAGA et al, 1998;BRAGA, 2003).…”

Section: Introductionmentioning

confidence: 99%

Condições de temperatura e pH para o crescimento micelial de Agaricus brasiliensis em cultivo axênico

et al. 2008

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Few studies have been done to determine Agaricus brasiliensis Wasser et al. (A. blazei; A. subrufescens) basic mycelial growth characteristics on axenic cultivation. This study aimed to determine the optimal temperature and initial pH for mycelial growth of A. brasiliensis on malt extract agar medium to develop axenic cultivation techniques. Studied initial pH values for mycelial growth were adjusted to 3.0, 4.0, 5.0, 5.5, with HCl, 6.0, 7.0, 8.0, with NaOH, and again 7.0 and 8.0, with CaCO 3 . Studied temperatures for mycelial growth were 22 ºC, 25 ºC, 28 ºC, 31 ºC and 34 ºC. It was concluded that A. brasiliensis can grow in axenic cultivation at temperature range from 22 o C to 34 ºC, with optimal temperature range from 28 o C to 31 ºC and optimal temperature value of 30.5 ºC ± 0.3 ºC. It also grows in initial pH range from 4.0 to 7.0, adjusted with HCl or NaOH but not CaCO 3 , with optimal initial pH range from 5.5 to 6.0 and optimal initial pH value of 5.56 ± 0.05. Mycelial growth is inhibited with pH of 3.0 or lower, 8.0 or higher, or when CaCO 3 is used to adjust pH in the substratum to 7.0 or higher. Key words: Growth conditions, growth inhibition, Agaricus brasiliensis, Agaricus blazei ResumoPoucos estudos foram desenvolvidos para determinar as condições básicas de crescimento micelial do fungo Agaricus brasiliensis Wasser et al. (A. blazei, A. subrufescens). O objetivo deste trabalho foi determinar a faixa ótima de temperatura e pH para o crescimento micelial, em agar-extrato-de-malte, de A. brasiliensis, visando o desenvolvimento de técnicas de cultivo axênica. Os valores de pH estudados foram 3,0, 4,0, 5,0 e 5,5, ajustados com HCl, 6,0, 7,0 e 8,0, ajustados com NaOH, e 7,0 e 8,0, ajustados com

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Agaricus subrufescens, a cultivated edible and medicinal mushroom, and its synonyms

Cited by 95 publications

References 19 publications

Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases

Antineoplasic activity of Agaricus brasiliensis basidiocarps on different maturation phases

Stimulation of human monocytic cells by the medicinal mushroom Agaricus blazei Murill induces expression of cell surface markers associated with activation and antigen presentation

Condições de temperatura e pH para o crescimento micelial de Agaricus brasiliensis em cultivo axênico

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