Agaricus blazei Murill polysaccharides/alginate/poly(vinyl alcohol) blend as dressings for wound healing

Saraiva, Matheus Morais; Campelo, Matheus da Silva; Neto, João Francisco Câmara; Gonzaga, Maria Leônia da Costa; Bastos, Maria do Socorro Rocha; Soares, Sandra de Aguiar; Ricardo, Nágila Maria Pontes Silva; Cerqueira, Gilberto Santos; Leitão, Renata Ferreira de Carvalho; Ribeiro, Maria Elenir Nobre Pinho

doi:10.1016/j.ijbiomac.2023.125278

Cited by 7 publications

(1 citation statement)

References 49 publications

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“…Agaricus blazei polysaccharide (ABP) refers to an active component extracted from ABM, primarily consisting of β-glucans [20,21]. Studies have demonstrated that ABP possesses a wide range of biological activities, including antitumor [22,23], antimicrobial [24,25], anti-inflammatory [26,27], antioxidant [28], hypoglycemic, and hypolipidemic effects [29,30]. Li Y et al [20] reported that ABP had a regulatory effect on dyslipidemia in hyperlipidemic rats, and that the mechanism may be through the modulation of high-fat diet-induced intestinal dysbiosis in rats.…”

Section: Introductionmentioning

confidence: 99%

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism

Ji,

He,

Xie

et al. 2023

Nutrients

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Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients’ quality of life. Agaricus blazei Murrill polysaccharide (ABP) is an effective active ingredient extracted from Agaricus blazei Murrill (ABM). It has good efficacy in inhibiting tumor cell growth, lowering blood pressure, and improving atherosclerosis. However, its effect on colitis is unclear. The aim of this study was to analyze the protective effects and potential mechanisms of ABP against dextran sulfate sodium (DSS)-induced acute colitis in mice. The results showed that dietary supplementation with ABP significantly alleviated DSS-induced colitis symptoms, inflammatory responses, and oxidative stress. Meanwhile, ABP intervention was able to maintain the integrity of the intestinal mechanical barrier by promoting the expression of ZO-1 and Occludin tight junction proteins and facilitating mucus secretion. Moreover, 16S rRNA sequencing results suggested that ABP intervention was able to alleviate DSS-induced gut microbiota disruption, and nontargeted metabolomics results indicated that ABP was able to remodel metabolism. In conclusion, these results demonstrate that dietary supplementation with ABP alleviated DSS-induced acute colitis by maintaining intestinal barrier integrity and remodeling metabolism. These results improve our understanding of ABP function and provide a theoretical basis for the use of dietary supplementation with ABP for the prevention of ulcerative colitis.

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