Abstract:The acidic RNA protein complex FA2bβ, isolated from Agaricus blazei Murill (AbM), has proapoptotic effects and antiproliferative potency in several cancers. In the present study, we explored whether FA2bβ can boost the sensitivity of adriamycin (ADR) to multidrug-resistant chronic myelogenous leukaemia (CML) K562/ADR cells. A bioinformatics search identified differentially expressed genes (DEGs) for enrichment analyses. The synergistic antiproliferative effect of FA2bβ and ADR was investigated using a CCK8 ass… Show more
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