Against the family veto in organ procurement: Why the wishes of the dead should prevail when the living and the deceased disagree on organ donation

Albertsen, Andreas

doi:10.1111/bioe.12661

Cited by 18 publications

(11 citation statements)

References 6 publications

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“…Interestingly, we found that the expression of P53 protein and the numbers of apoptotic cells were higher in U2OS cell line than that in Saos2 cell line following treatment with BAY 1816032 and BUB1 gene knockdown. The expression of P53 protein can induce cell apoptosis in osteosarcoma 22,23 . A previous study confirmed that the P53 protein was not present in Saos2 cells 24 but was found in U2OS cells 25 .…”

Section: Discussionmentioning

confidence: 77%

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways

Huang

Wang

Wei

et al. 2021

J Cellular Molecular Medi

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Osteosarcoma (OS) is a primary malignant bone tumour that mainly affects teenagers, with patients displaying poor prognosis. Budding uninhibited by benzimidazoles 1 (BUB1), a type of serine/threonine kinase that is linked to pro‐tumorigenic phenomena, has not been well studied in OS. Hence, this study aimed to explore the role of BUB1 in OS. The expression of BUB1 in OS specimens and cell lines was assessed using immunohistochemistry and Western blot analysis. Univariate and multivariate analyses were applied to evaluate the impact of BUB1 on patient survival. Cell counting kit‐8, wound‐healing and Transwell assays, as well as flow cytometry, were used to investigate the influence of BUB1 inhibition on OS in vitro. Moreover, a tumour xenograft model was established to investigate the in vivo effect of BUB1 inhibition on OS tumour growth. Results showed that BUB1 was overexpressed in OS specimens and cell lines. Furthermore, BUB1 overexpression was closely associated with the poor clinical outcomes of patients with OS. Inhibition of BUB1 markedly suppressed cell proliferation and tumour growth, cell migration, invasion and induced cell apoptosis of OS by blocking the PI3K/Akt and ERK signalling pathways. Thus, our study suggested that overexpression of BUB1 protein contributed to poor survival of OS patients and that inhibition of BUB1 resulted in considerable anti‐tumour activity associated with proliferation, migration, invasion and apoptosis of OS.

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Section: Discussionmentioning

confidence: 77%

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways

Huang

Wang

Wei

et al. 2021

J Cellular Molecular Medi

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“…1 The role played by the family in organ procurement decision-making may be more consequential than the model of consent (5). To help increase organ donation rates and respect individual autonomy, scholars have proposed to prevent families from overruling their loved one's intention to donate (6,7). In 2006, the USA amended the Uniform Anatomical Gift Act to restrict the family's authority to veto the deceased's first-person authorization.…”

Section: Introductionmentioning

confidence: 99%

Should the family have a role in deceased organ donation decision-making? A systematic review of public knowledge and attitudes towards organ procurement policies in Europe

Perez¹,

Delgado

Frunza

et al. 2021

Preprint

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Goal: To assess public knowledge and attitudes towards the role of the family in deceased organ donation in Europe. Methods: A systematic search was conducted in CINHAL, MEDLINE, PAIS Index, Scopus, PsycINFO, and Web of Science. These databases were last searched on December 15th, 2017. Eligibility criteria were empirical studies conducted in Europe from 2008 to 2017 and addressing either knowledge or attitudes by the public towards the consent system, including the involvement of the family in the decision-making process, for post-mortem organ retrieval. Each record was screened by two or more independent reviewers in three phases. Data collection from each report was performed by two or more independent reviewers. Results: Of the 1,482 results, 467 reports were assessed in full-text form, and 33 were included in this synthesis. Studies show that a majority of the public support the family′s involvement in organ retrieval decision-making and, in particular, their role as surrogate decision-maker when the deceased has expressed no preference. Conclusions: A common conceptual framework and validated well-designed questionnaires are needed to address the role of the family in future studies. The findings should be considered in the development of Government policy and guidance regarding the role of families in deceased organ donation.

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“…Some authors have also questioned the ethical permissibility of the family veto, but the few available studies indicate that the public support for the family veto is limited (Albertsen, 2020; Downie et al, 2008). Albertsen (2020) emphasizes that there are no arguments that could justify the family veto and disregard the deceased’s wishes. The Romanian society’s attitude toward this concept represents a new research direction that deserves to be pursued.…”

Section: Resultsmentioning

confidence: 99%

Evolution of Attitudes of a Romanian Urban Population Regarding Organ Donation

Bacuşcă¹,

Gavriluță

Grecu

et al. 2023

SAGE Open

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The rate of organ donation for transplantation as well as the utilization rate of obtained organs are still low in Romania. We performed a sociological study which aimed to identify the reasons underlying the low organ donation and transplantation rate in Romania and to analyze whether changes in the opinions of the population regarding the donation of organs for transplantation occurred in the period 2012 to 2019. We applied a panel research strategy, data collection being done by means of a questionnaire applied to the same population in two different time periods: 2012 and 2019. Our research showed that during the 7 years period the attitudes of the participants toward organ donation and transplantation have not evolved to a great extent but we observed a process of crystallization of attitudes in 2019. We also observed that a more emphasis is placed by the participants on individual autonomy in decision-making process concerning organ donation and that the highest availability for organ donation is manifested when the life of a family member is at stake. We conclude that there is a need for coherent public information policies in which the main agents would be the doctors, the school and the family.

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Against the family veto in organ procurement: Why the wishes of the dead should prevail when the living and the deceased disagree on organ donation

Cited by 18 publications

References 6 publications

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways

Inhibition of BUB1 suppresses tumorigenesis of osteosarcoma via blocking of PI3K/Akt and ERK pathways

Should the family have a role in deceased organ donation decision-making? A systematic review of public knowledge and attitudes towards organ procurement policies in Europe

Evolution of Attitudes of a Romanian Urban Population Regarding Organ Donation

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