Against all odds: The road to success in the development of human immune reconstitution mice
Yixiao Bin,
Jing Ren,
Haowei Zhang
et al.
Abstract:The mouse genome has a high degree of homology with the human genome, and its physiological, biochemical, and developmental regulation mechanisms are similar to those of humans; therefore, mice are widely used as experimental animals. However, it is undeniable that interspecies differences between humans and mice can lead to experimental errors. The differences in the immune system have become an important factor limiting current immunological research. The application of immunodeficient mice provides a possib… Show more
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