AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity

Botella-Asunción, Pablo; Rivero-Buceta, Eva M.; Vidaurre-Agut, Carla; Lama, Raquel; Rey-Campos, Magalí; Moreno, Alejandro; Mendoza, Laura; Mingo-Casas, Patricia; Escribano-Romero, Estela; Gutierrez-Adan, Alfonso; Saiz, Juan Carlos; Smerdou, Cristian; Gonzalez, Gloria; Prosper, Felipe; Argemí, Josepmaría; Miguel, Jesus San; Sanchez-Cordón, Pedro J.; Figueras, Antonio; Quesada-Gomez, Jose Manuel; Novoa, Beatriz; Montoya, María; Martín-Acebes, Miguel A.; Pineda-Lucena, Antonio; Benlloch, Jose María

doi:10.1016/j.biopha.2023.115882

Biomedicine & Pharmacotherapy

2023

DOI: 10.1016/j.biopha.2023.115882

|View full text |Cite

AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity

Pablo Botella-Asunción,

Eva M. Rivero-Buceta,

Carla Vidaurre-Agut

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Preprint1

Relationship

Self Cite1

Independent0

Authors

Journals

Cited by 1 publication

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity

Geller,

Revuelta,

Rusu

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Enveloped viruses enter cells by binding to receptors present on host cell membranes, which trigger internalization and membrane fusion. For many viruses, this either directly or indirectly involves interaction with membrane-anchored carbohydrates, such as heparan sulfate, providing a potential target for a broad-spectrum antiviral approach. Based on this hypothesis, we screened a library of functionalized chitosan sulfates that mimic heparan sulfate in cellular membranes for inhibition of SARS-CoV-2 and respiratory syncytial virus (RSV) entry. An array of compounds blocking SARS-CoV-2 and RSV were identified, with the lead compound displaying broad-spectrum activity against multiple viral strains and clinical isolates. Mechanism of action studies showed the drug to block viral entry irreversibly, likely via a virucidal mechanism. Importantly, the drug was non-toxic in vivo and showed potent post-exposure therapeutic activity against both SARS-CoV-2 and RSV. Together, these results highlight the potential of functionalized carbohydrates as broad-spectrum antivirals targeting respiratory viruses.

show abstract

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity

Geller,

Revuelta,

Rusu

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

AG5 is a potent non-steroidal anti-inflammatory and immune regulator that preserves innate immunity

Cited by 1 publication

References 53 publications

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity

Synthetic heparan sulfate mimics based on chitosan derivatives show broad-spectrum antiviral activity

Contact Info

Product

Resources

About