Ag NPs incorporated self-healable thermoresponsive hydrogel using precise structural “Interlocking” complex of polyelectrolyte BCPs: A potential new wound healing material

Banerjee, Shib Shankar; Das, Subhayan; Bhattacharya, Koushik; Kundu, Moumita; Mandal, Mahitosh; Singha, Nikhil K.

doi:10.1016/j.cej.2020.126436

Cited by 25 publications

(11 citation statements)

References 81 publications

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“…After 24 h, cytotoxicity of the treatments was determined by MTT assay following previously mentioned protocol. [47] In Vitro Live and Dead Assay: Live and the dead assay was conducted on the MDA MB 231 cell lines to confirm the cytotoxic effect of glyco@AuNPs nanoparticles. Calcein-AM dye was used for live cells, which showed green fluorescence, and propidium iodide dye for dead cells, which showed red fluorescence.…”

Section: Methodsmentioning

confidence: 99%

Gold Nanoparticle Embedded Stimuli‐Responsive Functional Glycopolymer: A Potential Material for Synergistic Chemo‐Photodynamic Therapy of Cancer Cells

Bhattacharya

Das

Kundu

et al. 2022

Macromolecular Bioscience

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Photodynamic therapy has emerged as a noninvasive treatment modality for several types of cancers. However, conventional hydrophobic photosensitizers (PS) suffer from low water solubility and poor tumor-targeting ability. Therefore, PS modified with glycopolymers can offer adequate water solubility, biocompatibility, and tumor-targeting ability due to the presence of multiple sugar units. In this study, a well-defined block copolymer poly(3-O-methacryloyl-d-glucopyranose)-b-poly(2-(4formylbenzoyloxy)ethylmethacrylate) (PMAG-b-PFBEMA) containing pendant glucose and aldehyde units is synthesized via reversible addition-fragmentation chain transfer polymerization method. A water-soluble PS (toluidine blue O; TBO) and a potent anticancer drug, Doxorubicin (Dox) are introduced to the polymer backbone via acid-labile Schiff-base reaction (PMAG-b-PFBEMA_TBO_Dox). The PMAG-b-PFBEMA_TBO_Dox is then anchored on the surface of gold nanoparticles (AuNPs) via electrostatic interaction. This hybrid system exhibits excellent reactive oxygen species (ROS) generating ability under exposure of 630 nm light-emitting diode along with triggered release of Dox under the acidic pH of tumor cells. The in vitro cytotoxicity study on human breast cancer cell line, MDA MB 231, for this hybrid system shows promising results due to the synergistic effect of ROS and Dox released. Thus, this glycopolymer-based dual (chemo-photodynamic) therapy model can work as potential material for future therapeutics.

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Section: Methodsmentioning

confidence: 99%

Gold Nanoparticle Embedded Stimuli‐Responsive Functional Glycopolymer: A Potential Material for Synergistic Chemo‐Photodynamic Therapy of Cancer Cells

Bhattacharya

Das

Kundu

et al. 2022

Macromolecular Bioscience

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“…Silver NPs find their use in a wide variety of applications such as antimicrobial agents, imaging probes, biomedical device coatings, wound healing materials, and anticancer agents depending on their size and shape. 164–167 Despite the myriad of applications of AgNPs, only a few recent literature reports are available on glycopolymer–AgNP conjugates. 146,168,169 Similar to the surface modification of AuNPs, polymer chains can be immobilized on the AgNP surface through Ag–S bond formation and catechol chemistry.…”

Section: Applicationmentioning

confidence: 99%

Tailor-made glycopolymersviareversible deactivation radical polymerization: design, properties and applications

2022

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“…These polymers self-organize with temperature variation, forming gels or hydrogels in situ [41]. Thermoresponsive spray wound dressings were produced with PNIPAM [42,43], Pluronic 127 [44], and carboxymethyl cellulose [45]. One advantage of using thermoresponsive hydrogels is the instant gelation without additives and extra steps.…”

Section: Gel and Hydrogel-based Spray Wound Dressingsmentioning

confidence: 99%

“…Among the compounds used, silver nanoparticles are the most investigated. Used in several studies, they provided the wound dressings with antimicrobial action against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa [26,27,43,56]. McLaughlin et al [74] developed a collagen I-based spray formulation containing silver nanoparticles modified with AMP LL37 to act as an antimicrobial and antibiofilm barrier with reduced side effects.…”

Section: Compounds For Infection Controlmentioning

confidence: 99%

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

Nozaki

Lima

Moraes

2022

Biomedical Materials & Devices

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The skin, as the body's main protection barrier from the environment, has an intrinsic self-repairable nature. However, proper wound healing only occurs under appropriate conditions. Skin wounds represent an economic burden on healthcare systems worldwide. Recent research has focused on developing new therapies, especially for chronic wounds. Among them, sprayapplied therapies have emerged as a promising strategy for allowing deeper penetration of the products, better conformability, easiness of application, lower discomfort for the patient, and lower risk of contamination during application. Specifically, sprayable wound dressings have been getting attention for enabling the treatment of severe cases or hard-to-heal wounds by incorporating different bioactive agents. Organic and inorganic compounds, natural extracts, signaling compounds, and live human cells have been investigated. In this context, this review summarizes the main findings of recently developed spray-applied bioactive wound dressings.

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Ag NPs incorporated self-healable thermoresponsive hydrogel using precise structural “Interlocking” complex of polyelectrolyte BCPs: A potential new wound healing material

Cited by 25 publications

References 81 publications

Gold Nanoparticle Embedded Stimuli‐Responsive Functional Glycopolymer: A Potential Material for Synergistic Chemo‐Photodynamic Therapy of Cancer Cells

Gold Nanoparticle Embedded Stimuli‐Responsive Functional Glycopolymer: A Potential Material for Synergistic Chemo‐Photodynamic Therapy of Cancer Cells

Tailor-made glycopolymersviareversible deactivation radical polymerization: design, properties and applications

Sprayable Bioactive Dressings for Skin Wounds: Recent Developments and Future Prospects

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