Ag@MIL-101(Cr) Film Substrate with High SERS Enhancement Effect and Uniformity

Abstract

Surface-enhanced Raman scattering (SERS), owing to its high sensitivity and rapid response, has been widely used in various fields. However, it is still a challenge to prepare SERS substrates with high stability and reproducibility. Metal–organic frameworks (MOFs), with excellent enrichment capacity and stability, provide a new material for high-performance SERS substrates. In this paper, we prepare a MIL-101­(Cr) film via a secondary growth method, and Ag+ is reduced to Ag NPs by UV irradiation and attach to the film to synthesize the Ag@MIL-101­(Cr) film SERS substrate. Then, we change the time of UV light illumination and the amount of silver nitrate in order to obtain the optimal substrate. The detection capability of this sample can be up to 10–11 M for 4-ATP, and the relative standard deviation (RSD) is only about 5%, which demonstrates that the substrate has excellent SERS effect and reproducibility. Finally, the prepared substrate has been applied for the determination of nitrofurantoin, with its detection capability up to 10–7 M. This work proposes a simple method to synthesize MOF-based film substrate with high SERS performance and uniformity and provides potential for the sensitive detection of chemical or antibiotic residue.

A novel SERS substrate of MIL-100(Fe)/AgNFs for sensitive detection of ascorbic acid in cellular media

“…The detection limit was 0.4 mg L −1 which is far beyond than that of MOFs or AuNPs alone. Shao 29 et al reduced Ag + to Ag on MIL-101(Cr) substrate and reached 10 −11 M for 4-ATP detection.…”

Hydrothermal Synthesis of Ag Thin Films and Their SERS Application

“…As a rule, surface-enhanced Raman spectroscopy uses substrates whose surface is modified with silver, gold, or copper nanostructures with different microstructural characteristics [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Recently, much of researchers’ attention has also been directed toward studying the processes of obtaining composite SERS-active films—Ag@nanoAu [ 4 ], Ag nanocubes@poly(dimethylsiloxane) [ 13 ], Ag/TiO 2 [ 14 ], MoO 3-x /Ag [ 15 ], b-cyclodextrin-modified Ag [ 16 ], Au/Ag and Au/Ni [ 7 , 17 ], Ag particles/Ag-Zr alloy [ 18 ], Mo-Ag [ 19 ], Ag/AgBr/ZnO [ 20 ], ZnO/Ag 3D nanocomposites [ 21 , 22 ], ZnO/Au [ 23 ], MnO 2 /Au [ 24 ], Au/ZrO 2 [ 25 ], rGO-Ag [ 26 ], or Ag/C [ 27 ].…”

A Dual-Mode NADH Biosensor Based on Gold Nanostars Decorated CoFe2 Metal–Organic Frameworks to Reveal Dynamics of Cell Metabolism

“…can act as SERS substrates to greatly enhance the Raman signals even over 10 orders of magnitude via electromagnetic enhancement, which are highly suitable for the application of SERS in biomedical applications. , For example, Masson’s group has fabricated SERS nanofibers decorated with plasmonic metal nanoparticles to monitor metabolites under different conditions. , Specifically, when the SERS nanofiber was modified with a pH-responsive molecule (4-mercaptobenzoic acid), it was able to linearly quantify intracellular pH over the range of 6.5–9.5 . Recently, it has been reported that semiconducting metal organic frameworks (MOFs) can magnify Raman signals via chemical enhancement. , Moreover, MOFs can also act as vehicles to carry individually dispersed SERS-responsive noble nanoparticles . Thus, MOF/noble nanoparticle hybrids can synergistically enhance SERS signals.…”

“…15 Recently, it has been reported that semiconducting metal organic frameworks (MOFs) can magnify Raman signals via chemical enhancement. 18,19 Moreover, MOFs can also act as vehicles to carry individually dispersed SERS-responsive noble nanoparticles. 18 attention in colorimetric detection due to their intrinsic enzyme-like property.…”

“…18,19 Moreover, MOFs can also act as vehicles to carry individually dispersed SERS-responsive noble nanoparticles. 18 attention in colorimetric detection due to their intrinsic enzyme-like property. 20 Therefore, we conceive that dualmode sensing systems based on MOF/noble nanoparticles may be designed where colorimetrics can provide convenient ensemble analysis and highly enhanced Raman signals can provide label-free and real-time detection at the cellular level.…”