Ag‐doped manganite nanoparticles: New materials for temperature‐controlled medical hyperthermia

Abstract

The purpose of this study was to introduce newly synthesized nanomaterials as an alternative to superparamagnetic ironoxide based particles (SPIO) and thus to launch a new platform for highly controllable hyperthermia cancer therapy and imaging. The new material that forms the basis for this article is lanthanum manganite particles with silver ions inserted into the perovskite lattice: La(1-x)Ag(x)MnO(3+delta). Adjusting the silver doping level, it is possible to control the Curie temperature (T(c)) in the hyperthermia range of interest (41-44 degrees C). A new class of nanoparticles based on silver-doped manganites La(1-x)Ag(x)MnO(3+delta) is suggested. New nanoparticles are stable, and their properties were not affected by the typical ambient conditions in the living tissue. It is possible to monitor the particle uptake and retention by MRI. When these particles are placed into an alternating magnetic field, their temperature increases to the definite value near T(c) and then remains constant if the magnetic field is maintained. During the hyperthermia procedure, the temperature can be restricted, thereby preventing the necrosis of normal tissue. A new class of nanoparticles based on silver-doped manganites La(1-x)Ag(x)MnO(3+delta) was suggested. Ag-doped perovskite manganites particles clearly demonstrated the effect of adjustable Curie temperature necessary for highly controllable cellular hyperthermia. The magnetic relaxation properties of the particles are comparable with that of SPIO, and so we were able to monitor the particle movement and retention by MRI. Thus, the new material combines the MRI contrast enhancement capability with targeted hyperthermia treatment.

Nanoparticle-mediated Hyperthermia in Cancer Therapy

“…For example, fluorescent quantum dots [68], silver and zinc nanoparticles and lanthanum manganite particles with impregnated silver ions [69] have been explored. However, the general principles discussed for the three nanoparticles hold true in most cases.…”

Metal, Metalloid, and Oxide Nanoparticles for Therapeutic and Diagnostic Oncology

“…Jeyaraj et al [115] have shown that biogenic Ag NPs achieved by using Sesbania grandiflora leaf extract as a novel reducing agent have a cytotoxic effect against human breast cancer (MCF-7) cell lines. Ag NPs combined with lanthanum magnetite particles are also an ideal tool for inducing hyperthermia (TC 41-44 °C) [116]. Using starch-coated silver NPs have shown an antimitotic effect on human glioblastoma cells (U2510) and human lung fibroblast cells (IMR-90).…”

Nanoscale materials for hyperthermal theranostics

“…To increase the absorption of NIR light and enhance the particle's functionality, magnetic nanocrystals can be synthesized with various coatings and ligands, such as gold 147–149 , silica 150 , carbon nanotubes 151 , polymers 94,146,152 , TiO 2 153 , Ag 148,154 , graphitic carbon 29,94 , and upconversion crystals 155–159 . The surface of magnetic particles can also be modified to be porous.…”