Ag(d), a Further Factor of the Ag-System

Bütler, R.; Brunner, E.; Scaloumbacas, N.; Politis, E.; Morganti, G.; Vierucci, A.

doi:10.1159/000465883

Cited by 2 publications

(3 citation statements)

References 3 publications

(4 reference statements)

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“…Following the finding of Beaumont [1965] that LDL can be fixed to erythrocytes by diazotization Butler and Brunner [1966] have demonstrated, using anti-Ag(x) reagent, that this method is more sensitive and, most importantly, that it led to the discovery of nonprecipitating antibodies against LDL. Using the passive hemagglutination-inhibition test, six new Ag antigens have been identified Butler and Brunner, 1968;Butler et al, 1970aButler et al, , 1970bButler et al, , 1973Butler and Brunner, 19741, of which five [Butler and Brunner 19701 are listed in the revised Ag model [Butler et al, 19741. According to this and previously proposed models for the Ag system, a total of ten different Ag factors exist [Ag(al), Ag(c), Ag(d), Ag(g), Ag(h), Ag(i), Ag(t), Ag(x), Ag(y), and Ag(z)] determined by five pairs of allelic genes (Aga@, Agc.9, AghJi, AgtJ and A g W ) -the fate of the 1 l t h Ag factor, Ag(m) [Contu, 19681, is unknown. The similarities between this system and other lipoprotein systems in other animals such as Lpq in rabbit, Lmp in rhesus monkeys, and Lpp in swine, will be discussed later.…”

Section: Manmentioning

confidence: 99%

Lipoprotein immunogenetics and atherosclerosis

Rapacz

Opitz²

1978

Am. J. Med. Genet.

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The discovery of the first human lipoprotein polymorphism by Allison and Blumberg [Lancet i:634-637, 1961] and the availability of alloimmune sera stimulated us to begin immunogenetic studies on swine in search of lipoprotein diversity and its relationship to biological functions. We found considerable lipoprotein polymorphism, complexity, and heterogeneity in this species. These results and the correlation between immunogenetically defined lipoprotein type and arterial lipidosis in swine, fed a high fat diet, are discussed. Immunogenetic studies of lipoproteins, initiated more recently in rhesus monkeys, will be reviewed also. Preliminary data show similarities between these two species with regard to polymorphism, complexity, phenotypic expression of lipoprotein genes and, most importantly, their serological relationship to human lipoproteins. We also note immunogenetic studies on lipoproteins done by other investigators, or in other species. Brief remarks on implications of the lipoproteins in atherosclerosis, their general classification, immunological properties, and immunological methods used in their study precede the immunogenetic presentation.

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Section: Manmentioning

confidence: 99%

Lipoprotein immunogenetics and atherosclerosis

Rapacz

Opitz²

1978

Am. J. Med. Genet.

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“…

In the past we have detected a number of hereditary factors in human serum, which we attributed to serum low density lipoprotein (LDL) [1,4,7,8,9]. They were detected mainly by means of a passive hemagglutination/inhibition method [3,10], Whereas three of these factors (Ag(c), Ag(d) and Ag(g)) were shown to belong to the Ag(a1,t,x,y,z)-system of serum LDL [5,7,9], a fourth factor which we tentatively called 'Ag(e)' appeared to be genetically independent from the Ag-system [5].

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mentioning

confidence: 99%

“…They were detected mainly by means of a passive hemagglutination/inhibition method [3,10], Whereas three of these factors (Ag(c), Ag(d) and Ag(g)) were shown to belong to the Ag(a1,t,x,y,z)-system of serum LDL [5,7,9], a fourth factor which we tentatively called 'Ag(e)' appeared to be genetically independent from the Ag-system [5]. We have recently observed that the 'Ag(e)'-antigen, which occurs in 55.8% of the Caucasian population [5], exhibits a marked thermostability [2].…”

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confidence: 99%