Aftermath of the Human Genome Project: an era of struggle and discovery

Hamdoun, Zainab; Ehsan, Hashimul

doi:10.3906/biy-1609-77

Cited by 3 publications

(2 citation statements)

References 85 publications

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“…, ; Ricke et al . , ; Hamdoun and Ehsan ). Much of this was driven by the development of multiple sequencing hardware advancements, which have led to bench top models more amenable for smaller research laboratories (Quail et al .…”

Section: Salmonella Identification and Epidemiology—wgsmentioning

confidence: 97%

Molecular‐based identification and detection ofSalmonellain food production systems: current perspectives

et al. 2018

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Salmonella remains a prominent cause of foodborne illnesses and can originate from a wide range of food products. Given the continued presence of pathogenic Salmonella in food production systems, there is a consistent need to improve identification and detection methods that can identify this pathogen at all stages in food systems. Methods for subtyping have evolved over the years, and the introduction of whole genome sequencing and advancements in PCR technologies have greatly improved the resolution for differentiating strains within a particular serovar. This, in turn, has led to the continued improvement in Salmonella detection technologies for utilization in food production systems. In this review, the focus will be on recent advancements in these technologies, as well as potential issues associated with the application of these tools in food production. In addition, the recent and emerging research developments on Salmonella detection and identification methodologies and their potential application in food production systems will be discussed.

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Section: Salmonella Identification and Epidemiology—wgsmentioning

confidence: 97%

Molecular‐based identification and detection ofSalmonellain food production systems: current perspectives

et al. 2018

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“…Particularly, it is the genome of our own species. 6 Data obtained from sequencing the human genome revealed that it is characterized by a number of remarkable features 25 : (1) the human genome is composed of 3 billion pairs of nucleotide bases 26 ; (2) all human beings share 99.9% similarity at the DNA level, only 0.1% of genetic variation exist 27 ; (3) the most common genetic variations are single-nucleotide polymorphisms (SNPs). 27 There are about 10 million SNPs in the human genome.…”

Section: Revelations From the Hgpmentioning

confidence: 99%

Genomic Interventions in Medicine

Aworunse

Adeniji

Oyesola

et al. 2018

Bioinform Biol Insights

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Lately, the term “genomics” has become ubiquitous in many scientific articles. It is a rapidly growing aspect of the biomedical sciences that studies the genome. The human genome contains a torrent of information that gives clues about human origin, evolution, biological function, and diseases. In a bid to demystify the workings of the genome, the Human Genome Project (HGP) was initiated in 1990, with the chief goal of sequencing the approximately 3 billion nucleotide base pairs of the human DNA. Since its completion in 2003, the HGP has opened new avenues for the application of genomics in clinical practice. This review attempts to overview some milestone discoveries that paved way for the initiation of the HGP, remarkable revelations from the HGP, and how genomics is influencing a paradigm shift in routine clinical practice. It further highlights the challenges facing the implementation of genomic medicine, particularly in Africa. Possible solutions are also discussed.

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