African walnuts attenuate ectopic fat accumulation and associated peroxidation and oxidative stress in monosodium glutamate-obese Wistar rats

Uti, Daniel Ejim; Atangwho, Item Justin; Eyong, Eyong Ubana; Umoru, Grace Ufedo; Egbung, Godwin Eneji; Nna, Victor Udo; Udeozor, Precious A.

doi:10.1016/j.biopha.2020.109879

Cited by 11 publications

(5 citation statements)

References 21 publications

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“…A previous study demonstrated that a combination of Coleus forskohlii root extract, citrus fruit extract, dihydrocapsiate, and red pepper fruit extract contributed to reducing body weight and fat gain under a high-fat diet [ 52 ]. Other studies in respect of traditional African medicine showed a weight-loss effect of African walnuts in Wistar rats [ 53 ] and an in vitro study of Gnidia glauca [ 54 ] and Vernonia mespilifolia Less. demonstrated anti-obesity and antioxidant effects [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals

et al. 2022

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We investigated the effects of Irvingia gabonensis (IG) kernel extract on the metabolism, adiposity indices, redox status, inflammation, adipocytokines, blood leukocyte relative telomere length (RTL), and aerobic capacity of overweight/obese individuals. All participants used the first 12-week phase to monitor body weight. They were then randomly divided into two groups: (1) 300 mg IG or (2) placebo (PLA). Both groups took one tablet per day for 12 weeks. The variables were measured before supplementation and after 3, 6, and 12 weeks of supplementation. RTL and aerobic capacity were measured before and after 12 weeks. Compared with the PLA, the IG increased plasma vitamin C after supplementation at 6 (p < 0.01) and 12 weeks (p < 0.05) and serum adiponectin after 3 weeks (p < 0.05). Compared with before supplementation, plasma malondialdehyde and serum leptin were decreased after 12-week supplementation in both groups and in the PLA, respectively, without any differences between the groups. There were no differences between groups with respect to metabolism, inflammation, RTL, and aerobic capacity after the supplementation. We suggest that 12-week daily IG supplementation improved plasma vitamin C and adiponectin. The findings show the possible mechanism contributing to the effect of IG supplementation on a reduction in obesity-related complications.

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Section: Discussionmentioning

confidence: 99%

Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals

et al. 2022

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“…It is important to investigate the paternal implications of the onset of obesity and other metabolic disorders in offspring. MSG has shown toxic effects on several systems ( 11 , 37 ), and offspring from MSG-induced obese rats can be used as a model for obesity studies since it impacts on offspring metabolism and body weight and can be compared to other models ( 6 , 37 ).…”

Section: Discussionmentioning

confidence: 99%

“…Experimental models might contribute towards understanding the pathophysiological mechanisms and consequences concerning transgenerational obesity ( 6 , 9 ). When administered to neonatal rats, monosodium glutamate (MSG) is recognized to cause obesity and clinical manifestations of metabolic syndrome ( 6 , 11 ). MSG provokes hypothalamic lesions resulting in several endocrine disturbances, stunted growth, and obesity ( 7 , 12 ).…”

Section: Introductionmentioning

confidence: 99%

Paternal obesity and its transgenerational effects on gastrointestinal function in male rat offspring

Machado

Gama

Beckmann

et al. 2021

Braz J Med Biol Res

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The interplay between obesity and gastrointestinal (GI) motility is contradictory, and the transgenerational influence on this parameter is unknown. We aimed to evaluate the GI function in a model of paternal obesity and two subsequent generations of their male offspring. Newborn male rats were treated with monosodium glutamate (MSG) and composed the F1 generation, while control rats (CONT) received saline. At 90 days, male F1 were mated with non-obese females to obtain male offspring (F2), which later mated with non-obese females for obtaining male offspring of F3 generation. Lee Index analysis was adopted to set up the obesity groups. Alternating current biosusceptometry (ACB) technique was employed to calculate GI transit parameters: mean gastric emptying time (MGET), mean cecum arrival time (MCAT), mean small intestinal transit time (MSITT), and gastric frequency and amplitude of contractions. Glucose, insulin, and leptin levels and duodenal morphometry were measured. F1 obese rats showed a decrease in the frequency and amplitude of gastric contractions, while obese rats from the F2 generation showed accelerated MGET and delayed MCAT and MSITT. Glucose and leptin levels were increased in F1 and F2 generations. Insulin levels decreased in F1, F2, and F3 generations. Duodenal morphometry was altered in all three generations. Obesity may have paternal transgenerational transmission, and it provoked disturbances in the gastrointestinal function of three generations.

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“…In addition, other substances with antioxidant activity can also improve the function of adipose tissue. For example, walnut extract can relieve extrahepatic lipid generation, improve the level of reduced glutathione, increase the activities of GSH-Px and SOD, and reduce the accumulation of ectopic fat and its related oxidative stress state in rats [ 123 ]. Grape extract can prevent dyslipidemia by regulating lipase activity, increasing antioxidant capacity, and reducing transition metals and free radicals, such as O 2 − and OH [ 124 ].…”

Section: The Impact Of Nutritional Interventionsmentioning

confidence: 99%

Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions

Wang

2022

Nutrients

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Adipose tissue is the largest and most active endocrine organ, involved in regulating energy balance, glucose and lipid homeostasis and immune function. Adipose tissue aging processes are associated with brown adipose tissue whitening, white adipose tissue redistribution and ectopic deposition, resulting in an increase in age-related inflammatory factors, which then trigger a variety of metabolic syndromes, including diabetes and hyperlipidemia. Metabolic syndrome, in turn, is associated with increased inflammatory factors, all-cause mortality and cognitive impairment. There is a growing interest in the role of nutritional interventions in adipose tissue aging. Nowadays, research has confirmed that nutritional interventions, involving caloric restriction and the use of vitamins, resveratrol and other active substances, are effective in managing adipose tissue aging’s adverse effects, such as obesity. In this review we summarized age-related physiological characteristics of adipose tissue, and focused on what nutritional interventions can do in improving the retrogradation and how they do this.

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African walnuts attenuate ectopic fat accumulation and associated peroxidation and oxidative stress in monosodium glutamate-obese Wistar rats

Cited by 11 publications

References 21 publications

Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals

Effects of Irvingia gabonensis Extract on Metabolism, Antioxidants, Adipocytokines, Telomere Length, and Aerobic Capacity in Overweight/Obese Individuals

Paternal obesity and its transgenerational effects on gastrointestinal function in male rat offspring

Adipose Tissue Aging and Metabolic Disorder, and the Impact of Nutritional Interventions

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