The work considered comparative analysis of CRI (Curcuma longa rhizome extract indicator) and TLI (Tectona grandis leaves extract indicator) as green indicators versus some synthetic indicators in acid -base titration involving HCl-NaOH, CH3COOH-NaOH, CH3COOH -NH4OH, and HCl-NH4OH. The codes used were SA (strong acid), SB (strong base), WA (weak acid) and WB (weak base). 10 mL of the base with three drops of the CRI, TLI, MO (methyl orange), and PL (phenolphthalein) were used. Prior to the titrations, the extracts of Curcuma longa rhizome and Tectona grandis leaves were tested for their colours in acidic and basic media. Also, the UV-visible absorptions of the extracts were determined. There were sharp colours of yellow (for CRI) and red (for TLI) in acid and brown (for CRI) and black (for TLI) in base media. Meanwhile, CRI absorbed (absorbance of 0.83-0.85) substantially at 400-450 nm, but gave lesser absorption at 500-800 nm with absorbance of 0.55-0.24. On the other hand, TLI was found with higher absorbance (0.09) at 400 nm and lesser absorption (absorbance ~0.04) at 720 nm. The titre values of 10.95±0.95 mL (SA-SB), 13.75±0.15 mL (WA-SB), 2.15±0.15 mL (WA-WB), 1.85±0.05 mL (SA-WB) and 11.70±0.3 mL (SA-SB), 13.45±0.45 mL (WA-SB), 2.15±0.05 mL (WA-WB), 2.20±0 mL (SA-WB) were obtained for CRI and TLI, respectively. The results matched with the values 12.25±0.15 mL (SA-SB), 13.90±0.7 mL (WA-SB), 2.10±0.2 mL (WA-WB), and 3.00±0.6 mL (SA-WB) of PL and MO, respectively. It will be beneficial to us to replace the use of MO and PL as indicators with CRI and TLI, because these green indicators are more benign and also effective. This will facilitate the eradication of toxicity accruing from synthetic indicators, MO and PL. In the future, we are looking out to determining the pKa and stability of these natural indicators.