African Immigrants in New York City with Hepatitis B-Related Hepatocellular Carcinoma Demonstrate High Morbidity and Mortality

Carr, John Alfred; Eun, Da; Shaltiel, Tali; Zheng, Serena; Siderides, Cleo; Golas, Benjamin; Labow, Daniel M.; Magge, Deepa; Cohen, Noah; Branch, Andrea D.; Sarpel, Umut

doi:10.1007/s10903-021-01205-8

Cited by 1 publication

(2 citation statements)

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“…In a retrospective cohort study of 4400 patients with HCC, of whom 33 were identified as African immigrants, 64% presented with late-stage, inoperable HCC and 77% died within 1 year of HCC diagnosis. [102] Over 70% of patients were unaware of their HBV diagnosis when they presented with HCC, and zero patients were diagnosed through a screening exam. The early age at onset of HCC among African persons with CHB was also recently demonstrated in a large, multicenter retrospective study from the Africa Liver Cancer Consortium in which 59% of HBV-associated HCCs developed before the age of 40 years.…”

Section: Discussionmentioning

confidence: 99%

“…While this study did not distinguish between Black Americans and African immigrants, recent data suggest that African immigrants with CHB may have even worse outcomes. In a retrospective cohort study of 4400 patients with HCC, of whom 33 were identified as African immigrants, 64% presented with late‐stage, inoperable HCC and 77% died within 1 year of HCC diagnosis 102. Over 70% of patients were unaware of their HBV diagnosis when they presented with HCC, and zero patients were diagnosed through a screening exam.…”

Section: Discussionmentioning

confidence: 99%

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Health disparities in chronic liver disease

et al. 2022

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The syndemic of hazardous alcohol consumption, opioid use, and obesity has led to important changes in liver disease epidemiology that have exacerbated health disparities. Health disparities occur when plausibly avoidable health differences are experienced by socially disadvantaged populations. Highlighting health disparities, their sources, and consequences in chronic liver disease is fundamental to improving liver health outcomes.There have been large increases in alcohol use disorder in women, racial and ethnic minorities, and those experiencing poverty in the context of poor access to alcohol treatment, leading to increasing rates of alcoholassociated liver diseases. Rising rates of NAFLD and associated fibrosis have been observed in Hispanic persons, women aged > 50, and individuals experiencing food insecurity. Access to viral hepatitis screening and linkage to treatment are suboptimal for racial and ethnic minorities and individuals who are uninsured or underinsured, resulting in greater liver-related mortality and later-stage diagnoses of HCC. Data from more diverse cohorts on autoimmune and cholestatic liver diseases are lacking, supporting the need to study the contemporary epidemiology of these disorders in greater detail.Herein, we review the existing literature on racial and ethnic, gender, and socioeconomic disparities in chronic liver diseases using a social determinants of health framework to better understand how social and structural factors cause health disparities and affect chronic liver disease outcomes. We also propose potential solutions to eliminate disparities, outlining healthpolicy, health-system, community, and individual solutions to promote equity and improve health outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%