African histoplasmosis: osteomyelitis of the radius

Onwuasoigwe, Okechukwu; Gugnani, H. C.

doi:10.1111/j.1439-0507.1998.tb00309.x

Cited by 15 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 Complications such as rupture of muscles and tendons, 7 hematoma with secondary infection, 8 hypercalcemia, 4 and multiple osseous lesions corresponding to progressive disseminated histoplasmosis 9 were found in 4 (26.7%) different patients. Overall, 11 (73.3%) patients recovered, 2-4,6-8,12-16 2 (13.3%) were progressing well with treatment, 8,9 1 (6.7%) patient died, 10 and 1 (6.7%) was lost to follow-up. 11…”

Section: Resultsmentioning

confidence: 99%

“…All patients were diagnosed through a positive culture of the tissue to Histoplasma spp. Eight (53.3%) patients were diagnosed with tenosynovitis, 2-4,7-9,11,12 5 (33.3%) with osteomyelitis, 6,10,13-15 1 (6.7%) with carpal tunnel syndrome, 16 and 1 (6.7%) with joint wrist abscess 8 caused by histoplasmosis. Regarding surgical treatment, of the patients diagnosed with tenosynovitis, 5 underwent tenosynovectomy, 2,7-9,12 2 only had a biopsy of the lesion, 3,11 and 1 had an exploration with carpal tunnel release and biopsy.…”

Section: Resultsmentioning

confidence: 99%

“…4 Of the patients diagnosed with osteomyelitis, 2 underwent biopsy alone 10,14 and 3 had debridement of the affected area. 6,13,15 The patient with carpal tunnel syndrome had a release of the transverse carpal ligament, tenosynovectomy, and transverse carpal ligament repair, 16 and the patient with articular abscess underwent a surgical exploration with drainage of the wrist. 8 Of the total number of cases, 7 (46.7%) patients were initially mistreated with anti-inflammatory medication or analgesic pain relievers.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, histoplasmosis classically presents in immunocompromised patients 2,3,7-10 ; however, there were immunocompetent patients who also developed the disease. 4,6,11-16 Diagnosis and management of the disease remain a challenge due to its infrequent occurrence in the upper extremities, which may explain the lack of a specific protocol to follow in such cases. Below, we describe a point-by-point surgical and medical treatment approach for histoplasmosis affecting the upper extremities, causing tenosynovitis, osteomyelitis, carpal tunnel syndrome, and abscess in the wrist.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Histoplasmosis of the Upper Extremities: Clinical Case, Treatment Algorithm, and Systematic Review

Huayllani

Restrepo

Boczar

et al. 2020

Hand (New York, N,Y.)

View full text Add to dashboard Cite

Background: Histoplasmosis of the upper extremities is extremely rare, and there is no consensus in its management. The aim of this study was to present a case report and literature review of histoplasmosis in the upper extremities to provide the best treatment recommendation and to increase awareness of this disease. Methods: A systematic review of the literature was performed in PubMed, MEDLINE, and EMBASE databases with the search terms “(Tenosynovitis AND histoplasmosis)” OR “(Upper limbs AND histoplasmosis)” OR “(Upper extremities AND histoplasmosis)” OR “((finger OR arm OR hand OR forearm OR wrist) AND histoplasmosis).” Manuscripts were included in the study if they described diagnosis of histoplasmosis in the bone, joint, synovia, or tendons of the upper extremities. Results: In all, 14 manuscripts and 15 cases of histoplasmosis of the upper extremities from 1992 to 2015 met the inclusion criteria. Eight (53.3%) patients were diagnosed with tenosynovitis, 5 (33.3%) with osteomyelitis, 1 (6.7%) with carpal tunnel syndrome, and 1 (6.7%) with joint wrist abscess. Immunosuppression, travel history, previous diagnosis with histoplasmosis, and persistent symptoms may suggest infectious causes. Surgery and medical treatment together are recommended to optimize outcomes compared with single treatment alone. Conclusions: Histoplasmosis of the upper extremities may have various clinical presentations, including tenosynovitis, osteomyelitis, carpal tunnel syndrome, and joint wrist abscess. The type of surgical approach may depend on the etiology of disease. Increased awareness and knowledge of the clinical signs, symptoms, and effective treatment modalities will help decrease possible complications, such as tendon rupture and functional impairment of the upper extremities.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Histoplasmosis of the Upper Extremities: Clinical Case, Treatment Algorithm, and Systematic Review

Huayllani

Restrepo

Boczar

et al. 2020

Hand (New York, N,Y.)

View full text Add to dashboard Cite

show abstract

“…We reviewed 18 published cases of H. capsulatum var. duboisii bone infections [10][11][12][13][14][15][16][17][18]. All patients came from West Africa, the median age was 28 years (range, 2-65 years), and 9 were female.…”

mentioning

confidence: 99%

A 53-Year-Old Woman With an Unusual Etiology of Joint Pain

Moulin

Hauser

Rey³

et al. 2015

Clinical Infectious Diseases

View full text Add to dashboard Cite

Fungal Infections

Haque

McGinnis

2008

Dail and Hammar’s Pulmonary Pathology

View full text Add to dashboard Cite

The incidence of invasive fungal infections has increased dramatically over the past two decades, mostly due to an increase in the number of immunocompromised patients. l -4 Patients who undergo chemotherapy for a variety of diseases, patients with organ transplants, and patients with the acquired immune deficiency syndrome have contributed most to the increase in fungal infections. s The actual incidence of invasive fungal infections in transplant patients ranges from 15% to 25% in bone marrow transplant recipients to 5% to 42% in solid organ transplant recipients. 6 ,7 The most frequently encountered are Aspergillus species, followed by Cryptococcus and Candida species. Fungal infections are also associated with a higher mortality than either bacterial or viral infections in these patient popUlations. This is because of the limited number of available therapies, dose-limiting toxicities of the antifungal drugs, fewer symptoms due to lack of inflammatory response, and the lack of sensitive tests to aid in the diagnosis of invasive fungal infections. I A study of patients with fungal infections admitted to a university-affiliated hospital indicated that communityacquired infections are becoming a serious problem; 67% of the 140 patients had community-acquired fungal pneumonia. 8 There is also an increase in nosocomial fungal infections.9Fungi are eukaryotic, unicellular to multicellular organisms that have chitinous cell walls, and reproduce asexually, sexually, or both ways. Fungal cells are larger and genomically more complex than bacteria. Their cell wall contains polysaccharides, proteins, and sugars, and their antigens are rich in complex polysaccharides and glycoproteins. Plasma membranes of fungi contain ergosterol, which is the primary target for antifungals such as amphotericin B. Although there are more than 1.3 million fungal species in the environment, only about 150 are known to be pathogenic to humans. For detailed taxonomy of the fungi, several texts are available. W-12 The virulence factors of fungi resemble those of bacteria, such as possession of a capsule, adhesion molecules, toxins, free radicals, etc.

show abstract

African histoplasmosis: osteomyelitis of the radius

Cited by 15 publications

References 4 publications

Histoplasmosis of the Upper Extremities: Clinical Case, Treatment Algorithm, and Systematic Review

Histoplasmosis of the Upper Extremities: Clinical Case, Treatment Algorithm, and Systematic Review

A 53-Year-Old Woman With an Unusual Etiology of Joint Pain

Fungal Infections

Contact Info

Product

Resources

About