African Americans’ participation in clinical research: importance, barriers, and solutions

Branson, Richard D.; Davis, Kenneth G.; Butler, Karyn L.

doi:10.1016/j.amjsurg.2005.11.007

Cited by 151 publications

(128 citation statements)

References 24 publications

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“…Moreover, it might also suggest an underrepresentation of African-American individuals in research studies. [24][25][26] In a pooled analysis of 869 elderly NDMM patients participating in clinical trials, a geriatric assessment to risk-stratify Connect MM Registry and Baseline Disease Characteristics patients has been proposed. 12 Variables include patient age, Charlson Comorbidity Index scores, activities of daily living (ADL) scores, and instrumental ADL scores to categorize patients as fit, unfit, and frail.…”

Section: Discussionmentioning

confidence: 99%

Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics

Rifkin

Abonour

Terebelo

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

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Section: Discussionmentioning

confidence: 99%

Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics

Rifkin

Abonour

Terebelo

et al. 2015

Clinical Lymphoma Myeloma and Leukemia

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“…The barriers to CT participation have been studied extensively, with these barriers primarily falling into two categories: patient-and physician-related barriers. Patient-related barriers include cognitive barriers, such as lack of awareness or understanding about CTs [13], structural barriers, which include concerns about participation costs, travel and insurance coverage [14], and psychological barriers, including misperceptions, distrust, and fear [15]. Physician-related barriers include limited knowledge of ongoing CTs, unsupportive attitudes, and a lack of motivation to enroll patients [16,17].…”

mentioning

confidence: 98%

Promoting clinical research to medically underserved communities: Current practices and perceptions about clinical trial recruiting strategies

Tanner

Kim

Friedman

et al. 2015

Contemporary Clinical Trials

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“…Finally, specific healthcare systems may present obstacles that delay uninsured patients from gaining timely management. 63 Further investigation of healthcare access for Black women with gynecologic problems is necessary to identify potential barriers that prevent patients from being diagnosed with less advanced cancers. Alternatively, Black women may present with more advanced tumors that reflect tumors that have biologic alterations associated with more aggressive behavior when compared with gynecologic cancers from White women.…”

Section: Resultsmentioning

confidence: 99%

Racial disparities in blacks with gynecologic cancers

Farley

Risinger

Rose

et al. 2007

Cancer

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Black women have a lower incidence of gynecologic cancers but they have a higher mortality associated with their disease. The etiology of the racial disparity in outcome among gynecologic cancer patients is multifactoral and site-specific.Black women with endometrial cancer often present with more advanced stage tumors that are associated with a worse prognosis compared with White women.Evidence suggests that observed disparities in outcome are due to inequalities in treatment or differing biologic etiologies. For cervix cancer, studies have suggested that survival among Black women may be lower than survival among White women that develop this disease. This occurs despite evidence that indicates that Pap smears are utilized similarly by Black and White women for cervix cancer screening. These differences in outcome may become less pronounced when comorbidities are accounted for and inequalities in treatment are eliminated. For ovarian cancer patients, survival has improved with the use of contemporary therapies over the past 30 years in Whites but less so for Blacks. This may be due to differences in the likelihood of primary surgical cytoreductions, which are performed less frequently in some Black women because of extensive metastatic spread or comorbidities. The observed decreases in survival for all 3 gynecologic cancers potentially may be affected by socioeconomic status of the patient in some healthcare settings. An improved understanding of the causative factors associated with racial disparities in gynecologic cancer outcome is necessary to facilitate efforts aimed at correcting this important healthcare problem.

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African Americans’ participation in clinical research: importance, barriers, and solutions

Cited by 151 publications

References 24 publications

Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics

Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics

Promoting clinical research to medically underserved communities: Current practices and perceptions about clinical trial recruiting strategies

Racial disparities in blacks with gynecologic cancers

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