Summary An evolution of thought and practice regarding the relationship of racism to well-being, healing, and trauma continues within social work and the helping professions. Additionally, empirical research on colorism as a key dimension of racism suggests that colorism negatively impacts the psychological and physical well-being of African Americans. However, few studies have examined well-being among African Americans in the context of historical trauma, through the lens of colorism. In this paper, the intersectionality of colorism and historical trauma is explored to inform culturally responsive social work education, practice, and research regarding African American well-being. It is the first step toward developing a colorist-historical trauma framework. The impact of colorism as a function of historical trauma response transmission among African Americans is presented. Findings Advances in culturally responsive practice in social work address the impact of social determinants of health, such as racism. However, the impact of colorism within systemic racism is often unacknowledged. The authors assert that social work practice must attune to the differentiated socioemotional, political, and economic needs that exist among African Americans due to the impact of colorism and historical trauma. An intersectional lens, such as the colorist-historical trauma framework, is essential for culturally responsive practice. Applications The colorist-historical trauma framework contributes to the professional social work discourse aimed at strengthening effective micro-, meso-, and macro-level practice with African Americans for well-being. Implications for social work practice, research, and education are presented.