In order to study the rheological properties of warm mix asphalt modified by desulfurized rubber powder with different meshes, the desulfurized rubber powder was mixed with matrix asphalt at the best content. Dynamic shear rheological test (DSR) was used to study the high temperature rheological properties of asphalt modified by waste rubber powder. Multi-stress creep test (MSCR) was used to study the high temperature deformation resistance of asphalt modified with waste rubber powder. The low temperature rheological properties of Sasobit and crumb rubber modified asphalt with different mesh numbers were evaluated by bending beam rheological test (BBR). The test results show that compared with the base asphalt, the complex modulus and rutting factor of CRMA 60 are significantly improved, and the effect is more obvious than that of CRMA 40 and CRMA 80. With the addition of Sasobit, the high temperature performance of WCRMA first increased and then decreased. With the addition of Sasobit, the creep stiffness modulus of WCRMA decreases, the creep rate increases, and the low-temperature properties first increase and then decrease. From the atomic force microscope (AFM), it can be seen that Sasobit promotes the compatibility between rubber powder and asphalt, and the performance of asphalt modified by 60 mesh rubber powder is best. When the mass fraction of Sasobit is 2.5%, WCRMA has the best comprehensive performance.