Aflatoxin degradation by Bacillus subtilis UTB1 is based on production of an oxidoreductase involved in bacilysin biosynthesis

Afsharmanesh, Hamideh; Pérez-Garcı́a, Alejandro; Zeriouh, Houda; Ahmadzadeh, Masoud; Romero, Diego

doi:10.1016/j.foodcont.2018.03.002

Cited by 46 publications

(18 citation statements)

References 36 publications

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“…B. subtilis can secrete a variety of low molecular weight antimicrobial peptides and bacteriocins, such as surfactin [ 81 ], bacilysin [ 82 ], and subtilin [ 83 ], which have potential value in biomedical engineering, food and agriculture [ 84 ]. Antimicrobial peptides from B. subtilis are promising therapeutic tools, because of their broad activity and rapid killing activity against a variety of pathogens.…”

Section: Application Of Bacillus Subtilis In Amentioning

confidence: 99%

Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Chuan²,

Fang³

et al. 2020

Microb Cell Fact

227

118

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Due to its clear inherited backgrounds as well as simple and diverse genetic manipulation systems, Bacillus subtilis is the key Gram-positive model bacterium for studies on physiology and metabolism. Furthermore, due to its highly efficient protein secretion system and adaptable metabolism, it has been widely used as a cell factory for microbial production of chemicals, enzymes, and antimicrobial materials for industry, agriculture, and medicine. In this mini-review, we first summarize the basic genetic manipulation tools and expression systems for this bacterium, including traditional methods and novel engineering systems. Secondly, we briefly introduce its applications in the production of chemicals and enzymes, and summarize its advantages, mainly focusing on some noteworthy products and recent progress in the engineering of B. subtilis . Finally, this review also covers applications such as microbial additives and antimicrobials, as well as biofilm systems and spore formation. We hope to provide an overview for novice researchers in this area, offering them a better understanding of B. subtilis and its applications.

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Section: Application Of Bacillus Subtilis In Amentioning

confidence: 99%

Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Chuan²,

Fang³

et al. 2020

Microb Cell Fact

227

118

View full text Add to dashboard Cite

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“…Oxidoreductase BacC from Bacillus subtilis also assumed by authors [75] to break a lactone ring of aflatoxin B 1 . However, according to its native activity in bacilysin synthesis [76], this enzyme should rather form an epoxy cycle at the same double bond as aforementioned cytochromes.…”

Section: Aflatoxinsmentioning

confidence: 99%

Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action

2019

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Mycotoxins are highly dangerous natural compounds produced by various fungi. Enzymatic transformation seems to be the most promising method for detoxification of mycotoxins. This review summarizes current information on enzymes of different classes to convert various mycotoxins. An in-depth analysis of 11 key enzyme mechanisms towards dozens of major mycotoxins was realized. Additionally, molecular docking of mycotoxins to enzymes’ active centers was carried out to clarify some of these catalytic mechanisms. Analyzing protein homologues from various organisms (plants, animals, fungi, and bacteria), the prevalence and availability of natural sources of active biocatalysts with a high practical potential is discussed. The importance of multifunctional enzyme combinations for detoxification of mycotoxins is posed.

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“…Aflatoxin degradation in laboratory conditions has been investigated in numerous cases over the years [107,108,109,110], but there is currently no biological system for the entire commercial sphere to be used. Interesting results have been obtained for Nocardia corynebacteroides application.…”

Section: Biological Detoxification and Biotransformationmentioning

confidence: 99%

Decontamination of Mycotoxin-Contaminated Feedstuffs and Compound Feed

Čolović

Puvača

Cheli

et al. 2019

Toxins

132

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Mycotoxins are known worldwide as fungus-produced toxins that adulterate a wide heterogeneity of raw feed ingredients and final products. Consumption of mycotoxins-contaminated feed causes a plethora of harmful responses from acute toxicity to many persistent health disorders with lethal outcomes; such as mycotoxicosis when ingested by animals. Therefore, the main task for feed producers is to minimize the concentration of mycotoxin by applying different strategies aimed at minimizing the risk of mycotoxin effects on animals and human health. Once mycotoxins enter the production chain it is hard to eliminate or inactivate them. This paper examines the most recent findings on different processes and strategies for the reduction of toxicity of mycotoxins in animals. The review gives detailed information about the decontamination approaches to mitigate mycotoxin contamination of feedstuffs and compound feed, which could be implemented in practice.

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Aflatoxin degradation by Bacillus subtilis UTB1 is based on production of an oxidoreductase involved in bacilysin biosynthesis

Cited by 46 publications

References 36 publications

Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Bacillus subtilis: a universal cell factory for industry, agriculture, biomaterials and medicine

Enzymes for Detoxification of Various Mycotoxins: Origins and Mechanisms of Catalytic Action

Decontamination of Mycotoxin-Contaminated Feedstuffs and Compound Feed

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