Aflatoxin and hepatitis B virus biomarkers: A paradigm for complex environmental exposures and cancer risk

Groopman, John D.; Johnson, Denise N.; Kensler, Thomas W.

doi:10.3233/cbm-2005-1103

Cited by 84 publications

(73 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These include pre-and post-harvest strategies to prevent mold in food grains, reducing aflatoxin-related illness, and HBV vaccination in high-risk populations. The assessment of exposure to aflatoxin has evolved with the characterization of biomarkers such as aflatoxin-albumin adducts in serum and aflatoxin-N7-guanine in urine (203).…”

Section: Aspergillus and The Hepatitis Virusmentioning

confidence: 99%

Multiple Infections and Cancer: Implications in Epidemiology

Vedham

Divi

Starks

et al. 2014

Technol Cancer Res Treat

View full text Add to dashboard Cite

Approximately 18% of the global cancer burden has been attributed to infectious agents, with estimates ranging from 7% in developed countries to about 22% in developing countries.Chronic infections caused by the hepatitis B and C viruses, human papilloma viruses (HPV), and Helicobacter pylori (H. pylori) are reported to be responsible for approximately 15% of all human cancers. Interestingly, although many of the infectious agents that have been associated with cancer-such as HPV, Epstein-Barr virus (EBV), and H. pylori-are highly prevalent in the world, most infected individuals do not develop cancer but remain lifelong carriers. Malignancies associated with infectious agents may result from prolonged latency as a result of chronic infections. Pathogenic infections are necessary but are not sufficient for cancer initiation or progression. Cancer initiation may require additional cofactors, including secondary infections. Therefore, in patients with chronic infection with one agent, secondary co-infection with another agent may serve as an important co-factor that may cause cancer initiation and progression. Additionally, opportunistic co-infections could significantly inhibit response to cancer treatment and increase cancer mortality. Co-infections are relatively common in areas with a high prevalence of infectious agents, especially in developing countries. These co-infections can cause an imbalance in the host immune system by affecting persistence of and susceptibility to malignant infections. Several articles have been published that focus on infectious agents and cancer. In this article, we discuss the role of infectious agents in malignancies, highlight the role of multiple/co-infections in cancer etiology, and review implications for cancer epidemiology.

show abstract

Section: Aspergillus and The Hepatitis Virusmentioning

confidence: 99%

Multiple Infections and Cancer: Implications in Epidemiology

Vedham

Divi

Starks

et al. 2014

Technol Cancer Res Treat

View full text Add to dashboard Cite

show abstract

“…The correlation among these factors indicates the complexity of hepato-carcinogenesis. Another factor that may affect the development of HCC is aflatoxin B1, which is a carcinogen associated with R249S mutation in the p53 tumor suppressor gene (Groopman et al, 2005). The p53 mutation is extremely prevalent in sub-Saharan Africa and China because of high exposure to aflatoxin (Montesano et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

The KIF1B (rs17401966) Single Nucleotide Polymorphism is not Associated with the Development of HBV-related Hepatocellular Carcinoma in Thai Patients

Sopipong

Tangkijvanich²,

Payungporn³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Hepatitis B virus (HBV) infection can become chronic and if left untreated can progress to hepatocellular carcinoma (HCC).Thailand is endemic for HBV and HCC is one of the top five cancers, causing deaths among Thai HBV-infected males. A single nucleotide polymorphism (SNP) at the KIF1B gene locus, rs17401966, has been shown to be strongly associated with the development of HBV-related HCC. However, there are no Thai data on genotypic distribution and allele frequencies of rs17401966. Thai HBV patients seropositive for HBsAg (n=398) were therefore divided into two groups: a case group (chronic HBV with HCC; n=202) and a control group (HBV carriers without HCC; n=196). rs17401966 was amplified by polymerase chain reaction (PCR) and analyzed by direct nucleotide sequencing. The genotypic distribution of rs174019660 for homozygous major genotype (AA), heterozygous minor genotype (AG) and homozygous minor genotype (GG) in the case group was 49.5% (n=100), 40.1% (n=81) and 10.4% (n=21), respectively, and in controls was 49.5% (n=97), 42.3% (n=83) and 8.2% (n=16). Binary logistic regression showed that rs17401966 was not statistically associated with the risk of HCC development in Thai chronic HBV patients (p-value=0.998, OR=1.00 and 95% CI=0.68-1.48). In conclusion, the KIF1B gene SNP (rs174019660) investigated in this study showed no significant association with HBV-related HCC in Thai patients infected with HBV, indicating that there must be other mechanisms or pathways involved in the development of HCC.

show abstract

“…Both hepatitis B and aflatoxin are independent factors in liver cancer. However, when combined, they act powerfully to raise the risk of hepatic cancer up to 60 times that of unexposed individuals (Groopman et al 2005). This National Institute of Environmental Health Sciences (NIEHS)-funded research is a primary example of the interaction between environ mental health and infectious disease and can serve as a model for future research efforts.…”

Section: Editorialmentioning

confidence: 99%

Note from the Editor: Revised Instructions to Authors

2010

Environ Health Perspect

View full text Add to dashboard Cite

Aflatoxin and hepatitis B virus biomarkers: A paradigm for complex environmental exposures and cancer risk

Cited by 84 publications

References 23 publications

Multiple Infections and Cancer: Implications in Epidemiology

Multiple Infections and Cancer: Implications in Epidemiology

The KIF1B (rs17401966) Single Nucleotide Polymorphism is not Associated with the Development of HBV-related Hepatocellular Carcinoma in Thai Patients

Note from the Editor: Revised Instructions to Authors

Contact Info

Product

Resources

About