The production and availability of food underpins societal stability. In Afghanistan, wheat is the major arable agricultural crop and source of dietary energy. The withdrawal of NATO allies and partner countries from Afghanistan presents numerous well-documented societal and political challenges and has impacts on immediate and longer-term food security. Conflict-impacted irrigation infrastructure coupled with growing climate instability have also contributed markedly to reductions in current food, and specifically wheat, production. Here, we review the status of Afghan wheat improvement and propose a research agenda to support the regeneration of Afghanistan's wheat and agricultural sector.