Affinitychromic Polythiophenes: A Novel Bio-Photonic Tool for High-Throughput Screening and Diagnostics

Leclerc, Mario; Ho, Hoang‐Anh

doi:10.1055/s-2003-44971

Cited by 28 publications

(9 citation statements)

References 93 publications

(136 reference statements)

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“…According to the authors, such bio-photonic toolsÐoptical transducing polythiophenesÐshould create a new generation of useful tools in the areas of diagnostics, therapeutics, and drug screening. [98] All the authors involved in this type of research underline the tremendous potential of polythiophenes as optical sensors for applications in biodiagnostics. In view of that opinion, it seems reasonable to extend efforts on one hand to better characterize the polymers (see the remarks at the end of Sec.…”

Section: G Barbarella Et Al/overview Of Recent Research On Thiophenmentioning

confidence: 99%

The Versatile Thiophene: An Overview of Recent Research on Thiophene‐Based Materials

2005

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In the last few years, thiophene‐based materials, which are semiconductor and fluorescent compounds, have become a highly interdisciplinary field of research, with diverse studies ranging from the fabrication of electronic and optoelectronic devices to the selective detection of biopolymers. This article presents a survey of the papers published in the last two years and concludes with the authors' views on future developments.

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Section: G Barbarella Et Al/overview Of Recent Research On Thiophenmentioning

confidence: 99%

The Versatile Thiophene: An Overview of Recent Research on Thiophene‐Based Materials

2005

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“…[26] As shown above, conjugated polymers can form ordered monolayers, and chemical sensors utilizing conjugated polymers may show greater sensitivity than small molecules. [124][125][126] The principle behind most of this work is that interactions between the Organic Nanomaterials Angewandte Chemie analyte and the polymer induce a change in the conformation of the polymer chain which in turn affects its electrical and optical properties. These interactions are detected as changes in the conductivity, redox behavior (measured by cyclic voltammetry), absorption, or fluorescence of the polymer.…”

Section: Conjugated Polymers For Chemical Sensorsmentioning

confidence: 99%

The Chemistry of Organic Nanomaterials

2005

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The development of nanotechnology using organic materials is one of the most intellectually and commercially exciting stories of our times. Advances in synthetic chemistry and in methods for the investigation and manipulation of individual molecules and small ensembles of molecules have produced major advances in the field of organic nanomaterials. The new insights into the optical and electronic properties of molecules obtained by means of single-molecule spectroscopy and scanning probe microscopy have spurred chemists to conceive and make novel molecular and supramolecular designs. Methods have also been sought to exploit the properties of these materials in optoelectronic devices, and prototypes and models for new nanoscale devices have been demonstrated. This Review aims to show how the interaction between synthetic chemistry and spectroscopy has driven the field of organic nanomaterials forward towards the ultimate goal of new technology.

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“…Leclerc and Ho [21] described the thermochromic, ionochromic, and affinitychromic properties of various neutral conjugated polymers. These optical features, based on a conformational modification of the conjugated backbone induced from side-chain order/disorder transition, have led to interesting colorimetric and/or fluorimetric transducers for various chemosensor and biosensor applications.…”

Section: Reviewsmentioning

confidence: 99%

Optical Chemical Biosensors for High Throughput Screening of Drugs

Bosch

Ruiz-Sánchez²,

Rojas³

et al. 2007

CCHTS

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Optical biosensors have been commercially available since the early 1990s, and have been used extensively in many areas of research in the life sciences. Optical biosensors developed for drug analysis generally exploit the high selectivity of the antigen-antibody and drug-protein interaction. Optical biosensors can be made based on optical diffraction or electro-chemiluminescence. High-throughput screening, (HTS) which includes automated preparation of a large number of samples and then screening of their properties in multi-well plates, improves the efficiency of research in many scientific areas, e.g., catalyst screening, food processing, chemical synthesis, drug discovery, absorption, distribution, metabolism, and excretion and toxicological and cell based screening. The three most common detection techniques used in HTS are UV-VIS absorbance, fluorescence and luminescence. In this review, we summarize some recent trends and developments in the construction of optical chemical biosensors used in high-throughput screening of drugs. Also, we have included environmental, biological and other medical applications of biosensors.

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Affinitychromic Polythiophenes: A Novel Bio-Photonic Tool for High-Throughput Screening and Diagnostics

Cited by 28 publications

References 93 publications

The Versatile Thiophene: An Overview of Recent Research on Thiophene‐Based Materials

The Versatile Thiophene: An Overview of Recent Research on Thiophene‐Based Materials

The Chemistry of Organic Nanomaterials

Optical Chemical Biosensors for High Throughput Screening of Drugs

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