Affinity sensor based on immobilized molecular imprinted synthetic recognition elements

Lenain, Pieterjan; Saeger, Sarah De; Mattìasson, Bo; Hedström, Martin

doi:10.1016/j.bios.2015.02.016

Cited by 33 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, detection of these molecules in a sensitive, cheap, robust and fast way is crucial. Lenain et al [23] chose metergoline as a model compound representingsmall organic molecules such as pharmaceutical residues. Emulsion polymerization was used to produce small, uniformly sized, spherical MIPs.…”

Section: Different Applications Of Capacitive Biosensorsmentioning

confidence: 99%

See 1 more Smart Citation

Capacitive Biosensors and Molecularly Imprinted Electrodes

Ertürk

Mattìasson

2017

Sensors

Self Cite

View full text Add to dashboard Cite

Abstract:Capacitive biosensors belong to the group of affinity biosensors that operate by registering direct binding between the sensor surface and the target molecule. This type of biosensors measures the changes in dielectric properties and/or thickness of the dielectric layer at the electrolyte/electrode interface. Capacitive biosensors have so far been successfully used for detection of proteins, nucleotides, heavy metals, saccharides, small organic molecules and microbial cells. In recent years, the microcontact imprinting method has been used to create very sensitive and selective biorecognition cavities on surfaces of capacitive electrodes. This chapter summarizes the principle and different applications of capacitive biosensors with an emphasis on microcontact imprinting method with its recent capacitive biosensor applications.

show abstract

Section: Different Applications Of Capacitive Biosensorsmentioning

confidence: 99%

“…From left to right, top to bottom: ( a ) SEM picture of electrode surface; ( b , c ) SEM pictures of centre of the electrode; and ( d ) SEM picture of the border between the gold layer and wafer. (Reproduced from Reference [23] with permission).…”

Section: Figurementioning

confidence: 99%

Capacitive Biosensors and Molecularly Imprinted Electrodes

Ertürk

Mattìasson

2017

Sensors

Self Cite

View full text Add to dashboard Cite

show abstract

“…One such example of a successful optimization is shown in Fig. 16 illustrating the binding of metergoline to a capacitive biosensor [40]. The sensitivity was in the micromolar range, but in this case regeneration took place spontaneously when the loaded MIP was exposed to plain water.…”

Section: Elutionmentioning

confidence: 98%

MIPs as Tools in Environmental Biotechnology

Mattìasson

2015

Molecularly Imprinted Polymers in Biotechnology

Self Cite

View full text Add to dashboard Cite

Molecular imprints are potentially fantastic constructions. They are selective, robust, and nonbiodegradable if produced from stable polymers. A range of different applications has been presented, everything from separation of enantiomers, via adsorbents for sample preparation before analysis to applications in wastewater treatment. This chapter deals with molecularly imprinted polymers (MIPs) as tools in environmental biotechnology, a field that has the potential to become very important in the future.

show abstract

“…One of the main advantages of the electropolymerization technique is that the thickness of the MIP film layer can be changed by applying different voltage values. Lenain and co-workers [32] first prepared an electrode composed of molecularly imprinted sub-micron spherical particles for the recognition of metergoline. Hybrid structures can also be prepared by using MIPs with proteins or a self-assembled monolayer.…”

Section: Mip Based-quartz Crystal Microbalance (Qcm) Sensorsmentioning

confidence: 99%

Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors

Di̇ltemi̇z

Keçili

Ersöz

et al. 2017

Sensors

View full text Add to dashboard Cite

Molecularly imprinted polymers (MIPs) as artificial antibodies have received considerable scientific attention in the past years in the field of (bio)sensors since they have unique features that distinguish them from natural antibodies such as robustness, multiple binding sites, low cost, facile preparation and high stability under extreme operation conditions (higher pH and temperature values, etc.). On the other hand, the Quartz Crystal Microbalance (QCM) is an analytical tool based on the measurement of small mass changes on the sensor surface. QCM sensors are practical and convenient monitoring tools because of their specificity, sensitivity, high accuracy, stability and reproducibility. QCM devices are highly suitable for converting the recognition process achieved using MIP-based memories into a sensor signal. Therefore, the combination of a QCM and MIPs as synthetic receptors enhances the sensitivity through MIP process-based multiplexed binding sites using size, 3D-shape and chemical function having molecular memories of the prepared sensor system toward the target compound to be detected. This review aims to highlight and summarize the recent progress and studies in the field of (bio)sensor systems based on QCMs combined with molecular imprinting technology.

show abstract

Affinity sensor based on immobilized molecular imprinted synthetic recognition elements

Cited by 33 publications

References 21 publications

Capacitive Biosensors and Molecularly Imprinted Electrodes

Capacitive Biosensors and Molecularly Imprinted Electrodes

MIPs as Tools in Environmental Biotechnology

Molecular Imprinting Technology in Quartz Crystal Microbalance (QCM) Sensors

Contact Info

Product

Resources

About