Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis

Luxton, Richard; Zeman, Adam; Holzel, Helen; Harvey, P.; Wilson, John; Kocen, R S; Morgan‐Hughes, J. A.; Miller, D. H.; Compston, Alastair; Thompson, Edward J.

doi:10.1016/0022-510x(95)00115-i

Cited by 44 publications

(32 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Quantitative neurological score CDMS patients having a sib with at least two CSF-enriched OCBs (n=9) and those without (n=38) had essentially the same median RFSS [18], of 11.77 and 10.53 (P=0.4).…”

Section: Measles History and Vaccination Statusmentioning

confidence: 73%

Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls

et al. 2000

View full text Add to dashboard Cite

We found that 19% (9/47) of healthy siblings of patients with clinically definite multiple sclerosis had an intrathecal immunological reaction with two or more 2 CSF-enriched oligoclonal bands (OCBs), in contrast to (4%) (2/50) unrelated healthy controls. Furthermore, in this group of nine healthy sibs the measles CSF IgG antibody titers were higher than that of the other sibs and that of controls. There were also differences in the serum titers for measles IgG antibody, which were higher in the group of all healthy sibs than in healthy volunteers, and (as with CSF titers) higher in the subgroup of healthy sibs with two or more 2 CSF-enriched OCBs than the other sibs. Thus a significant proportion of healthy siblings to MS patients have a partially hyperimmune condition similar to that occurring in MS, which in 19% manifested itself as an OCB reaction, in 9% as increased CSF measles IgG antibody titers, and in 21% as increased serum measles IgG antibody titers, these phenomena tending to occur in the same individuals. This condition is characterized by CSF-enriched OCBs with undefined specificity, although some increased antiviral reactivity is found both in the serum and CSF. While it needs further characterization, a genetic trait interacting with common infections is suggested. The recurrence risk of this condition is approximately five times higher than the 3-4% recurrence risk for manifest MS reported for sibs.

show abstract

Section: Measles History and Vaccination Statusmentioning

confidence: 73%

Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls

et al. 2000

View full text Add to dashboard Cite

show abstract

“…This polyspecific Ig response is of low affinity [9] and is not represented by the major oligoclonal bands of MS patients [6]. In contrast, in viral encephalitis or neuroborreliosis high-affinity antigenspecific IgG are found [7,9].…”

Section: Introductionmentioning

confidence: 85%

“…Any analysis of virus-specific intrathecal Ig production of MS-patients has to take into consideration that typically MS patients, but not patients with neuroinfections display a polyspecific intrathecal Ig production against a number of different pathogens [6,14]. This polyspecific Ig response is of low affinity [9] and is not represented by the major oligoclonal bands of MS patients [6]. In contrast, in viral encephalitis or neuroborreliosis high-affinity antigenspecific IgG are found [7,9].…”

Section: Introductionmentioning

confidence: 91%

Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B–cell response

2005

View full text Add to dashboard Cite

Human herpesvirus 6 (HHV-6) is one of many infectious agents that have been implicated in the pathogenesis of multiple sclerosis (MS). Intrathecal immunoglobulin (Ig) production with oligoclonal CSF bands are hallmarks of both MS and infections of the CNS. In neuroinfections the intrathecal Ig production is directed largely against the respective agent, while MS patients mount an intrathecal Ig production against different pathogens. In this study a total of 77 serum/CSF pairs were first analyzed for an intrathecal immune response against HHV-6. We found that 21% of the MS patients, but none of the control donors showed an intrathecal immunoglobulin (Ig) response against HHV-6 (p = 0.017). Patients with such an intrathecal Ig production had a significantly higher total amount of Ig (p = 0.007) and a higher cell number in the CSF (p = 0.03). In a second step, four of the MS-patients who showed a strong intrathecal Ig production against HHV-6 were examined for immune reactivity against other viruses (human herpesvirus type 1, measles virus, human cytomegalovirus, rubella virus, varicella zoster virus). All of these patients had an intrathecal Ig production against at least one other, unrelated virus. Together, our findings strongly argue that in the majority of MS patients without an intrathecal Ig response to HHV-6 (about 80 % in our study), this virus is not involved in the pathogenesis. In the other 20% the intrathecal Ig production to HHV-6 might reflect reactivation of HHV-6 or could be part of a polyspecific B cell activation.

show abstract

“…Another characteristic of MS is the polyspecific low affinities of the oligoclonal IgG intrathecally produced [15]. In this study, we therefore incubated the blots with varying concentrations of the chaotropic agent, NaSCN, to determine the affinity of any IgG detected.…”

Section: Discussionmentioning

confidence: 99%

No Evidence for Production of Intrathecal Immunoglobulin G against <i>Acinetobacter</i> or <i>Pseudomonas</i> in Multiple Sclerosis

Chapman

Hughes²,

Wilson³

et al. 2004

Eur Neurol

View full text Add to dashboard Cite

The production of oligoclonal, polyspecific immunoglobulin G is characteristic of multiple sclerosis (MS), yet no pathogen has been identified as an infectious agent. Recent studies have proposed Acinetobactercalcoaceticus and Pseudomonas aeruginosa as candidate organisms, on the basis of a sequence homology between a bacterial enzyme and bovine myelin basic protein. To investigate this, we looked for specific, high-affinity immunoglobulin G against these pathogensin paired serum and cerebrospinal fluid from MS patients compared to other neurological diseases. We found no greater incidence of high-affinity antibodies against the organisms studied in MS vs. other neurological diseases, and so conclude that A. calcoaceticus and P. aeruginosa are unlikely to be implicated in the pathogenesis of MS.

show abstract

Affinity of antigen-specific IgG distinguishes multiple sclerosis from encephalitis

Cited by 44 publications

References 18 publications

Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls

Incidence of CSF abnormalities in siblings of multiple sclerosis patients and unrelated controls

Intrathecal antibody (IgG) production against human herpesvirus type 6 occurs in about 20% of multiple sclerosis patients and might be linked to a polyspecific B–cell response

No Evidence for Production of Intrathecal Immunoglobulin G against <i>Acinetobacter</i> or <i>Pseudomonas</i> in Multiple Sclerosis

Contact Info

Product

Resources

About