Affinity ligands for immunoglobulins based on the multicomponent Ugi reaction

Haigh, Jonathan; Hussain, Abid; Mimmack, Michael L.; Lowe, Christopher R.

doi:10.1016/j.jchromb.2009.03.010

Cited by 56 publications

(60 citation statements)

References 42 publications

(59 reference statements)

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“…Stationary phases modified with Ugi molecules have been recently introduced to efficiently separate immunoglobulins (Igs). [49] Currently, more than 300 monoclonal antibodies (mAbs) are moving toward the market. However, the efficient and highyielding cleaning of the raw fermentation brew is still a holy grail in technical antibody processing.…”

Section: Wwwtcrwiley-vchde 989mentioning

confidence: 99%

Multicomponent Reactions, Union of MCRs and Beyond

Zarganes‐Tzitzikas

Chandgude

Dömling

2015

The Chemical Record

222

137

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Multicomponent reactions (MCRs), which are located between one- and two-component and polymerization reactions, provide a number of valuable conceptual and synthetic advantages over stepwise sequential approaches towards complex and valuable molecules. To address current limitations in the number of MCRs and the resulting scaffolds, the concept of union of MCRs was introduced two decades ago by Dömling and Ugi and is rapidly advancing, as is apparent by several recently published works. MCR technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry in addition to academia. Clearly, novel scaffolds accessible in few steps including MCRs will further enhance the field of applications. Additionally, broad expansion of MCR applications in fields such as imaging, materials science, medical devices, agriculture, or futuristic applications in stem cell therapy and theragnostics or solar energy and superconductivity are predicted.

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Section: Wwwtcrwiley-vchde 989mentioning

confidence: 99%

Multicomponent Reactions, Union of MCRs and Beyond

Zarganes‐Tzitzikas

Chandgude

Dömling

2015

The Chemical Record

222

137

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“…Using the hydrophobic core dipeptide Phe132-Tyr133 as a starting point, a novel triazine mimetic was rationally designed, synthesized and utilized for purification of antibodies . Since then, mimetics have also been developed for other antibody-binding proteins using modified synthetic molecular scaffolds and chemistries (Haigh et al 2009;Lowe 2001;Roque et al 2005). The SPA mimetic peptide PAM is another example of a protein A mimetic ligand.…”

Section: Miniaturization and Protein Mimickingmentioning

confidence: 99%

Purification Systems Based on Bacterial Surface Proteins

Boström¹,

Nilvebrant²,

Hober³

2012

Protein Purification

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“…The affinity ligand library was constructed according to the methods developed previously [1,11,14]. Briefly, Sepharose 4B was first activated with epichlorohydrin, and then with saturated ammonia.…”

Section: Solid-phase Synthesis Of Affinity Materialsmentioning

confidence: 99%

Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins

Cheng

et al. 2011

J of Separation Science

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Affinity chromatography has played an increasingly important role both in the pharmaceutical industry and academic research. In the present study, we report our preliminary investigation on the relationship between the affinity ligand structure and its adsorption to multi-protein samples. The structure of the ligands, including the size of the ring (cyclic group) and the length of the chain (linear group), has a great impact on the adsorption of ligands to proteins. Meanwhile, the functional groups that the ligands carry are also closely related to the adsorption of ligands to proteins. This research provides good guidance for the design and synthesis of affinity materials in affinity chromatography. It is also useful to other protein-ligand interaction-related research.

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Affinity ligands for immunoglobulins based on the multicomponent Ugi reaction

Cited by 56 publications

References 42 publications

Multicomponent Reactions, Union of MCRs and Beyond

Multicomponent Reactions, Union of MCRs and Beyond

Purification Systems Based on Bacterial Surface Proteins

Design and synthesis of affinity ligands and relation of their structure with adsorption of proteins

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