Affinity enhancement of polo-like kinase 1 polo box domain-binding ligands by a bivalent approach using a covalent kinase-binding component
Kohei Tsuji,
Hirokazu Tamamura,
Terrence R. Burke
Abstract:A bivalent approach for targeting polo-like kinase 1 (Plk1) kinase domain and polo-box domain simultaneously provides dramatically enhanced affinity ligands of Plk1 even with the use of a non-selective ATP-competitive inhibitor.
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