Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex II. In purkyně cells

Eccles, John C.; Faber, Donald S.; Murphy, John T.; Sabah, Nassir H.; Táboríková, H

doi:10.1007/bf00236429

Cited by 54 publications

(16 citation statements)

References 36 publications

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“…Similarly the latency of h2 (9.6 + 1-2 msec from the forelimb nerves and 117 + I 0 msec from the hind limb nerves, Table 1) agrees approximately with 6-11 and 10-15 msec given for the latency of activation of Purkyn6 cells through the mossy fibres (Eccles, Faber, Murphy, Sabah & Tabofikova', 1969, 1971a. Thus d, and h2 appear to be produced through the mossy fibre system; d4 directly and h2 as a consequence of Purkyn6 cell activation.…”

Section: Action Of Mossy Afferents On Deiters Resultssupporting

confidence: 76%

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the mossy fibre afferents

Allen¹,

Sabah²,

Toyama³

1972

The Journal of Physiology

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SUMMARY1. The cerebellar integration of sensory inputs to Deiters neurones was investigated in decerebrate cats. In some preparations decerebration was combined with transection of the olivocerebellar fibres.2. In the latter preparations peripheral nerve impulses generally produced a response consisting of a sequence of the following post-synaptic3. The mean latencies of dj, hl and h2 were 5 7, 7-3 and 9-8 msec from the forelimb nerves, and 7 5, 9 0 and 13-4 msec from the hind limb nerves, respectively.4. The stimulus intensity-response relation indicates that the Group I muscle afferents as well as the low threshold cutaneous afferents contribute to the response.5. In the preparations with the intact inferior olive there were additional components of the post-synaptic potentials: a later e.p.s.p. (d2) and another later i.p.s.p. (h3), their mean latencies being 15-3 and 19-7 msec from the forelimb nerves, and 18-0 and 21t3 msec from the hind limb nerves, respectively.6. The d1 and h2 components were attributed to the mossy fibre afferents and d2 and h3 to the climbing fibres; d, and d2 were due to excitation through the collaterals of the mossy and climbing fibres, and h2 and h3 to inhibition from Purkyn6 cells activated by the mossy and climbing fibres, respectively. h1 was too early to be produced through the cerebellum, and was probably mediated by inhibitory neurones in the reticular formation.

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Section: Action Of Mossy Afferents On Deiters Resultssupporting

confidence: 76%

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the mossy fibre afferents

Allen¹,

Sabah²,

Toyama³

1972

The Journal of Physiology

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“…The precise patterns of response elicited in each Purkinje cell by stimulation of individual trigeminal branches and the combination of effective afferent sources varied widely, in a manner analogous to that seen for limb inputs on Purkinje cells in the pars intermedia (Eccles et al 1971).…”

Section: Organization Of Trigeminal Projectionsmentioning

confidence: 86%

“…The depression of simple spike activity following a climbing fibre response served to indicate that both types of discharge were generated by the same cell (Eccles et al 1971;Latham & Paul, 1971). Post-stimulus time histograms of the responses were constructed from either thirty-two or sixty-four trials (256 addresses, 2 msec in width).…”

Section: Methodsmentioning

confidence: 99%

“…Collectively these results emphasize the similarity of the pattern of the trigeminal projection to lobules HV, HVI and HVIIA to that of limb afferents to the anterior lobe (Eccles et at. 1968a;Eccles et al 1971) and thus imply a common mode of cerebellar processing of sensory information. It has been postulated that a major function of the sensory input to the intermediate zone of the cerebellar cortex is in monitoring continuously the progress of 'on-going' movements and thereby to participate in 'on-line' correction (Eccles, 1973).…”

Section: Pathways Mediating Trigemino-cerebellar Responsesmentioning

confidence: 99%

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Mossy and climbing fibre mediated responses evoked in the cerebellar cortex of the cat by trigeminal afferent stimulation.

Cody¹,

Richardson²

1979

The Journal of Physiology

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SUMMARY1. The trigeminal input to the cerebellar cortex was studied by recording mass and unitary responses evoked by electrical stimulation of individual trigeminal cutaneous and muscle nerve branches, in cats lightly anaesthetized with sodium thiopentone.2. The trigeminal projection area of the cerebellar cortex comprised essentially lobule HVI, but included adjacent folia of lobules HV and HVIIA.3. Each trigeminal branch had a 'patchy' representation throughout the projection area and there was extensive convergence of individual afferents at each site. Exact combinations of convergent inputs varied between loci, the projection from the muscle nerve 7. Response patterns comprised one or more of the following: short latency (3-8 msec) simple, mossy fibre-mediated spikes, 'delayed' (10-25 msec) simple spikes and climbing fibre-mediated multiple spike bursts (9-35 msec).

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“…(Table 1). Eccles et al 1969Eccles et al , 1971a, after allowing about 1 msec for impulse conduction and synaptic delay from Purkyn6 cell to the Deiters neurone (Ito & Yoshida, 1966 Fig. 5A shows the response in an HL cell to conditioning IO stimulation (S1 in Fig.…”

Section: Resultsmentioning

confidence: 99%

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the climbing fibre afferents

Allen¹,

Sabah²,

Toyama³

1972

The Journal of Physiology

Self Cite

View full text Add to dashboard Cite

Afferent volleys in limb nerves influencing impulse discharges in cerebellar cortex II. In purkyně cells

Cited by 54 publications

References 36 publications

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the mossy fibre afferents

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the mossy fibre afferents

Mossy and climbing fibre mediated responses evoked in the cerebellar cortex of the cat by trigeminal afferent stimulation.

Synaptic actions of peripheral nerve impulses upon Deiters neurones via the climbing fibre afferents

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