Afferent signaling impairment from baroreceptors cannot fully explain decrease in heart rate variability in Marfan syndrome patients: an author’s reply

Cherkas, Andriy; Zhuraev, Rustam

doi:10.5603/cj.2016.0014

Cited by 1 publication

(1 citation statement)

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“…Parasympathetic activity is known to have anti-inflammatory properties, and various ways of vagal nerve output stimulation may reduce inflammatory responses in numerous animal models. The clinical importance of HRV decrease in terms of mechanisms and practical implications have been also recently discussed ( 19 ). These findings require further human studies in order to translate their results into medical practice ( 20 ), however, it is clear that the high activity of the parasympathetic nervous system provides numerous benefits for the organism and its suppression places the individual at risk.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori in sedentary men is linked to higher heart rate, sympathetic activity, and insulin resistance but not inflammation or oxidative stress

et al. 2016

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AimTo compare anthropometric parameters, body composition, hormonal and inflammatory profiles, oxidative stress indices, and heart rate variability (HRV) in Heliobacter pylori (H.pylori) positive and negative healthy sedentary participants.MethodsAmong 30 recruited apparently healthy male participants (age between 20 and 40) enrolled in this cross-sectional study, 18 were H.pylori negative and 12 were positive (stool antigen test). Participants underwent routine physical examination and body composition determination. The following biochemical parameters were determined in blood: fasting whole blood glucose, glycated hemoglobin, insulin, C-peptide, cortisol, aldosterone, testosterone, thyroid stimulating hormone, C-reactive protein, interleukins 6 and 10, tumor necrosis factor-α, and the urinary level of 1,4-dihydroxynonane mercapturic acid. For HRV evaluation, electrocardiogram in supine position and in orthostatic test was performed.ResultsH.pylori contamination was not significantly associated with any changes in anthropometric parameters, body composition, blood pressure, fasting glucose, or glycated hemoglobin levels. No significant difference was found for inflammatory markers as well as 1,4-dihydroxynonane mercapturic acid. H.pylori-positive participants, however, had significantly higher heart rate (P = 0.009), sympathetic/parasympathetic balance in orthostatic test (P = 0.029), fasting insulin level (P = 0.037), and HOMA-index (P = 0.047).ConclusionsH.pylori contamination is linked to a significantly higher heart rate, sympathetic activation, and increased insulin resistance, while inflammatory and oxidative stress markers remain unaffected in healthy sedentary male subjects.

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Section: Discussionmentioning

confidence: 99%