Afferent projections to the preoptic area and hypothalamic regions in the rat brain

Berk, Mitchell L.; Finkelstein, James D.

doi:10.1016/0306-4522(81)90227-x

Cited by 301 publications

(87 citation statements)

References 42 publications

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“…Indeed, the AH of golden hamsters is known to receive afferents from the LS [Ferris et al, 1990a] and amygdala [Kevetter and Winans, 1981;Gomez and Newman, 1992;Coolen and Wood, 1998]. Furthermore, the present description of areas projecting to the AH of hamsters is also consistent with previous reports in rats or guinea pigs [Meibach and Siegel, 1977;Krettek and Price, 1978;Swanson and Cowan, 1979;Berk and Finkelstein, 1981;Sakanaka et al, 1981;Kita and Oomura, 1982;Tribollet et al, 1985;Staiger and Nürnber-ger, 1991;Thellier et al, 1994;Cameron et al, 1995;Ricciardi et al, 1996]. In addition, the present description of the efferent projections of the AH is also consistent with previous observations in golden hamsters [Morin et al, 1994].…”

Section: Discussionsupporting

confidence: 82%

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

2000

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In male golden hamsters, offensive aggression is regulated by an interaction between arginine-vasopressin and serotonin at the level of the anterior hypothalamus. The present studies were conducted to study a neural network underlying this interaction. The connections of the anterior hypothalamus were examined by retrograde and anterograde tracing in adult male hamsters. Several limbic areas were found to contain both types of tracing suggesting reciprocal connections with the anterior hypothalamus. Their functional significance relating to the consummation of aggression was tested by comparing neuronal activity (examined through quantification of c-Fos-immunolabeling) in two groups of animals. Experimental animals were sacrificed after attacking an intruder. Control animals were sacrificed after exposure to a woodblock carrying the odor of an intruder that elicited behaviors related to offensive aggression without its consummation. An increased density of Fos-immunoreactivity was found in experimental animals within the medial amygdaloid nucleus, ventrolateral hypothalamus, bed nucleus of the stria terminalis and dorsolateral part of the midbrain central gray. These data suggest that these areas are integrated in a neural network centered on the anterior hypothalamus and involved in the consummation of offensive aggression. Finally, c-Fos-immunoreactivity was combined with labeling of serotonin and vasopressin neurons to identify sub-populations particularly associated with offensive aggression. Vasopressin neurons in the nucleus circularis and medial division of the supraoptic nucleus showed increased neuronal activity in the fighters, supporting their role in the control of offensive aggression.

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Section: Discussionsupporting

confidence: 82%

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

2000

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“…A projection from the lateral habenula to the lateral margin of the DM has been described in the monitor lizard, Varanus [Distel and Ebbesson, 19811 and is con firmed by our results. This reptilian projection is in general agreement with pathways found in mammals [Herkcnham and Nauta, 1979;Berk and Finkelstein, 1981], although these mammalian studies also reported a light projection from the lateral habenula to the lateral hypothalamus which has not been observed in reptiles. Evidence suggesting a light projection from the ventral habenula to the hypothala mus in frogs was presented by Neaiy [ 19951. Rhombencephalon.…”

Section: Comparisons With Amphibians and Mammalssupporting

confidence: 77%

“…Rodents also have projections from the lateral septal nucleus through the medial forebrain bundle to the DMH, VMM. and lateral hypothalamic area [Swanson andCowan, 1979: Berk andFinkelstein. 1981] which appear to be very similar to the lateral septal projec tions to the hypothalamus of geckos.…”

Section: Comparisons With Amphibians and Mammalsmentioning

confidence: 99%

Afferent Projections to the Lateral and Dorsomedial Hypothalamus in a Lizard, <i>Gekko gecko</i>

Bruce

Neary

1995

Brain Behav Evol

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Afferent projections to the lateral hypothalamic area and dorsomedial hypothalamic nucleus of the lizard Gekko gecko were studied after applications of wheat germ agglutinin conjugated to horseradish peroxidase. Large applications into the hypothalamus labeled several telencephalic populations not observed after smaller injections. These included the rostrolateral area of the dorsal cortex, a sheet of cells deep to the caudal pole of the lateral cortex, the external amygdala, and part of the dorsal ventricular ridge. Other populations were labeled in the diencephalon, including the supraoptic nucleus and nucleus ovalis; in the medulla the medial reticular area was labeled. Injections into the lateral hypothalamic area labeled neurons in the rostrolateral dorsal cortex, anterior, lateral, and dorsal septal nuclei, the striatoamygdalar area, nucleus accumbens, vertical limb of the diagonal band, nucleus of the accessory olfactory tract, the interstitial, ventral anterior, and ventral posterior amygdalar nuclei, several hypothalamic nuclei, and the posteroventral thalamic nucleus. Labeled brainstem populations included the ventral tegmental area, torus semicircularis, parvocellular and ventral isthmal nuclei, superior raphe, and the solitary nucleus. Injections in the dorsomedial hypothalamic nucleus labeled neurons in the rostral and caudolateral poles of the dorsal cortex, anterior septal nucleus, horizontal limb of the diagonal band, nucleus of the anterior commissure, several hypothalamic areas, the lateral habenula, the posteroventral thalamic nucleus, and cells scattered around the dorsolateral anterior thalamic nuclei. Labeled brainstem populations included the torus semicircularis, ventral tegmental area, superior raphe, parvocellular and ventral isthmal nuclei, and the lateral dorsal tegmental nucleus. The results of these studies are compared with findings in amphibians and mammals.

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“…Brain regions within the social behavior network are colored yellow, brain regions in the mesolimbic reward system are colored blue, and brain regions shared by both networks are colored green. Mammals: Siegel et al, 1971;Ungerstedt, 1971;Conrad and Pfaff, 1975;Saper et al, 1976;Meibach and Siegel, 1977;Krettek and Price, 1978;Phillipson, 1979;Swanson andCowan, 1977, 1979;Berk and Finkelstein, 1981;Kelley et al, 1982;Eberhart et al, 1985;Haber et al, 1985;Yang and Mogenson, 1985;Caffe et al, 1987;Domesick, 1988;Groenewegen et al, 1993;Canteras et al, 1994;Napier et al, 1995;Numan and Numan, 1996;Pikkarainen et al, 1999;Carr and Sesack, 2000;Morgane et al, 2005. Birds: Berk andButler, 1981;Cheng et al, 1987;Wild, 1987;Berk, 1991;Balthazart and Absil, 1997;Medina and Reiner, 1997;Absil et al, 2002;Atoji et al, 2002Atoji et al, , 2006Atoji and Wild, 2004;Montagnese et al, 2008.…”

Section: Social Behavior Networkmentioning

confidence: 99%

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

851

879

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All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

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Afferent projections to the preoptic area and hypothalamic regions in the rat brain

Cited by 301 publications

References 42 publications

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

Neural Connections of the Anterior Hypothalamus and Agonistic Behavior in Golden Hamsters

Afferent Projections to the Lateral and Dorsomedial Hypothalamus in a Lizard, <i>Gekko gecko</i>

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

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