Afferent projections to the dorsal motor nucleus of the vagus

Roges, Richard C.; Kita, Hitoshi; Butcher, Larry L.; Novin, Donald

doi:10.1016/s0361-9230(80)80006-2

Cited by 112 publications

(42 citation statements)

References 40 publications

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“…These rpc connections were also described by Rogers et al [32], although these projections in our material appear to be more extensive. It was shown in our experiments that the ventrolateral aspect of the rpc is a source of afferents to the dmnX and amb, whereas the ventrolateral rpc also seems to be a major recipient of efferent connections from lh, dmh and vmh.…”

Section: Discussionsupporting

confidence: 88%

“…However, as a result of the large size of the tracer injections employed by these authors it proved to be difficult to localize specifically the cell groups in the lh that give rise to the descending medullary connections. Hypothalamus connections directly aimed at the dmnX have also been identified in retrograde transport studies [32]. These authors, however, describe the pv as the only hypothalamic locus of retrogradely labeled somata after dmnX injections of HRP, but do not describe labeling in other nuclei of the hypothalamus.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat

Horst

Luiten

Kuipers

1984

Journal of the Autonomic Nervous System

179

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat

Horst

Luiten

Kuipers

1984

Journal of the Autonomic Nervous System

179

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“…It has been reported that a high-affinity All binding occurs at presynaptic sites in the NST where the vagal afferent fibres terminate, as well as at postsynaptic sites in the DMV (Diz, Barnes & Ferrario, 1986). Anatomic studies have shown that the DMV receives massive projections from the NST (Rogers, Kita, Butcher & Novin, 1980). Since the synaptic inputs from the NST to the DMV were considered to be preserved in the slice preparations (Fukuda et al 1987), the transsynaptic effects of All on the DMV neurones mav be mediated bv its action on the neurones in the NST.…”

Section: Discussionmentioning

confidence: 99%

Effects of vasopressin and angiotensin II on neurones in the rat dorsal motor nucleus of the vagus, in vitro.

Katafuchi

Muratani

et al. 1992

The Journal of Physiology

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SUMMARY1. Extracellular recordings were made from 297 spontaneously firing neurones in the dorsal motor nucleus of the vagus (DMV) in slice preparations of rat medulla oblongata. Some of the neurones recorded were identified to be vagal motoneurones by antidromic stimulation. The cells fired with a slow irregular pattern at an average rate of 1 1 + 041 spikes/s (mean + S.E.M.).2. Arginine vasopressin (AVP) was applied by perfusion in 196 of the 297 cells. Most of the neurones (190/196, 97 %) were excited by 10-6 M AVP with an increase in firing rate from the basal level of 11 + 0-1 to a maximum of 2-5 + 0-2 spikes/s. There was a dose-dependent relation between the concentration of AVP and the increased firing rate in all DMV neurones tested (n = 38). The threshold concentration of the peptide to produce changes in firing rate was assumed to be about 10-10 M. The remaining six neurones were not affected by application of AVP.3. Application of oxytocin (OXT, 10-6 M) increased the firing rate of all thirtyeight neurones tested. The effects of AVP and OXT on all neurones examined (n = 20 and 4, respectively) still persisted after blocking the synaptic transmission in a low-Ca2+ or Ca2+-free-high-Mg2+ solution, indicating the direct action of both AVP and OXT on the postsynaptic membranes.4. The AVP-induced excitatory responses were completely but reversibly blocked by the Vl-type receptor antagonists, [1-(,f-mercapto-/,,i-cyclopentamethylene-(n = 5) and Phaa-D-Tyr(Et)Phe-Gln-Asn-Lys-Pro-Arg-NH2 (n = 6), whereas a selective and reversible OXT receptor antagonist, desGly-NH2d(CH2)jTyr-(Me)2Thr4]ornithine vasotocin, which suppressed the OXT-induced excitation, did not block the responses to AVP (n = 11). 5. Application of angiotensin II (AII, 10-6 M) to 153 neurones increased the firing rates of 60 (39%) neurones. The firing rate was increased from the basal level of 1-0+041 to a maximum of 1-8+0-2 spikes/s (n = 60). The effect of All was completely abolished by an All receptor antagonist, [Sarl,lle8]angiotensin II (n = 6). There was a dose dependence of the excitatory response on All concentration in all of eleven neurones tested. The threshold concentration was assumed to be about MS 9206 Z -L. MO AND OTHERS 10-9 M. The activity of 5 (3 %) of 153 neurones was decreased, and the remaining 88 (58%) neurones were not affected by AII.6. After blocking synaptic transmission with low-Ca2+-high-Mg2+ medium, ten of sixteen neurones that had been excited by application of All in normal medium still responded to All, and the effects were abolished in the remaining six cells.7.Of fifty-nine cells tested with both AVP and AII applied at 10-6 M, responses of fifty-four (92 %) to AVP were excitation. Of these fifty-four, fifteen were also excited by application of All, one was inhibited, and All had no effect on the remaining thirty-eight (70 %).8. The excitatory responses induced by AVP were completely or partially blocked by simultaneous perfusion of All in normal medium, which were restored by [Sarl,lle8]AII, whereas the appli...

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“…Electrophysiological and neuroanatomical evidence suggests that this 5-hydroxytryptaminergic input originates from raphe nuclei (Rogers et al, 1980;Thor & Helke, 1987) and is involved in the central control of gastrointestinal and cardiovascular systems. In the rat, i.v.…”

Section: Introductionmentioning

confidence: 99%

The effect of 5‐HT and selective 5‐HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro

Albert

Spyer

Brooks

1996

British J Pharmacology

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1 Whole-cell patch-clamp recordings were made from 142 visually identified rat dorsal vagal preganglionic neurones (DVMs). Applications of 5-hydroxytryptamine (5-HT, 20 guM, 2 min) elicited a slow depolarization (8.2 + 0.5 mV, n = 59) in 95% of the cells tested, accompanied by an increase in excitability. In (68%) of DVMs the depolarization was associated with an increase in apparent membrane resistance (Rm, 22.7+2.2%). These depolarizations and increases in Rm (14.3+2.6%, n=8) were maintained in a medium which blocked synaptic transmission. LY 53,857 (1 gM) and the 5-HTIA/2A receptor antagonist, spiperone (1 jgM). The 5-HTIA receptor antagonist, pindobind 5-HTlA (5 gM), had no effect on the depolarizing response to 5-HT.4 The effect of 5-HT was mimicked by the 5-HT2A,2c receptor agonist, a-methyl-5-HT (50 uM), the 5-HT, receptor agonist, 5-carboxamidotryptamine (20 jIM) and the putative 5-HT4 agonist, 5-methyoxytryptamine (50 pM). The selective 5-HT4 receptor antagonist, GRI13808, had no effect on the depolarizing effect of 5-HT or 5-MEOT on DVMs.

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Afferent projections to the dorsal motor nucleus of the vagus

Cited by 112 publications

References 40 publications

Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat

Descending pathways from hypothalamus to dorsal motor vagus and ambiguus nuclei in the rat

Effects of vasopressin and angiotensin II on neurones in the rat dorsal motor nucleus of the vagus, in vitro.

The effect of 5‐HT and selective 5‐HT receptor agonists and antagonists on rat dorsal vagal preganglionic neurones in vitro

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