Afferent pain pathways: a neuroanatomical review

Almeida, Tatiana Ferrante de; Roizenblatt, Suely; Tufik, Sérgio

doi:10.1016/j.brainres.2003.10.073

Cited by 315 publications

(227 citation statements)

References 109 publications

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“…The fact that no statistically significant group differences in tactile threshold were revealed in the present study seems to contrast with the previously found impairment in tactile finger discrimination, tactual perception of letters traced on the palm, and tactual object recognition in children with DS (Brandt, 1996). However, such functions of proprioception and discriminative touch are mediated by the dorsal column instead of the spinothalamic pathway (Almeida et al, 2004;Fitzgerald et al, 2007).…”

Section: Discussioncontrasting

confidence: 98%

“…Adequate pain management requires a better understanding of how individuals with DS experience pain. This could be supported by insight into the functioning of the somatosensory system, which transmits somatosensory information from peripheral receptors via the spinal cord and brain stem primarily to the thalamus and somatosensory cortex (Almeida, Roizenblatt, & Tufik, 2004;Kaas, Jain, & Qi, 2002). The somatosensory cortex plays a major role in the processing of pain (Kanda et al, 2000).…”

mentioning

confidence: 99%

“…The somatosensory cortex plays a major role in the processing of pain (Kanda et al, 2000). Spinothalamic-mediated sensory functions are the abilities to detect sensations of pain, temperature (innocuous and noxious), and crude touch (Almeida et al, 2004;Fitzgerald, Gruener, & Mtui, 2007).…”

mentioning

confidence: 99%

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Quantitative sensory testing of temperature, pain, and touch in adults with Down syndrome

Knegt

Defrin

Schuengel

et al. 2015

Research in Developmental Disabilities

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A B S T R A C TThe spinothalamic pathway mediates sensations of temperature, pain, and touch. These functions seem impaired in children with Down syndrome (DS), but have not been extensively examined in adults. The objective of the present study was to compare the spinothalamic-mediated sensory functions between adults with DS and adults from the general population and to examine in the DS group the relationship between the sensory functions and level of intellectual functioning. Quantitative sensory testing (QST) was performed in 188 adults with DS (mean age 37.5 years) and 142 age-matched control participants (median age 40.5 years). Temperature, pain, and touch were evaluated with tests for cold-warm discrimination, sharp-dull discrimination (pinprick), and tactile threshold, respectively. Level of intellectual functioning was estimated with the Social Functioning Scale for Intellectual Disability (intellectual disability level) and the Wechsler Preschool and Primary Scale of Intelligence -Revised (intelligence level). Overall, the difference in spinothalamic-mediated sensory functions between the DS and control groups was not statistically significant. However, DS participants with a lower intelligence level had a statistically significant lower performance on the sharp-dull discrimination test than DS participants with higher intelligence level (adjusted p = .006) and control participants (adjusted p = .017). It was concluded that intellectual functioning level is an important factor to take into account for the assessment of spinothalamic-mediated sensory functioning in adults with DS: a lower level could coincide with impaired sensory functioning, but could also hamper QST assessment. ß

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Section: Discussioncontrasting

confidence: 98%

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confidence: 99%

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Quantitative sensory testing of temperature, pain, and touch in adults with Down syndrome

Knegt

Defrin

Schuengel

et al. 2015

Research in Developmental Disabilities

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“…The peripheral elements of nociception, including smalldiameter primary afferent myelinated A␦ and unmyelinated C fibres, enter the spinal cord through the dorsal root and terminate in laminae I and V [Almeida et al, 2004]. Projections from cells with nociceptive input in the dorsal horn ascend in the contralateral spinothalamic tract.…”

Section: Discussionmentioning

confidence: 99%

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Farrell

Laird

Egan

2005

Human Brain Mapping

114

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Abstract:The capacity of pain to alert against potential injury or focus attention on damaged tissue is enhanced by the intrinsically aversive nature of the experience. Finding methods to relieve pain will ultimately be facilitated by deeper understanding of the processes that contribute to the experience, and functional brain imaging has contributed substantially toward that end. An impressive body of literature has identified a distributed network of pain-related activity in the brain that is subject to considerable modulation by different stimulus parameters, contextual factors, and clinical conditions. The fundamental substrates of the pain network are yet to be distilled from the highly variable results of studies published thus far. Qualitative reviews of the pain-imaging literature have been contributory, but lack the greater surety of quantitative methods. We employ the activation likelihood estimation (ALE) meta-analytic technique to establish the most consistent activations among studies reporting brain responses subsequent to the application of noxious heat. A network of pain-related activity was replicated for stimuli to either upper limb that included two discernible regions of the mid-anterior cingulate cortex, bilateral thalami, insula, and opercula cortices, posterior parietal cortex, premotor cortex, supplementary motor area, and cerebellum. The findings of the meta-analysis resonate with other streams of information that continue to enhance our understanding of pain in the brain. The results also point toward new areas of research that may be fruitful for the exploration of central pain processing. Hum Brain Mapp 25:129 -139, 2005.

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“…Todas estas estruturas possuem inervações diretas para a CPME (ALMEIDA; ROINZENBLATT;TUFIK, 2004;BRAZ;ENQUIST;BASBAUM, 2009;HEINRICHER, 2006;MASON, 2001;MILLAN, 1999;ROSENFELD, 1994;SANDKUHLER, 1996). O núcleo dorsal da rafe (NDR) tem sido incluído neste grupo por agir relevantemente na modulação nociceptiva (WANG; NAKAI, 1994), modulação esta que é provavelmente mediada através da sua conexão direta com o NMR ou indireta com a CPME ou com o tálamo (PALAZZO et al, 2006) …”

Section: Modulação Do Estímulo Doloroso (Via De Analgesia Descendente)unclassified

Estimulação do córtex motor e antinocicepção: envolvimento da via de analgesia serotonérgica descendente.

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Afferent pain pathways: a neuroanatomical review

Cited by 315 publications

References 109 publications

Quantitative sensory testing of temperature, pain, and touch in adults with Down syndrome

Quantitative sensory testing of temperature, pain, and touch in adults with Down syndrome

Brain activity associated with painfully hot stimuli applied to the upper limb: A meta‐analysis

Estimulação do córtex motor e antinocicepção: envolvimento da via de analgesia serotonérgica descendente.

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