Afferent influences on brain stem auditory nuclei of the chicken: Time course and specificity of dendritic atrophy following deafferentation

Deitch, Jeffrey S.; Rubel, Edwin W.

doi:10.1002/cne.902290106

Cited by 160 publications

(109 citation statements)

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“…Decreases in the average density of MAP2 immunoreactivity may be partially due to the retraction of deafferented NL dendrites, which occurs as early as 1 hour following XDCT transection (Deitch and Rubel, 1984). Whether cochlea removal produces similar retraction of deafferented NL dendrites has not been studied within the survival time period examined in the current report.…”

Section: Discussionmentioning

confidence: 88%

“…Dendritic MAP2 of NL neurons may be regulated to a varying degree, or by different mechanisms along the rostrocaudal axis. Further examination of MAP2 expression at an individual cell level may be necessary.Decreases in the average density of MAP2 immunoreactivity may be partially due to the retraction of deafferented NL dendrites, which occurs as early as 1 hour following XDCT transection (Deitch and Rubel, 1984). Whether cochlea removal produces similar retraction of deafferented NL dendrites has not been studied within the survival time period examined in the current report.…”

mentioning

confidence: 88%

“…This nucleus is thought to be analogous to the medial superior olivary nucleus of mammals (Burger and Rubel, 2007). NL provides a useful model for studying afferent regulation of dendritic structure and molecular mechanisms underlying this regulation (Deitch and Rubel, 1984;Sorensen and Rubel, 2006). In chicks, differential innervation of the segregated dendritic domains of NL allows local manipulation of the excitatory inputs to one dendritic domain, while leaving the other dendritic domain of the same cells intact to serve as a control.…”

Section: Nih Public Accessmentioning

confidence: 99%

mentioning

confidence: 92%

“…Consequently, excitatory inputs to one set of NL dendrites can easily be silenced or altered by manipulating the ipsilateral or contralateral projection of NM neurons. Previous studies have demonstrated a rapid retraction of the ventral NL dendrites within hours after transection of the contralateral NM projection, while the dorsal NL dendrites, receiving intact input, appear largely unaffected (Benes et al, 1977;Deitch and Rubel, 1984;Sorensen and Rubel, 2006).Little is known regarding the role of synaptic input on the cytoskeletal structure of NL dendrites and whether changes in the cytoskeleton are responsible for deafferentation-induced dendritic retraction. High-molecular weight MAP2s (HMWMAP2), including MAP2A and MAP2B, are of particular interest because of their direct association with microtubules in dendrites and perikarya, as well as colocalization with actin in dendritic spines and postsynaptic densities (see review, Sánchez et al, 2000).…”

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Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity

Wang

Rubel

2008

Neuroscience

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Differential innervation of segregated dendritic domains in the chick nucleus laminaris (NL), composed of third-order auditory neurons, provides a unique model to study synaptic regulation of dendritic structure. Altering the synaptic input to one dendritic domain affects the structure and length of the manipulated dendrites while leaving the other set of unmanipulated dendrites largely unchanged. Little is known about the effects of neuronal input on the cytoskeletal structure of NL dendrites and whether changes in the cytoskeleton are responsible for dendritic remodeling following manipulations of synaptic inputs. In this study, we investigate changes in the immunoreactivity of high-molecular weight microtubule associated protein 2 (MAP2) in NL dendrites following two different manipulations of their afferent input. Unilateral cochlea removal eliminates excitatory synaptic input to the ventral dendrites of the contralateral NL and the dorsal dendrites of the ipsilateral NL. This manipulation produced a dramatic decrease in MAP2 immunoreactivity in the deafferented dendrites. This decrease was detected as early as three hours following the surgery, well before any degeneration of afferent axons. A similar decrease in MAP2 immunoreactivity in deafferented NL dendrites was detected following a midline transection that silences the excitatory synaptic input to the ventral dendrites on both sides of the brain. These changes were most distinct in the caudal portion of the nucleus where individual deafferented dendritic branches contained less immunoreactivity than intact dendrites. Our results suggest that the cytoskeletal protein MAP2, which is distributed in dendrites, perikarya, and postsynaptic densities, may play a role in deafferentation-induced dendritic remodeling. Keywordsdeafferentation; dendritic plasticity; afferent regulation; cytoskeleton Microtubules are a major cytoskeletal component of neuronal dendritic structure. It is well established that microtubule associated protein 2 (MAP2) binding increases the stability of the microtubule network and dendritic structure (Serrano et al., 1984;Kowalski and Williams, 1993;Yamauchi et al., 1993;Sánchez et al., 2000;Harada et al., 2002). MAP2 has been proposed to play a fundamental role as a regulator of dendritic morphology in the developing Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. and adult brain. This idea is supported by dynamic regulation of MAP2 expression and its involvement in dynamic changes in neuronal morphology caused by excitotoxins (Siman and Noszek, 1988;Bigot et al., 1991;Felipo et al., 199...

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Section: Discussionmentioning

confidence: 88%

mentioning

confidence: 88%

Section: Nih Public Accessmentioning

confidence: 99%

mentioning

confidence: 92%

mentioning

confidence: 99%

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Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity

Wang

Rubel

2008

Neuroscience

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Development of the time coding pathways in the auditory brainstem of the barn owl

Carr

Boudreau

1996

J. Comp. Neurol.

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The barn owl's head grows after hatching, causing interaural distances to more than double in the first 3 weeks posthatch. These changes expose the bird to a constantly increasing range of interaural time cues. We have used Golgi and ultrastructural techniques to analyze the development of the connections and cell types of the nucleus magnocellularis (NM) and the nucleus laminaris (NL) with reference to the growth of the head. The time coding circuit is formed but immature at the time of hatching. In the month posthatch, the auditory nerve projection to the NM matures, and appears adult-like by posthatch day (P)21. NM neurons show a late growth of permanent dendrites starting at P6. Over the first month, these dendrites change in length and number, depending upon rostrocaudal position, to establish the adult pattern in which high best frequency neurons have few or no dendrites. These changes are not complete by P21, when NM neurons still have more dendrites than in the adult owl. The neurons of NL have many short dendrites before hatching. Their number is greatly reduced by P6, and then does not change during later development. Like NM neurons, NL neurons and dendrites grow in the first month posthatch, and at P21, NL dendrites are longer than those in the adult owl. Thus, the auditory brainstem circuits grow in the first month after hatching, but are not yet mature at the time the head reaches its adult size.

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Early prenatal critical period for chorda tympani nerve terminal field development

Krimm

Hill

1997

J. Comp. Neurol.

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In order to determine whether the developing central gustatory system responds to dietary manipulation during restricted developmental periods, terminal fields of the chorda tympani nerve within the nucleus of the solitary tract were investigated via anterograde transport of horseradish peroxidase in control rats and in rats in which a low sodium diet was systematically fed during specific periods of development. Rats fed a low sodium diet (0.03% NaCl) from embryonic day 3 (E3) to day E12 and then fed a sodium replete diet to at least 60 days postnatal exhibited enlarged and irregularly shaped chorda tympani terminal fields. Specifically, the dorsal zone of the field was the smallest in controls, whereas it was the largest in restricted rats, occupying more territory within the nucleus. This alteration in the terminal field was apparent in all groups of rats fed the low-NaCl diet beginning at E3, and continuing beyond E12. In contrast, no effects of the dietary manipulation on the developing chorda tympani field was evident when it occurred from E3 to day E9, from E0 to day E9 or when it occurred at adulthood only. Therefore, only 9 days of maternal exposure to a sodium-restricted diet is required for a permanent expansion of the chorda tympani terminal field in the offspring. Moreover, a brief period from E9 to E12 must be included within the 9-day dietary restriction to yield the expanded field. Since this period is before taste receptors appear on the tongue, it is likely that nonactivity-dependent factors determine the formation of the chorda tympani terminal field during later development.

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Afferent influences on brain stem auditory nuclei of the chicken: Time course and specificity of dendritic atrophy following deafferentation

Cited by 160 publications

References 43 publications

Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity

Rapid regulation of microtubule-associated protein 2 in dendrites of nucleus laminaris of the chick following deprivation of afferent activity

Development of the time coding pathways in the auditory brainstem of the barn owl

Early prenatal critical period for chorda tympani nerve terminal field development

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