Afferent connections of gudden's tegmental nuclei in the rabbit

Hayakawa, Tetsu; Zyo, Katuya

doi:10.1002/cne.902350203

Cited by 43 publications

(22 citation statements)

References 41 publications

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“…1990), the superior colliculus (Stechison et al 1985), the pretectal nucleus, and the interstitial nucleus of Cajal by way of the fasciculus longitudinalis medialis (McCrea and Baker 1985). They also send fibers to the fasciculus longitudinalis dorsalis and terminate in the dorsal tegmental nucleus (Hayakawa and Zyo 1985). A few distinct labeled fibers and terminals were observed in the dorsal part of the SUM when PHA-L was injected into the C3 region in the present study.…”

Section: Discussionmentioning

confidence: 51%

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

1993

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We examined the regions projecting to the supramammillary nucleus of the rat with retrograde transport of WGA-HRP and WGA, and anterograde transport of Phaseolus vulgaris leucoagglutinin. The supramammillary nucleus receives major descending afferents from the infralimbic cortex, the dorsal peduncular cortex, the nucleus of the diagonal band of Broca, the medial and lateral preoptic nuclei, bilaterally. The major ascending afferents come from the pars compacta of the nucleus centralis superior, the ventral tegmental nucleus, and the laterodorsal tegmental nucleus. The supramammillary nucleus also receives a few (but distinct) fibers from the anterior and lateral hypothalamic nuclei, the ventral premammillary nucleus, the interpeduncular nucleus, the cuneiform nucleus, the dorsal raphe nucleus, the incertus nucleus, and the C3 region including the prepositus hypoglossi nucleus. All descending fibers run through the medial forebrain bundle. Almost all ascending fibers from the pars compacta of the nucleus centralis superior and the laterodorsal tegmental nucleus run through the mammillary peduncle, and terminate throughout the supramammillary nucleus. A few fibers from the laterodorsal tegmental nucleus and the C3 region run through the fasciculus longitudinalis dorsalis and terminate in the dorsal part of the supramammillary nucleus including the supramammillary decussation.

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Section: Discussionmentioning

confidence: 51%

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

1993

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“…Although it is possible that IPN lesions may have disrupted any one of these processes, we suggest that the structure is at least involved in conveying motor related signals to HD cell circuitry (Sharp et al, 2006), likely through its reciprocal relationship with the DTN and its connections with the lateral habenula, which also projects to the DTN (Fig. 1) (Contestabile & Flumerfelt, 1981; Liu et al, 1984; Groenewegen et al, 1986; Hayakawa & Zho, 1985). Lateral habenula neurons are sensitive to running speed and angular head velocity (Sharp et al, 2006), suggesting that information about self-movements is also generated in this structure.…”

Section: Discussionmentioning

confidence: 89%

Head Direction Cell Instability in the Anterior Dorsal Thalamus after Lesions of the Interpeduncular Nucleus

Clark¹,

Sarma²,

Taube³

2009

J. Neurosci.

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Previous research has identified a population of cells throughout the limbic system that discharge as a function of the animal's head direction (HD). Altering normal motor cues can alter the HD cell responses and disrupt the updating of their preferred firing directions, thus suggesting that motor cues contribute to processing the HD signal. A pathway that conveys motor information may stem from the interpeduncular nucleus (IPN), a brain region that has reciprocal connections with HD cell circuitry. To test this hypothesis, we produced electrolytic or neurotoxic lesions of the IPN and recorded HD cells in the anterior dorsal thalamus (ADN) of rats. Direction-specific firing remained present in the ADN after lesions of the IPN, but measures of HD cell properties showed that cells had reduced peak firing rates, large directional firing ranges, and firing that predicted the animal's future heading more than in intact controls. Furthermore, preferred firing directions were moderately less influenced by rotation of a salient visual landmark. Finally, the preferred directions of cells in lesioned rats exhibited large shifts when the animals foraged for scattered food pellets in a darkened environment and when locomoting from a familiar environment to a novel one. We propose that the IPN contributes motor information about the animal's movements to the HD cell circuitry. Furthermore, these results suggest that the IPN plays a broad role in the discharge properties and stability of directionspecific activity in the HD cell circuit.

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“…The DTN receives ascending input from the vestibular pathway including the NPH and SGN (Hayakawa and Zyo, 1985; Liu et al, 1984; Biazoli et al, 2006; Groenewegen and Van Dijk, 1984; McCrea and Baker, 1985). Moreover, the medial vestibular nuclei are interconnected with the NPH (McCrea and Horn, 2006; Horowitz et al, 2005) and also project to the SGN (Biazoli et al, 2006).…”

Section: Vestibular Systemmentioning

confidence: 99%

Resolving the active versus passive conundrum for head direction cells

Shinder

Taube

2014

Neuroscience

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Head direction (HD) cells have been identified in a number of limbic system structures. These cells encode the animal’s perceived directional heading in the horizontal plane and are dependent on an intact vestibular system. Previous studies have reported that the responses of vestibular neuron within the vestibular nuclei are markedly attenuated when an animal makes a volitional head turn compared to passive rotation. This finding presents a conundrum in that if vestibular responses are suppressed during an active head turn how is a vestibular signal propagated forward to drive and update the HD signal? This review identifies and discusses four possible mechanisms that could resolve this problem. These mechanisms are: 1) the ascending vestibular signal is generated by more than just vestibular-only neurons, 2) not all vestibular-only neurons contributing to the HD pathway have firing rates that are attenuated by active head turns, 3) the ascending pathway may be spared from the affects of the attenuation in that the HD system receives information from other vestibular brainstem sites that do not include vestibular-only cells, 4) the ascending signal is affected by the inhibited vestibular signal during an active head turn, but the HD circuit compensates and uses the altered signal to accurately update the current head direction. Future studies will be needed to decipher which of these possibilities is correct.

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Afferent connections of gudden's tegmental nuclei in the rabbit

Cited by 43 publications

References 41 publications

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

Neuroanatomical study of afferent projections to the supramammillary nucleus of the rat

Head Direction Cell Instability in the Anterior Dorsal Thalamus after Lesions of the Interpeduncular Nucleus

Resolving the active versus passive conundrum for head direction cells

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