Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Cádiz-Moretti, Bernardita; Abellán-Álvaro, María; Pardo-Bellver, Cecília; Martínez‐Garciá, Fernando; Lanuza, Enrique

doi:10.3389/fnana.2016.00125

Cited by 27 publications

(30 citation statements)

References 45 publications

(88 reference statements)

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“…Our findings show that the ACo receives substantial projections arising from the olfactory cortex, a hodological feature shared with the CxA, the Me and the PMCo (Gutiérrez‐Castellanos et al, ; Cádiz‐Moretti et al, ,). The ACo also projects back to the olfactory cortex.…”

Section: Discussionsupporting

confidence: 55%

“…The pattern of labeling was similar in all the restricted injections (case #1339 is illustrated in Figure ). In the non‐restricted injections, the resulting labeling included the pattern observed in the restricted ones, as well as labeling due to the CxA (Cádiz‐Moretti et al, ) or the PLCo (Ubeda‐Bañon et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…The ACo receives denser projections from the caudal than from the rostral Pir, a hodological feature also showed by the Me (Cádiz‐Moretti et al, ). In contrast, the CxA shows the opposite pattern, receiving more projections from the rostral Pir (Cádiz‐Moretti et al, ). According to electrophysiological studies, the posterior Pir shows associative encoding characteristics (Calu, Roesch, Stalnaker, & Schoenbaum, ), and thus may act as an associative cortex that sends to the ACo highly processed olfactory information that includes the behavioral significance of the odorant.…”

Section: Discussionmentioning

confidence: 99%

“…The specificity of the anti‐FG antibody has been previously characterized, and this antibody has been extensively used in our laboratory (e.g., Gutiérrez‐Castellanos et al, ; Cádiz‐Moretti et al, ,). The omission of the primary antibody or performing the immunohistochemical procedure in animals with no FG injection yielded no labeling.…”

Section: Methodsmentioning

confidence: 99%

“…This work is part of a long‐term project aiming to provide a complete description of the connectivity of the chemosensory amygdala in mice. We have previously reported the connections of the Me (Pardo‐Bellver, Cádiz‐Moretti, Novejarque, Martínez‐García, & Lanuza, ; Cádiz‐Moretti et al, ), the posteromedial cortical nucleus of the amygdala (Gutiérrez‐Castellanos, Pardo‐Bellver, Martínez‐García, & Lanuza, ) and the cortex–amygdala transition zone (Cádiz‐Moretti, Abellán‐Álvaro, Pardo‐Bellver, Martínez‐García, & Lanuza, ), as well as the connection of the chemosensory amygdaloid structures with the ventral striatum (Ubeda‐Bañon et al, ; Novejarque, Gutiérrez‐Castellanos, Lanuza, & Martínez‐García, ). The aim of this work is to provide a comprehensive description of the afferent and efferent connections of the ACo in mice, which is currently lacking.…”

Section: Introductionmentioning

confidence: 99%

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Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Cádiz-Moretti

Abellán-Álvaro

Pardo-Bellver

et al. 2017

J of Comparative Neurology

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The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, partially due to a lack of knowledge of its connectivity. In this work, we describe the pattern of afferent and efferent projections of the ACo by using fluorogold and biotinylated dextranamines as retrograde and anterograde tracers, respectively. The results show that the ACo is reciprocally connected with the olfactory system and basal forebrain, as well as with the chemosensory and basomedial amygdala. In addition, it receives dense projections from the midline and posterior intralaminar thalamus, and moderate projections from the posterior bed nucleus of the stria terminalis, mesocortical structures and the hippocampal formation. Remarkably, the ACo projects moderately to the central nuclei of the amygdala and anterior bed nucleus of the stria terminalis, and densely to the lateral hypothalamus. Finally, minor connections are present with some midbrain and brainstem structures. The afferent projections of the ACo indicate that this nucleus might play a role in emotional learning involving chemosensory stimuli, such as olfactory fear conditioning. The efferent projections confirm this view and, given its direct output to the medial part of the central amygdala and the hypothalamic 'aggression area', suggest that the ACo can initiate defensive and aggressive responses elicited by olfactory or, to a lesser extent, vomeronasal stimuli.

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Section: Discussionsupporting

confidence: 55%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Cádiz-Moretti

Abellán-Álvaro

Pardo-Bellver

et al. 2017

J of Comparative Neurology

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Brain olfactory‐related atrophy in isolated rapid eye movement sleep behavior disorder

Woo,

Kim,

Yoon

et al. 2023

Ann Clin Transl Neurol

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ObjectiveTo investigate structural and functional connectivity changes in brain olfactory‐related structures in a longitudinal prospective cohort of isolated REM sleep behavior disorder (iRBD) and their clinical correlations, longitudinal evolution, and predictive values for phenoconversion to overt synucleinopathies, especially Lewy body diseases.MethodsThe cohort included polysomnography‐confirmed iRBD patients and controls. Participants underwent baseline assessments including olfactory tests, neuropsychological evaluations, the Movement Disorders Society–Unified Parkinson's Disease Rating Scale, 3T brain MRI, and 18F‐FP‐CIT PET scans. Voxel‐based morphometry (VBM) was performed to identify regions of atrophy in iRBD, and volumes of relevant olfactory‐related regions of interest (ROI) were estimated. Subgroups of patients underwent repeated volumetric MRI and resting‐state functional MRI (fMRI) scans after four years.ResultsA total of 51 iRBD patients were included, with 20 of them converting to synucleinopathy (mean time to conversion 3.08 years). Baseline VBM analysis revealed atrophy in the right olfactory cortex and gyrus rectus in iRBD. Subsequent ROI comparisons with controls showed atrophy in the amygdala. These olfactory‐related atrophies tended to be associated with worse depression, anxiety, and urinary problems in iRBD. Amygdala 18F‐FP‐CIT uptake tended to be reduced in iRBD patients with hyposmia (nonsignificant after multiple comparison correction) and correlated with urinary problems. Resting‐state fMRI of 23 patients and 32 controls revealed multiple clusters with aberrant olfactory‐related functional connectivity. Hypoconnectivity between the putamen and olfactory cortex was associated with mild parkinsonian signs in iRBD. Longitudinal analysis of volumetric volumetric MRI in 22 iRBD patients demonstrated four‐year progression of olfactory‐related atrophy. Cox regression analysis revealed that this atrophy significantly predicted phenoconversion.InterpretationProgressive atrophy of central olfactory structures may be a potential indicator of Lewy body disease progression in iRBD.

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Amygdala subnuclei development in adolescents with autism spectrum disorder: Association with social communication and repetitive behaviors

et al. 2021

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Introduction:The amygdala subnuclei regulate emotional processing and are widely implicated in social cognitive impairments often seen in children with autism spectrum disorder (ASD). Dysregulated amygdala development has been reported in young children with ASD; less is known about amygdala maturation in later adolescence, a sensitive window for social skill development. Methods: The macrostructural development of the amygdala subnuclei was assessed at two time points in a longitudinal magnetic resonance imaging (MRI) study of adolescents with ASD (n = 23) and typically-developing adolescents (n = 15) . In adolescents with ASD, amygdala subnuclei growth was assessed in relation to ASD symptomatology based on standardized diagnostic assessments. Participants were scanned with MRI at median age of 12 years and returned for a second scan at a median age of 15 years. The volumes of nine amygdala subnuclei were extracted using an automatic segmentation algorithm. Results: When examining the longitudinal data acquired across two time points, adolescents with ASD had larger basolateral amygdala (BLA) nuclei volumes compared to typically developing adolescents (B = 46.8, p = 0.04). When examining ASD symptomatology in relation to the growth of the amygdala subnuclei, reciprocal social interaction scores on the ADI-R were positively associated with increased growth of the BLA nuclei (B = 8.3, p < 0.001). Growth in the medial nucleus negatively predicted the communication (B = −46.9, p = 0.02) and social (B = −47.7, p < 0.001) domains on the ADOS-G. Growth in the right cortical nucleus (B = 26.14, p = 0.02) positively predicted ADOS-G social scores. Central nucleus maturation (B = 29.9, p = 0.02) was associated with the repetitive behaviors domain on the ADOS-G.Conclusions: Larger BLA volumes in adolescents with ASD may reflect underlying alterations in cellular density previously reported in post-mortem studies. Furthermore, findings demonstrate an association between regional growth in amygdalaThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice

Cited by 27 publications

References 45 publications

Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse

Brain olfactory‐related atrophy in isolated rapid eye movement sleep behavior disorder

Amygdala subnuclei development in adolescents with autism spectrum disorder: Association with social communication and repetitive behaviors

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