Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat

Cornwall, J.; Cooper, Jonathan D.; Phillipson, O.T.

doi:10.1016/0361-9230(90)90072-8

Cited by 263 publications

(199 citation statements)

References 72 publications

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“…These subnuclei send efferent fibers containing serotonergic REM-off neurons to the MnR and DRN and efferent fibers containing cholinergic REM-on neurons to the LDTg (3,9,11,27). In addition, the IPc and IPl subnuclei send efferent fibers to the NI (8, 9, 11), which relays ascending projections from the nucleus pontis oralis to the medial septal nucleus, a pathway implicated in hippocampal theta generation (14).…”

Section: Discussionmentioning

confidence: 99%

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato

Sato²,

Sinton³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Sleep and wakefulness are regulated primarily by inhibitory interactions between the hypothalamus and brainstem. The expression of the states of rapid eye movement (REM) sleep and non-REM (NREM) sleep also are correlated with the activity of groups of REM-off and REM-on neurons in the dorsal brainstem. However, the contribution of ventral brainstem nuclei to sleep regulation has been little characterized to date. Here we examined sleep and wakefulness in mice deficient in a homeobox transcription factor, Goosecoid-like (Gscl), which is one of the genes deleted in DiGeorge syndrome or 22q11 deletion syndrome. The expression of Gscl is restricted to the interpeduncular nucleus (IP) in the ventral region of the midbrain-hindbrain transition. The IP has reciprocal connections with several cell groups implicated in sleep/wakefulness regulation. Although Gscl −/− mice have apparently normal anatomy and connections of the IP, they exhibited a reduced total time spent in REM sleep and fewer REM sleep episodes. In addition, Gscl −/− mice showed reduced theta power during REM sleep and increased arousability during REM sleep. Gscl −/− mice also lacked the expression of DiGeorge syndrome critical region 14 (Dgcr14) in the IP. These results indicate that the absence of Gscl and Dgcr14 in the IP results in altered regulation of REM sleep.homeobox transcription factor | mouse behavior | ventral brainstem

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Section: Discussionmentioning

confidence: 99%

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Funato

Sato²,

Sinton³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Thus, the midbrain tectum is in a pivotal position to initiate behavioral responses to sensory stimuli. The large projection from the deep layers of the SC to the pedunculopontine tegmentum (PPT) (28) and the projection from the PT to the laterodorsal tegmentum (LDT) (29) are possible candidates for mediation of lights-off stimulation and͞or lights-on suppression of REM sleep generation, because the LDT͞PPT region is known to mediate REM sleep (30,31). Further studies are necessary to determine which projections from the SC-PT to putative sleep-wakefulness regulatory areas mediate the various effects of light-dark transitions on sleep behavior.…”

Section: Discussionmentioning

confidence: 99%

The superior colliculus–pretectum mediates the direct effects of light on sleep

Miller

Obermeyer

Behan

et al. 1998

Proc. Natl. Acad. Sci. U.S.A.

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Light and dark have immediate effects on sleep and wakefulness in mammals, but the neural mechanisms underlying these effects are poorly understood. Lesions of the visual cortex or the superior colliculus-pretectal area were performed in albino rats to determine retinorecipient areas that mediate the effects of light on behavior, including rapid eye movement sleep triggering by lights-off and redistribution of non-rapid eye movement sleep in short light-dark cycles. Acute responses to changes in light conditions were virtually eliminated by superior colliculus-pretectal area lesions but not by visual cortex lesions. Circadian entrainment was evident in both groups with lesions and in normal controls. Thus, acute light-dark effects on sleep and wakefulness appear to be mediated independently from cortical vision or circadian rhythms.

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“…These transection-specific effects suggested that the mamillothalamic tract is involved specifically in avoidance-relevant processing of the CS + Other findings suggested that the system of cholinergic fibers which originate in the lateral dorsal tegmental (LDT) nucleus (Hoover and Baisden, 1980;Satoh and Fibiger, 1986;Woolf and Butcher, 1986;Hallanger et al, 1987;Cornwall et al, 1990;Shibata, 1992;Poremba et al, 1994) is also involved in the mediation of training-induced activity. However, this system appears to be involved only in the production of excitatory training-induced activity in the AV nucleus, as suggested by the finding that blockade of muscarinic receptors by systemic and local intracranial administration of scopolamine hydrobromide eliminated the excitatory CS-elicited activity of AV thalamic and posterior cingulate cortical neurons in trained rabbits (Henzi et al, 1990;Kubota et al, 1993) but did not affect discriminative training-induced activity.…”

Section: Discussionmentioning

confidence: 99%

Mamillothalamic tract transection blocks anterior thalamic training- induced neuronal plasticity and impairs discriminative offidance behavior in rabbits

et al. 1995

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Rabbits with bilateral transecting lesions of the mamillothalamic tract, control (tract-sparing and sham) lesions, or no lesions, and chronic, fixed-position anterior ventral (AV) and medial dorsal (MD) thalamic and posterodorsal subicular complex unit recording electrodes were trained to step in an activity wheel in response to a 0.5 sec tone (CS+) in order to avoid a brief foot shock. The rabbits also learned to ignore a different tone (CS-) not predictive of shock. Behavioral acquisition was significantly retarded in rabbits with mamillothalamic tract transection compared to controls. When trained, transected rabbits failed to avoid the shock more often than controls. Mamillothalamic tract transection abolished and control lesions attenuated AV thalamic discriminative training-induced activity (i.e., development with training of greater discharges in response to the CS+ than to the CS-). Transection and control lesions attenuated AV thalamic excitatory training-induced activity (greater elicited activity during training than during unpaired tone-shock presentations before training) as well as AV thalamic “spontaneous” baseline unit activity. CS-elicited discharge magnitude was reduced by control lesions and it was further reduced by tract transecting lesions. Significant lesion-related changes were not found in the subicular or MD thalamic neuronal receptor. Mamillothalamic tract afferent information flow is thus essential for AV thalamic discriminative training-induced activity, excitatory training-induced activity, tone- elicited discharges and maintenance of conditioned avoidance responses. The effects of the control lesions suggested that afferents which course in parallel with and near the mamillothalamic tract may contribute to AV thalamic spontaneous activity and excitatory training- induced activity.

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Afferent and efferent connections of the laterodorsal tegmental nucleus in the rat

Cited by 263 publications

References 72 publications

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep

The superior colliculus–pretectum mediates the direct effects of light on sleep

Mamillothalamic tract transection blocks anterior thalamic training- induced neuronal plasticity and impairs discriminative offidance behavior in rabbits

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