Affective temperaments and their relationships with life events in bipolar patients and siblings: a controlled study

Saguem, Bochra Nourhène; Mtiraoui, Abderraouf; Nakhli, Jaâfar; Mannai, J.; Salah, N. Ben; Kissi, Y. El; Nasr, S. Ben

doi:10.1080/09638237.2019.1608924

Cited by 5 publications

(6 citation statements)

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“…Earlier data from our group provided support to the relevance of the anxious and depressive temperaments in increasing the likelihood of full-blown anxious and depressive comorbidities in patients with AN [ 36 ] and specific AN psychopathology, even after controlling for current anxiety and depressive symptoms [ 37 ]. These findings mirror those from other fields of psychiatry, including panic disorder [ 40 ], bipolar disorders [ 41 ], and suicide [ 42 ].…”

Section: Introductionsupporting

confidence: 82%

Mediation models of anxiety and depression between temperament and drive for thinness and body dissatisfaction in anorexia nervosa

et al. 2022

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Purpose Anorexia nervosa (AN) is a life-threatening condition in which temperament, anxiety, depression, and core AN body-related psychopathology (drive for thinness, DT, and body dissatisfaction, BD) are intertwined. This relationship has not been to date disentangled; therefore, we performed a multiple mediation analysis aiming to quantify the effect of each component. Methods An innovative multiple mediation statistical method has been applied to data from 184 inpatients with AN completing: Temperament Evaluation of Memphis, Pisa, Paris, and San Diego Autoquestionnaire, Eating Disorders Inventory-2, State-Trait Anxiety Inventory, and Beck Depression Inventory. Results All affective temperaments but the hyperthymic one were involved in the relationship with DT and BD. Only the anxious temperament had a significant unmediated direct effect on DT after the strictest correction for multiple comparisons, while the depressive temperament had a significant direct effect on DT at a less strict significance level. State anxiety was the strongest mediator of the link between affective temperament and core AN body-related psychopathology. Depression showed intermediate results while trait anxiety was not a significant mediator at all. Conclusion Affective temperaments had a relevant impact on body-related core components of AN; however, a clear direct effect could be identified only for the anxious and depressive temperaments. Also, state anxiety was the strongest mediator thus entailing interesting implications in clinical practice. Level of evidence V, cross-sectional study.

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Section: Introductionsupporting

confidence: 82%

Mediation models of anxiety and depression between temperament and drive for thinness and body dissatisfaction in anorexia nervosa

et al. 2022

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“…An increasing number of life events seem to be associated with increasing levels of affective symptoms -and specifically that depressive symptoms and negative life events both precede each other. 35 Along this line, a recent study found that the number of reported life events was associated with anxious and cyclothymic temperament, 36 which implies that life events and affective symptoms should be viewed in the context of one another and have an effect in both directions.…”

Section: Discussionmentioning

confidence: 99%

Association between lifetime and recent stressful life events and the early course and psychopathology in patients with newly diagnosed bipolar disorder, first‐degree unaffected relatives and healthy controls: Cross‐sectional results from a prospective study

et al. 2021

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Objective: There is an accumulation of stressful life events prior to the first mood episode, but the impact of previous severe life events on psychopathology in patients with bipolar disorder (BD) is not well studied. We aimed to examine the number of recent and lifetime life events in patients with newly diagnosed BD, their unaffected relatives (UR), and healthy controls (HC) as well as the impact of severe lifetime life events on the early course of BD. Methods:We compared the number of recent and lifetime life events in 398 patients with newly diagnosed BD, 109 UR, and 214 HC. We subsequently dichotomized the patients with BD by >2 lifetime life events to investigate the associations of severe lifetime life events with clinical characteristics and affective symptoms.Results: Patients with newly diagnosed BD reported significantly more life events in the last 12 months and lifetime before compared with UR and HC. Patients who reported >2 lifetime life events (n = 160) compared with patients with 0-2 life events (n = 238) had a significantly longer diagnostic delay (9.5 years ± 8.2 vs. 6.2 years ± 6.9), presented with more anxiety and depressive symptoms and had at least one previous suicide attempt (30.6% vs. 15.6%) and one previous admission (51.3% vs. 36.6%). Conclusion:The experience of severe lifetime life events seems to impact the early course in BD in terms of longer diagnostic delay, more severe psychopathology including more admissions and a more than doubled risk for previous suicide attempts.

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“…Finally, we could not demonstrate any role for HT in predicting any bipolar diagnosis, at the multivariate level. When HT scores were considered as continuous scores, we initially found HT to be a predictor of bipolarity when all bipolarity patients were grouped together and also in different bipolar subtypes, a finding similar to some studies [8, 16]. However, as we highlighted above in the section “Results,” when we looked closer at this, we found that the predictive role of HT was limited only to the normal ranges of 0–1 SD above the mean.…”

Section: Discussionmentioning

confidence: 99%

“…The CT, as measured by the TEMPS-A, like all temperaments is a lifelong trait characterized by frequent and rapid shifts between high and low moods and cognitive psychomotor perspectives, as well as instability in relationships. The relation of CT to bipolar disorders has been repeatedly demonstrated in several studies: patients with bipolar I and II had significantly higher scores on the TEMPS-A CT subscale compared to patients with major depressive disorder (MDD) [ 6 – 13 ] and crucially also to healthy controls [ 8 , 14 – 18 ].…”

Section: Introductionmentioning

confidence: 99%

“…The IT was delineated mostly through negative traits, as having a restless mood, feeling on edge, with angry outbursts and a tendency to ill-humored joking [ 21 ]. With the exception of one study [ 32 ], several publications found that patients with bipolarity have elevated IT scores compared to patients with depression and, also interestingly, to healthy controls [ 8 , 9 , 12 – 16 , 26 , 33 , 34 ]. However, a common tacit assumption throughout the literature has been that CT and HT played the real and “logical” role rather than IT [ 6 , 21 , 35 , 36 ].…”

Section: Introductionmentioning

confidence: 99%

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The role of affective temperaments in bipolar disorder: The solid role of the cyclothymic, the contentious role of the hyperthymic, and the neglected role of the irritable temperaments

et al. 2023

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Affective temperaments and their relationships with life events in bipolar patients and siblings: a controlled study

Cited by 5 publications

References 36 publications

Mediation models of anxiety and depression between temperament and drive for thinness and body dissatisfaction in anorexia nervosa

Mediation models of anxiety and depression between temperament and drive for thinness and body dissatisfaction in anorexia nervosa

Association between lifetime and recent stressful life events and the early course and psychopathology in patients with newly diagnosed bipolar disorder, first‐degree unaffected relatives and healthy controls: Cross‐sectional results from a prospective study

The role of affective temperaments in bipolar disorder: The solid role of the cyclothymic, the contentious role of the hyperthymic, and the neglected role of the irritable temperaments

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