Affective Symptoms and White Matter Changes in Brain Tumor Patients

Richter, André; Woernle, Christoph M.; Krayenbühl, Niklaus; Kollias, Spyridon; Bellut, David

doi:10.1016/j.wneu.2015.05.031

Cited by 16 publications

(10 citation statements)

References 30 publications

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“… 1 (McDaniel et al 1995) 2 (Massie 2004) 3 (Krebber et al 2014) 4 (Richter et al 2015) 5 (Hartung et al 2017) 6 (Thekdi et al 2015) 7 (Kasparian 2013) 8 (Watts et al 2014)…”

Section: Kynurenine Pathway In Cancermentioning

confidence: 99%

Inflammation in cancer and depression: a starring role for the kynurenine pathway

et al. 2019

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Depression is a common comorbidity in cancer cases, but this is not only due to the emotional distress of having a life-threatening disease. A common biological mechanism, involving a dysregulated immune system, seems to underpin this comorbidity. In particular, the activation of the kynurenine pathway of tryptophan degradation due to inflammation may play a key role in the development and persistence of both diseases. As a consequence, targeting enzymes involved in this pathway offers a unique opportunity to develop new strategies to treat cancer and depression at once. In this work, we provide a systematic review of the evidence up to date on the kynurenine pathway role in linking depression and cancer and on clinical implications of this evidence. In particular, complications due to chemotherapy are discussed, as well as the potential antidepressant efficacy of novel immunotherapies for cancer.Electronic supplementary materialThe online version of this article (10.1007/s00213-019-05200-8) contains supplementary material, which is available to authorized users.

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“… 1 (McDaniel et al 1995) 2 (Massie 2004) 3 (Krebber et al 2014) 4 (Richter et al 2015) 5 (Hartung et al 2017) 6 (Thekdi et al 2015) 7 (Kasparian 2013) 8 (Watts et al 2014)…”

Section: Kynurenine Pathway In Cancermentioning

confidence: 99%

Inflammation in cancer and depression: a starring role for the kynurenine pathway

et al. 2019

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“…4) comprises terms related to psychological factors in brain tumour patients (e.g. "fatigue", "anxiety" or "depression") and their influence on QoL [35][36][37][38]. Diagnosis and treatment of a brain tumour usually entail a Fig.…”

Section: Discussionmentioning

confidence: 99%

Research on cognitive and sociocognitive functions in patients with brain tumours: a bibliometric analysis and visualization of the scientific landscape

et al. 2020

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Background Many patients with brain tumours exhibit mild to severe (neuro)cognitive impairments at some point during the course of the disease. Social cognition, as an instance of higher-order cognitive functioning, specifically enables initiation and maintenance of appropriate social interactions. For individuals being confronted with the diagnosis of a brain tumour, impairment of social function represents an additional burden, since those patients deeply depend on support and empathy provided by family, friends and caregivers. Methods The present study explores the scientific landscape on (socio)cognitive functioning in brain tumour patients by conducting a comprehensive bibliometric analysis using VOSviewer. The Web of Science Core Collection database was examined to identify relevant documents published between 1945 and 2019. Results A total of 664 English titles on (socio)cognitive functions in patients with brain tumours was retrieved. Automated textual analysis revealed that the data available so far focus on three major topics in brain tumour patients: cognitive functions in general and in paediatric cases, as well as psychological factors and their influence on quality of life. The focus of research has gradually moved from clinical studies with cognitive functions as one of the outcome measures to investigations of interactions between cognitive functions and psychological constructs such as anxiety, depression or fatigue. Medical, neurological and neuropsychological journals, in particular neuro-oncological journals published most of the relevant articles authored by a relatively small network of well interconnected researchers in the field. Conclusion The bibliometric analysis highlights the necessity of more research on social cognition in brain tumour patients.

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“…Specifically, the unique feature of this study is that it will overcome previous shortcomings by examining, in a comprehensive way, the patients’ characteristics together with the caregivers’ quality of life and mental health. With respect to patients’ psychological deficits, previous studies have mainly focused on the effect of gliomas (location, treatments, grade) on cognitive alterations (executive, attention, memory 14 15 ) and affective disorders such as anxiety, depression or emotional awareness 53 54 . However, despite the direct consequences of the tumour on the functional, cognitive and affective deficits of patients, tumours may also lead to social deficits, which have rarely been examined to date.…”

Section: Discussionmentioning

confidence: 99%

Caregivers’ quality of life and psychological health in response to functional, cognitive, neuropsychiatric and social deficits of patients with brain tumour: protocol for a cross-sectional study

et al. 2017

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IntroductionPatients with gliomas generally present cognitive, neuropsychiatric and functional deficits. Although previous research has shown that their caregivers present a poor quality of life and poor mental health, only a few studies have tested in a comprehensive way which deficits/preserved abilities of patients predominantly impact their caregivers. Furthermore, only a few studies have focused on the social impact of gliomas, which may also damage the caregivers’ quality of life. Therefore, this cross-sectional study aims to investigate which patients’ impairments are particularly deleterious for the caregivers and whether the histological characteristics of the gliomas also affect their quality of life.Methods and analysisIn order to examine these research questions, this study intends to include 180 patients (60 patients with grade II gliomas, 60 patients with grade III gliomas and 60 patients with grade IV gliomas), their caregivers and 60 healthy controls. While patients will complete a full battery of cognitive, neuropsychiatric, functional and social tests, caregivers will complete questionnaires about their quality of life, depression, anxiety and burden. Patients’ performances and caregivers’ reports of depression and anxiety will be compared with the scores of healthy controls. Eventually, our aim will be to provide specific care support both to reduce patients’ deficits and alleviate caregivers’ difficulties.Ethics and disseminationThe study has obtained the approval of the local faculty ethics committee (‘Comité d’éthique en sciences comportementales’; 2016–5 S41 and 2015–3 S37). On completion of the study, data will be kept by Lille University for 5 years before they are destroyed. Study findings will be disseminated through peer-reviewed journal publications and conference presentations with no reference to a specific individual.

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Affective Symptoms and White Matter Changes in Brain Tumor Patients

Cited by 16 publications

References 30 publications

Inflammation in cancer and depression: a starring role for the kynurenine pathway

Inflammation in cancer and depression: a starring role for the kynurenine pathway

Research on cognitive and sociocognitive functions in patients with brain tumours: a bibliometric analysis and visualization of the scientific landscape

Caregivers’ quality of life and psychological health in response to functional, cognitive, neuropsychiatric and social deficits of patients with brain tumour: protocol for a cross-sectional study

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