Affective prosody perception in symptomatically remitted patients with schizophrenia and bipolar disorder

Hoertnagl, Christine M.; Yalcin-Siedentopf, Nursen; Baumgartner, Susanne E.; Biedermann, Falko; Deisenhammer, E; Hausmann, Armand; Kaufmann, Alexandra; Kemmler, Georg; Mühlbacher, Moritz; Rauch, Anna-Sophia; Fleischhacker, W. Wolfgang; Hofer, Alex

doi:10.1016/j.schres.2014.07.019

Cited by 19 publications

(19 citation statements)

References 21 publications

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“…There is a growing amount of evidence showing schizophrenic patients’ impairments in social cognition, which can be regarded as a powerful predictor of patients’ impaired social functioning [ 7 , 10 ]. Some researchers further identified comparable social cognition disorders between schizophrenic patients and patients with other psychotic disorders such as bipolar disorder [ 11 ], and highlighted the importance of continuous psychosocial support and social cognition analysis techniques and training programs [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

“…Emotional prosody processing (EPP) refers to the perception and production of EP, the study of which can contribute to the clinical diagnosis and treatment as well as in-depth research on participants’ processing of both linguistic and non-linguistic information in communication. The EPP performance of patients with psychotic disorders have been a focal point in recent years’ research, involving people suffering from schizophrenia, borderline personality disorder, autism spectrum disorder, bipolar disorder, depression, and schizoaffective disorder [ 11 , 16 , 17 , 18 , 19 ]. In these studies, affect perception ability was shown to have an association with social functioning and play an increasingly important role in interpersonal relations.…”

Section: Introductionmentioning

confidence: 99%

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Emotional Prosody Processing in Schizophrenic Patients: A Selective Review and Meta-Analysis

Lin

Ding

Zhang

2018

JCM

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Emotional prosody (EP) has been increasingly recognized as an important area of schizophrenic patients’ dysfunctions in their language use and social communication. The present review aims to provide an updated synopsis on emotional prosody processing (EPP) in schizophrenic disorders, with a specific focus on performance characteristics, the influential factors and underlying neural mechanisms. A literature search up to 2018 was conducted with online databases, and final selections were limited to empirical studies which investigated the prosodic processing of at least one of the six basic emotions in patients with a clear diagnosis of schizophrenia without co-morbid diseases. A narrative synthesis was performed, covering the range of research topics, task paradigms, stimulus presentation, study populations and statistical power with a quantitative meta-analytic approach in Comprehensive Meta-Analysis Version 2.0. Study outcomes indicated that schizophrenic patients’ EPP deficits were consistently observed across studies (d = −0.92, 95% CI = −1.06 < δ < −0.78), with identification tasks (d = −0.95, 95% CI = −1.11 < δ < −0.80) being more difficult to process than discrimination tasks (d = −0.74, 95% CI = −1.03 < δ < −0.44) and emotional stimuli being more difficult than neutral stimuli. Patients’ performance was influenced by both participant- and experiment-related factors. Their social cognitive deficits in EP could be further explained by right-lateralized impairments and abnormalities in primary auditory cortex, medial prefrontal cortex and auditory-insula connectivity. The data pointed to impaired pre-attentive and attentive processes, both of which played important roles in the abnormal EPP in the schizophrenic population. The current selective review and meta-analysis support the clinical advocacy of including EP in early diagnosis and rehabilitation in the general framework of social cognition and neurocognition deficits in schizophrenic disorders. Future cross-sectional and longitudinal studies are further suggested to investigate schizophrenic patients’ perception and production of EP in different languages and cultures, modality forms and neuro-cognitive domains.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Emotional Prosody Processing in Schizophrenic Patients: A Selective Review and Meta-Analysis

Lin

Ding

Zhang

2018

JCM

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“…pitch) abilities contribute to prosodic processing more generally, it also offers a more general proof-of-concept for a new approach to the cognitive neuroscience of neuropsychiatric illnesses.Illnesses like schizophrenia are increasingly appreciated as being heterogeneous innature,and abnormal behavior such as prosody perception may be impaired in some individuals, but not in others. Additionally, many of the socio-cognitive markers such as impaired prosody perception that present in schizophrenia are not specific to the illness, and alsopresent in other disorders such as autism, Alzheimer"s disease, bipolar disorder, and Parkinson"s disease (42)(43)(44)(45)(46). From a neuroscience perspective, the ability to perceive social intent through prosody is a highly complex event involvingmany cortical and subcortical brain regions (47)(48)(49)(50).…”

Section: Discussionmentioning

confidence: 99%

What rhythmic perception and amusia can tell us about vocal social communication in schizophrenia

Rlc

Gamez

Bolgar

et al. 2016

Preprint

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Background: Perceiving social intent throughvocal intonation is impaired in schizophrenia; thisdysprosodia partly arisingfrom impaired pitch perception.Individuals with amusia (tone-deafness) are insensitive to pitch change andalso demonstrate prosody deficits. Sensitivity to rhythm is reduced in amusia when tonal sequences contain pitch changes (polytonic), but is normal for monotonic sequences, suggestingperceptual impairment originates at a secondary processing stage where pitch-and timerelatedcues are yoked.Here, we sought to ascertain: 1) whether schizophreniapatients demonstrate rhythmic deficits, 2) whether suchdeficits are restricted to polytonic sequences, and 3) how pitch and rhythm perception relate to prosodic processing.Methods: Seventy-sixparticipants (33 schizophrenia) completed tasks assessing pitch and prosody perception, as well as monotonic and polytonic rhythmic perception. Results: Increasing tone-deafness correlated with pitch-dependent rhythm detection impairments. Pitch and prosody correlated across all participants. Schizophreniapatients displayed basic time and pitch deficits. Correlations and path analyses indicated prosodic processing is an associatedfunction of pitch and pitch-dependent rhythm perception,with pure temporal processing playing an indirect role.In schizophrenia, deficits in monotonic and polytonic rhythmic perception did not contribute to prosodic processing dysfunction, and montonic rhythmic dysfunction and pitch perception did not covary. Conclusions: Exploring similarities between amusia and schizophrenia focused our characterization of prosodic processing as the function of sub-processes reflecting pitch and time perception,whichare prerequisite for prosodic processing. The uniqueness of dysprosodia in schizophrenia relative to other illnesses may be measured by idiosyncrasy in the pattern and magnitude of the sub-process task relationships.

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“…Despite such evidence, little is still known about such a capacity in symptomatically remitted patients with schizophrenia, although previous studies have revealed existing neuropsychological deficits in some cognitive functions including theory of mind (Herold et al, 2002; Mo et al, 2008), emotional reaction (Hoertnagl et al, 2014; Yalcin-Siedentopf et al, 2014) and prospective memory (Chen et al, 2015) in these patients during clinical remission. To address this issue, we recorded ERPs in 20 symptomatically remitted schizophrenia patients and 20 healthy controls while they performed the classic Stroop task.…”

Section: Introductionmentioning

confidence: 98%

Neurophysiological Evidence of Compensatory Brain Mechanisms Underlying Attentional-Related Processes in Symptomatically Remitted Patients with Schizophrenia

et al. 2017

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A recent electrophysiological study suggests existing compensatory brain activity as a mechanism for functional recovery of visual attention detection (the capacity for detecting external cues) in symptomatically remitted schizophrenia patients. Despite such evidence, little is known about other aspects of attentional-related processes in schizophrenia during clinical remission, such as their capacity to concentrate on the task at hands without being interfered by distracting information. To this end, we recorded event-related brain potentials (ERPs) from 20 symptomatically remitted schizophrenia patients and 20 healthy controls while they engaged in a classic Stroop task. Symptomatically remitted patients showed comparable Stroop interference to healthy controls, indicating a degree of functional recovery of such a capacity in these patients. On the neural level, the N450 over the fronto-central and central regions, a component of the ERPs related to conflict detection, was found across both groups, although patients presented a reduced N450 relative to healthy controls. By contrast, the amplitude of the sustained potential (SP) (600–800 ms) over the parieto-central and parietal regions, a component of the ERPs related to conflict resolution, was significantly increased in patients relative to healthy controls. Furthermore, such increased SP amplitude correlated positively with improved behavioral accuracy in symptomatically remitted patients with schizophrenia. These findings reveal that symptomatically remitted patients with schizophrenia increasingly recruited the parietal activity involving successful conflict resolution to offset reduced conflict detection. Therefore, this provides further insight into compensatory mechanisms potentially involving a degree of functional recovery of attentional-related processes in schizophrenia during clinical remission.

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Affective prosody perception in symptomatically remitted patients with schizophrenia and bipolar disorder

Cited by 19 publications

References 21 publications

Emotional Prosody Processing in Schizophrenic Patients: A Selective Review and Meta-Analysis

Emotional Prosody Processing in Schizophrenic Patients: A Selective Review and Meta-Analysis

What rhythmic perception and amusia can tell us about vocal social communication in schizophrenia

Neurophysiological Evidence of Compensatory Brain Mechanisms Underlying Attentional-Related Processes in Symptomatically Remitted Patients with Schizophrenia

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