Affective Disturbances in Alzheimer's Disease

Bungener, Catherine; Jouvent, Roland; Derouesné, Christian

doi:10.1111/j.1532-5415.1996.tb02939.x

Cited by 48 publications

(34 citation statements)

References 33 publications

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“…The amygdala has long been recognized as playing a role in emotional and affective experiences (Aggleton 1992). The amygdala sends extensive input to the ventral striatum (Zahm and Brog 1992;Kunishio and Haber 1994) (Joyce et al 1993) suggesting a region-specific dopaminergic vulnerability that may underlie some of the affective disturbances accompanying cognitive impairment in this disorder (Bungener et al 1996;Cadieux and Greve 1997).…”

Section: Discussionmentioning

confidence: 99%

Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain Comparison with D2 Receptor Expressing Neurons

Gurevich

Joyce

1999

Neuropsychopharmacology

404

286

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Section: Discussionmentioning

confidence: 99%

Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain Comparison with D2 Receptor Expressing Neurons

Gurevich

Joyce

1999

Neuropsychopharmacology

404

286

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“…However, dysthymia may have significant adverse effects on life in demented as well as in nondemented seniors. High dysthymia rates in dementia have been reported: Bungener et al 36 found a dysthymia rate of 8% in her neurology clinic sample of 118 patients with Alzheimer's disease and Migliorelli et al 24 cite a dysthymia rate of 28% of 103 patients from their neurology outpatient clinic (a very select group of patients). Migliorelli's group found that dysthymia was most pronounced early in the course of dementia and was correlated with a greater patient awareness of cognitive deficits.…”

Section: Dysthymiamentioning

confidence: 99%

“…8 Its prevalence of occurrence is likely stable throughout the course of dementia, 24 although, as with the lesser depressive syndromes above, contradictory reports cite both decreases 75 and increases 30,76 with the worsening of cognitive impairment. The cited prevalence varies widely, which may reflect differences in the sample populations or diagnostic approaches: Wragg and Jeste 77 review the literature and find prevalence rates of 10-20%, although some authors, such as Bungener et al 36 find that not one out of 118 patients in their neurology clinic sample had a major depressive disorder. Recent studies continue to embody this variability, depending on the methodology (and rating scale) used.…”

Section: Major Depressive Disordermentioning

confidence: 99%

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Depressive Syndromes in Dementia

Thorpe

Groulx

2001

Can. J. Neurol. Sci.

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. Overall goals and objectives, as well as procedures for consensus development, were based on the Canadian Medical Association guidelines for clinical practice guidelines, 1 a s described in the summary article by Patterson et al. 2 In this paper we present general information about the association between depression and dementia, then summarize various clinical presentations in dementia that have prominent depressive features, review diagnostic difficulties and lastly summarize treatment of depressive disorder in dementia in more detail, culminating in the main consensus conference recommendations.An initial Medline search was performed prior to the ABSTRACT: Background: Depressive syndromes in dementia are common, treatment is challenging and controlled intervention studies are small in number. The goal of this paper is to review known information about the etiology, epidemiology and treatment of these syndromes, as summarized at the recent Canadian Consensus Conference on Dementia. Methods: A number of Medline searches were performed (most recently updated in October 2000) using the subject categories dementia and depression, or apathy or emotional lability and other relevant articles were also reviewed. The background article was edited and amended at the Consensus Conference on Dementia. Final recommendations appearing in the summary article by Patterson et al were accepted by the group consensus process. Clinical discussion and informational updates were added for the current text by the authors. Results: Depressive syndromes, ranging in severity from isolated symptoms to full depressive disorders, increase in dementia. While clear-cut depressive disorder is increased in this population, sub-syndromal disorders are even more common and cause considerable distress. Antidepressant treatment may improve the quality of life in depressed, demented people, although it is less successful than in those without cognitive impairment and carries more risk of iatrogenic effects. Conclusions: Physicians should be alert to the presence of depressive syndromes in dementia. Depressive illness should be treated and, when necessary, referral should be made to an appropriate specialist. Treatment must minimize iatrogenic effects. Although there is some support for treatment of syndromes that do not meet criteria for depressive disorder or dysthymia, the first line of intervention in these situations should involve nonpharmacological approaches.RÉSUMÉ: Syndromes dépressifs dans la démence. Introduction: Les syndromes dépressifs sont fréquents dans la démence, leur traitement est un défi et il existe peu d'études d'intervention contrôlées. Le but de cet article était de revoir les connaissances sur l'étiologie, l'épidémiologie et le traitement de ces syndromes, conformément au résumé fait à la Conférence canadienne de consensus sur la démence. Méthodes: Des recherches dans Medline ont été effectuées (avec mise à jour en octobre 2000) utilisant la démence et la dépression comme catégorie de sujet ou l'apathie ou la labilité ...

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“…Castellon et al (2000) suggest that apathy is common in other neurological disease involving the CNS, and in fact we observed the same emotional profile in other diseases. Patients with Alzheimer's disease (Bungener et al, 1996a) or dystrophic myotony (Bungener et al, 1998) presented significantly more emotional deficit than paired controls.…”

mentioning

confidence: 99%

Emotional deficit as a neuropsychopathological disturbance in HIV infection

Bungener

Jouvent

2001

J Int Neuropsychol Soc

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We have been very interested in the article of Castellon et al. (2000) on the neuropsychiatric disturbances present in HIV-infection, which reports results very congruent with those published previously by our research group. Indeed, for many years we have studied psychopathological perturbations (depression and anxiety) as well as more specific emotional dimensions like emotional deficit and loss of control in HIV positive patients.

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Affective Disturbances in Alzheimer's Disease

Abstract: Affective changes were found frequently in AD patients, but no major affective disorder was found. The dimensional approach seems to be more appropriate than the categorical approach to describe the emotional disturbances in these patients.

Cited by 48 publications

References 33 publications

Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain Comparison with D2 Receptor Expressing Neurons

Distribution of Dopamine D3 Receptor Expressing Neurons in the Human Forebrain Comparison with D2 Receptor Expressing Neurons

Depressive Syndromes in Dementia

Emotional deficit as a neuropsychopathological disturbance in HIV infection

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