Despite increasing acceptance of interracial couples in the U.S., biases persist, and some evidence suggests that interracial couples may elicit a disgust response among people in the U.S. In a series of preregistered studies (Ntot = 3,367), we examine one possible explanation for this disgust response—sexual stereotyping of Black-White interracial couples. In Studies 1 and 2, participants explicitly identified interracial couples as being attributed deviant sexual stereotypes, and Study 3 completed the experimental causal chain by demonstrating that couples who are described with these deviant sexual stereotypes elicit disgust. Study 4 provided evidence that perceiving interracial relationships to be based on sexual fetishes statistically mediates the relation between interracial couples and disgust. Taken together, these findings indicate that interracial couples are stereotyped as sexually deviant, and that thinking of couples in terms of such deviant sexual stereotypes can produce a disgust response.