This paper aims to investigate the impact of social and psychological barriers on the negative intention of female students to be an entrepreneur and to analyze the mediating role of psychological barriers between social barriers and negative entrepreneurial intention. Total of 791 female students were surveyed from Bangladesh through an on-line questionnaire. Four hypotheses have been developed and tested on the total sample. Structural equation modeling (SEM) is used to measure the validity of the data and the relationship among the variables. The study endorsed that social barriers have a significant negative association with the negative intention toward entrepreneurship that indicates social barriers do not significantly reduce the entrepreneurial intention. Psychological barriers as mediating variable have a significant and positive relationship with social barriers and those barriers also have a significant positive effect on negative intention toward entrepreneurship. Psychological barriers partially mediate the relationship between social barriers and the intention toward entrepreneurship. Thus, social barriers through psychological barriers significantly influence the entrepreneurial intention and reduce the inclination of female students toward entrepreneurship. Contribution/Originality: This study originates unique findings that social barriers do not directly contribute to reducing the entrepreneurial intention, but psychological barriers significantly reduce the intention of the female students toward entrepreneurship. Besides, psychological barriers play a mediating role between social barriers and entrepreneurial intention. 1. INTRODUCTION Entrepreneurship is gaining more interest in almost all countries around the world. Both researchers and academicians agree that entrepreneurship is one of the most important factors that can contribute to economic development for both developed and developing economies (Temtime et al., 2004). The entrepreneur and entrepreneurial activities play a crucial role in the economic development of an individual, society as well as a country. The wheel of entrepreneurship starts from the intention of people towards entrepreneurship. Unfortunately, most of the students who want to start a business believe that there are lots of hurdles they have to face. These problems are more acute among female students. Wang and Wong (2004) found that factors like education, experience, gender and family background have a significant impact on the inclination of starting a new venture. The study also found that female students are less interested in entrepreneurship than males. They