Affect and Incident Participation Restriction in Adults With Knee Osteoarthritis

Vaughan, Molly; LaValley, Michael P.; Felson, David T.; Orsmond, Gael I.; Niu, Jingbo; Lewis, Cora E.; Segal, N.A.; Nevitt, Michael C.; Keysor, Julie J.

doi:10.1002/acr.23308

Cited by 9 publications

(4 citation statements)

References 41 publications

(71 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…16,17 Studies have also demonstrated associations between affect, depression, anxiety and participation restrictions in people with OA. 13,16,[18][19][20] Other factors reported to be associated with limited social participation include: joint pain, 17,21 being female or older, 21 having a spouse/partner, 13 lower levels of education and/or income, 13,17,21 reduced social networks and/or volunteer involvement, 13 as well as a lack of transportation options. 13 Community ambulation is complex because environmental conditions affect walking outside the home.…”

Section: Introductionmentioning

confidence: 99%

Factors associated with social participation and community ambulation in people with osteoarthritis: Findings from the Canadian Longitudinal Study on Aging

et al. 2022

View full text Add to dashboard Cite

Aim: Walking in the community allows participation in meaningful activities which positively influences self-rated health and quality of life. Our objective was to identify factors associated with social participation and community ambulation in a representative sample of Canadian adults with osteoarthritis (OA). Methods: Data were from >3800 participants in the Baseline Tracking Dataset of the Canadian Longitudinal Study on Aging with OA of the hip and/or knee. Outcomes included frequency of participation in 8 community-based activities (past year, social participation), and frequency walking outside the home (past 7 days, community ambulation). Explanatory variables (15 for social participation, 11 for community ambulation) established in previous literature were evaluated. Variables significant in univariate binary logistic regression models were entered into multivariable models.Results: Frequency of social participation was greater for females, and individuals with higher levels of education. Those who were younger, dissatisfied with life, and had difficulty walking 2-3 blocks were less likely to participate. Having fewer chronic conditions, being younger, being single/widowed and being interviewed in spring/ summer were associated with more frequent ambulation. Lower self-rated health, difficulty walking 2-3 blocks, pain and being female were associated with less frequent walking outside the home. Conclusion:Many factors influence frequency of social participation and community ambulation. The ability to walk short distances is positively associated with both outcomes. This important factor can and should be addressed clinically to improve health and quality of life in people with OA.

show abstract

Section: Introductionmentioning

confidence: 99%

Factors associated with social participation and community ambulation in people with osteoarthritis: Findings from the Canadian Longitudinal Study on Aging

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In both cases, they incorporate some domains of activity limitation and participation restriction presented in the ICF checklist. However, much of the recent researches on activity limitation and participation restriction in individuals with OA or RA has been focusing on specified body-part limitations after particular arthritic condition [ 16 – 18 ], hence little is known on the limitations existing in individuals with OA and RA, comparatively. Similarly, previous studies used few clinical samples with limited generalizability.…”

Section: Introductionmentioning

confidence: 99%

Activity limitation and participation restriction in Osteoarthritis and Rheumatoid arthritis: findings based on the National Health and Nutritional Examination Survey

Gikaro

Xiong

Feng

2022

BMC Musculoskelet Disord

View full text Add to dashboard Cite

Background Osteoarthritis (OA) and Rheumatoid arthritis (RA) are the most common joint diseases leading to chronic pain and disability. Given the chronicity and disabling nature of OA and RA, they are likely to influence full participation of individuals in the society. An activity limitation occurs when a person has difficulty executing an activity; a participation restriction is experienced when a person has difficulty participating in a real-life situation. The aim of this study was to examine the associations between OA and RA and the domains of activity limitation and participation restriction. Methods A cross-sectional study design comprised 3604 adults from the 2009 to 2018 National Health and Nutrition Examination Survey (NHANES). All participants aged ≥ 20 years with complete data were included. Activity limitation and participation restriction were assessed by reported difficulty in performing 14 tasks selected from Physical Functioning Questionnaire. Data on OA and RA were obtained from Medical Conditions Questionnaire. Weighted logistic regression model was used to examine the associations between OA and RA and the selected tasks. Results Over 36% of participants had limitations. Both OA (OR = 2.11) and RA (OR = 2.36) were positively associated with activity limitation and participation restriction (p < 0.001). Poor or fair health was associated with difficulty in physical functioning, with highest odds observed in leisure activities (OR = 2.05), followed by difficulty in attending social events (OR = 1.99), walking for a quarter mile (OR = 1.97), preparing meals (OR = 1.93) and walking up ten steps (OR = 1.92). Conclusion Adults with OA and RA had nearly similar odds of having activity limitations and participation restrictions. Difficulty in executing most activities of daily living (ADLs) has significant association with poor or fair health. Holistic interdisciplinary care to individuals with OA or RA focusing on ADLs and environmental factors may improve health status.

show abstract

“…Osteoarthritis (OA) is a chronic joint disease characterized by the progressive degradation of articular cartilage, accompanied by remodeling of the subchondral bone and consequent articular dysfunction. OA affects 20-25% of individuals aged >45 years and 37.4% of individuals aged ≥60 years old ( 1 , 2 ). Knee OA may cause severe pain, physical disability and reduced quality of life.…”

Section: Introductionmentioning

confidence: 99%

Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model

Zhang

Yang

et al. 2018

Int J Mol Med

View full text Add to dashboard Cite

The aim of the present study was to investigate potential alterations in the articular cartilage in a rat model of monosodium iodoacetate (MIA)-induced osteoarthritis (OA) with or without treatment with moderate treadmill exercise. A total of 30 male Sprague-Dawley rats were randomly divided into three groups (n=10), including the control, OA and OA with treadmill exercise (OAE) groups. Rats were evaluated upon completing the treadmill exercise program (speed, 18 m/min; 30 min/day; 5 days/week for 4 weeks). Interleukin (IL)-1β and IL-4 levels in the serum and intra-articular lavage fluid (IALF) were measured by ELISA. Alterations in articular cartilage and synovium were also evaluated by histology, immunohistochemistry, western blotting and reverse transcription-quantitative polymerase chain reaction. The results revealed that IL-1β in the serum and IALF decreased in the OAE group, whereas IL-4 increased, and histological evaluation indicated that the OAE group had a clear treatment response. However, the expression of type II collagen in the articular cartilage increased in the OAE group as compared with the OA group, whereas ADAMTS5 expression decreased. In contrast to light chain 3B (LC3B), the protein expression levels of BECLIN1 and sequestosome 1 (SQSTM1) were increased in the OA group. In addition, a significant increase was observed between OA and OAE groups in LC3B and SQSTM1 protein levels, whereas no change was observed in BECLIN1 levels between the OA and OAE groups in the superficial and deep zones. The results of western blotting demonstrated that LC3II was notably decreased in the OA group and partially increased in the OAE group. The mRNA expression levels of LC3B and SQSTM1 increased in the OA and OAE groups, with a significant difference observed between the two groups, while a concomitant decrease was detected in BECLIN1 levels. In conclusion, 30 min of treadmill exercise had an evident protective effect in the articular cartilage of rats with MIA-induced OA and may promote autophagy in the articular cartilage.

show abstract

Affect and Incident Participation Restriction in Adults With Knee Osteoarthritis

Abstract: Low positive and high negative affect, both alone and in combination, increase the risk of participation restriction among adults with knee OA. Efforts aimed at preventing participation restriction in this population should consider these mood states.

Cited by 9 publications

References 41 publications

Factors associated with social participation and community ambulation in people with osteoarthritis: Findings from the Canadian Longitudinal Study on Aging

Factors associated with social participation and community ambulation in people with osteoarthritis: Findings from the Canadian Longitudinal Study on Aging

Activity limitation and participation restriction in Osteoarthritis and Rheumatoid arthritis: findings based on the National Health and Nutritional Examination Survey

Alterations of autophagy in knee cartilage by treatment with treadmill exercise in a rat osteoarthritis model

Contact Info

Product

Resources

About