AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p

Zeng, Tao; Wang, Dan; Chen, Juan; Chen, Ke; Yu, Gangfeng; Chen, Qiuxu; Liu, Yuyang; Yan, Shaoyin; Zhū, Lìyǐng; Zhou, Huihao; Huang, Aiping; Tang, Hua

doi:10.1016/j.yexcr.2017.12.016

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…The GEO database is a public database of microarray profile founded by the National Center for Biotechnology Information and provides access to high-throughput screening of abnormally expressed genes in cancerous tissues (7). Numerous studies have explored microarray data profiling (8,9). However, although reliable molecular biomarkers have been clinically observed in patients with HCC, the underlying molecular mechanisms of HCC remain to be clarified.…”

Section: Introductionmentioning

confidence: 99%

Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases

et al. 2019

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Hepatocellular carcinoma (HCC) ranks the third major cause of cancer-associated mortality globally. Numerous studies have attempted to elucidate the underlying mechanisms of HCC using various biomarkers. In the present study, two expression profiles datasets from Gene Expression Omnibus (GSE76427 and GSE84402) and data associated with liver cancer samples from The Cancer Genome Atlas (TCGA) were downloaded for integrated analysis. Five differentially expressed genes (DEGs) exhibiting high expression, including ubiquitin-conjugating enzyme 2C (UBE2C), topoisomerase II α, pituitary tumor transforming gene 1, glypican-3 and polycomb-repressive complex 1, were selected and considered as candidate genes. Enrichment analysis demonstrated that these genes were associated with Gene Ontology terms of cellular components and molecular functions, including regulation of apoptosis, stabilization of p53 and Anaphase Promoting Complex/Cyclosome (APC/C) (APC/C:Cdc20)-mediated degradation of Securin. The expression profiles of these genes in HCC, other human malignancies and different human HCC cell lines were validated using GSE14520, GSE3500 and TCGA data. The results confirmed the upregulation of UBE2C in tissues from patients with HCC or other human malignancies and human liver cancer cell lines, compared with the expression levels in the corresponding adjacent non-tumor tissues and cell lines, respectively. Patients with HCC who exhibited an increased messenger RNA level of UBE2C exhibited a significantly shorter survival time. The results of the present study suggest that the overexpression of UBE2C may be used as a novel prognostic biomarker of HCC.

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Section: Introductionmentioning

confidence: 99%

Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases

et al. 2019

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“…Although many studies 126 , 127 , 128 have confirmed that the biological function of lncRNA can be mutually regulated with miRNA, and the regulatory axis of lncRNA-miRNA-mRNA has been proved to exist in other tumors, no complete regulatory network has been established in HCC. In order to fully grasp the regulatory role of lncRNA in the development of HCC, it is important to explore the regulatory network of miRNA–lncRNA–mRNA in HCC and the other undiscovered signaling pathways.…”

Section: Conclusion and Perspectivementioning

confidence: 99%

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

et al. 2021

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Thousands of long non-coding RNAs (lncRNAs) have been discovered in human genomes by gene chip, next-generation sequencing, and/or other methods in recent years, which represent a significant subset of the universal genes involved in a wide range of biological functions. An abnormal expression of lncRNAs is associated with the growth, invasion, and metastasis of various types of human cancers, including hepatocellular carcinoma (HCC), which is an aggressive, highly malignant, and invasive tumor, and a poor prognosis in China. With a more in-depth understanding of lncRNA research for HCC and the emergence of new molecular-targeted therapies, the diagnosis, treatment, and prognosis of HCC will be considerably improved. Therefore, this review is expected to provide recommendations and directions for future lncRNA research for HCC.

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The emergence of long non-coding RNAs in hepatocellular carcinoma: an update

et al. 2018

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Hepatocellular carcinoma (HCC) accounting for roughly 90% of all primary liver neoplasms is the sixth most frequent neoplasm and the second prominent reason of tumor fatality worldwide. As regulators of diverse biological processes, long non-coding RNAs (lncRNAs) are involved in onset and development of neoplasms. With the continuous booming of well-featured lncRNAs in HCC from 2016 to now, we reviewed the newly-presented comprehension about the relationship between lncRNAs and HCC in this study. To be specific, we summarized the overview function and study tools of lncRNAs, elaborated the roles of lncRNAs in HCC, and sketched the molecule mechanisms of lncRNAs in HCC. In addition, the application of lncRNAs serving as biomarkers in early diagnosis and outcome prediction of HCC patients was highlighted.

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AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p

Cited by 3 publications

References 53 publications

Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases

Identification of the potential therapeutic target gene UBE2C in human hepatocellular carcinoma: An investigation based on GEO and TCGA databases

Comprehensive biological function analysis of lncRNAs in hepatocellular carcinoma

The emergence of long non-coding RNAs in hepatocellular carcinoma: an update

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