Aetiology of Oral Cancer in the Sudan

Ahmed, Hussain Gadelkarim

doi:10.5037/jomr.2013.4203

Cited by 31 publications

(28 citation statements)

References 58 publications

(52 reference statements)

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“…Tobacco-specific nitrosamines (TSNA) levels in Sudanese Toombak were found to be unusually high compared to the reported levels in any other SLT. The etiologic association between Toombak use and oral cancer has been investigated by several studies [5–8]. …”

Section: Introductionmentioning

confidence: 99%

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

et al. 2017

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BackgroundOral cancer is a preventable disease. Its occurrence is mostly due to lifestyle. In Sudan, the use of smokeless tobacco (Toombak) has long been linked to oral cancer. Knowledge of the signs and symptoms of oral cancer may well aid in early diagnosis and treatment. This is bound to result in increasing survival rates, as well as reducing the oral cancer burden on the society. This study aimed to assess oral cancer awareness regarding knowledge of signs, symptoms, risk factors and sources of the information. Furthermore, it attempts to evaluate attitudes towards oral cancer screening and any previous experience of screening, amongst dental patients attending University of Science and Technology (UST) Dental Teaching Hospital. Omdurman, Sudan.MethodsA hospital based cross-sectional study, interviewer-administered questionnaire was conducted amongst 500 adult patients attending the UST Dental Hospital during 2015.ResultsA total of 57.7% (286) of the individuals demonstrated good knowledge of signs and symptoms, whereas 49% (139) expressed good knowledge of risk factors of oral cancer. For the majority of the individuals 66.1% (290), the most common source of information about oral cancer was from the media, while 33.9% individuals (149), obtained knowledge from direct contact of health workers. The overwhelming majority, 93.2% (466) never screened for oral cancer despite their positive attitude towards it 66.4% (332). Knowledge of risk factors associated significantly with those reported positive attitude towards oral cancer screening and those reported direct contact with health workers as a source of information, (p ≤ 0.001). Moreover, females and those living in urban districts scores higher than their counterpart in knowledge of risk factor of oral cancer. In addition, those employed 58.6% (280) and 62.8% (164) with correct believes about oral cancer showed significant association with positive knowledge of signs and symptoms (p ≤ 0.05).ConclusionsAwareness levels, knowledge of risk factors and identifying early signs and symptoms of oral cancer necessitate the need for more structured preventive programs using media. Dentists and health workers should do more because they have a pivotal role in early diagnosis by performing oral cancer screening, raising levels of knowledge and in rectifying misconceptions about oral cancer. This would entail a reduction in high rates of morbidity and mortality associated with oral cancer.Electronic supplementary materialThe online version of this article (doi:10.1186/s12903-017-0351-z) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

et al. 2017

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“…Oral cancer is extremely increasing in the Sudan, particularly among men [13]. Several studies have linked the etiology of oral cancer to the oral use of Toombak (tobacco specific nitrose amine rich tobacco) [14,15] and HPV infection [4][5][6][7][8][9][10][11][12][13][14][15][16]. In Sudan the prevalence of HPV was reported to be 65% [17].…”

Section: Introductionmentioning

confidence: 99%

“…The HPV types 6, 11, 40, 42, 43, 44, -53, 54, 61, 72, and 81, regarded as low-risk Human Papillomaviruses (LR-HPV) [5]. Infections with HPV have been found in a number of body sites, including the skin, larynx, tracheobronchial mucosa, nasal cavity, paranasal sinus, esophagus and oral cavity [6][7][8][9]. Infection with HR_HPV has been regarded as a potential risk for the development of oral squamous cell carcinoma (OSCC).…”

Section: Introductionmentioning

confidence: 99%

Cytological Study of Oral Human Papillomavirus (Hpv) Infection among Gathered Shish Smokers

Alobaid¹,

Ebnaof²,

Ahmed³

et al. 2017

JDHODT

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“…11,12 Assessment of cancer awareness level among a particular community setting is important step toward cancer prevention and control. Such initiatives give the policy makers and health care providers a chance to understand the importance of the interventions and do what is possible to get the desired outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…Oral cells were used to test for this mutation, since a number of studies have clarified the strong causal effects of tobacco in etiology of oral cancerous and precancerous lesions. 12 This in addition to the fact that the relationship between PTEN gene mutation and the development of oral cancer is well established. 8 Although there are numerous studies on the etiology of oral cancer but the exact pathogenesis still unclear.…”

mentioning

confidence: 99%

Molecular Screening for PTEN Gene Mutation Among Cigarette Smokers and Assessment of Knowledge of the Link Between Tobacco Use, and Cancer Among Saudi Population.

Alshammari¹

2017

UHOD

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Tobacco use accounts for at least 30% of all cancer deaths, and 87% of lung cancer deaths. Therefore, the aim of this study was to screen for Phosphatase and Tensin homolog (PTEN) gene mutation among cigarette smokers and to assess population awareness towards tobacco carcinogenicity among Saudi population. This is a cross-sectional survey involved 2099 Saudi civilians living in Northern Kingdom of Saudi Arabia (KSA). PTEN gene mutation molecular detection was performed for 100 tobacco users, DNA extracted from buccal cells. Out of the 2099, participants, 669/2099(31.8%) were smokers and 1430/2099 (68.2%) were non-smokers. Data regarding smoking type and status were available for 399 cases of whom, 229/399 (57.4%) were currently cigarette smokers, 36/399 (9.2%) were currently shisha smokers and 134/399 (33.6%) were ex-smokers. PTEN gene mutations were identified among two current smokers. Cigarette smoking is a public concern in KSA, which requires control strategies. There is no significant correlation between PTEN gene mutation and cigarette smoking. gen mutasyonları, halen sigara içmekte olan iki kişide tespit edildi. Sigara kullanımı Suudi Arabistan'da önemli halk sağlığı sorunudur ve kontrol stratejileri gerektirmektedir. PTEN gen mutasyonu ve sigara kullanımı arasında anlamlı bir korelasyon saptanmamıştır.

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Aetiology of Oral Cancer in the Sudan

Cited by 31 publications

References 58 publications

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

Oral Cancer Awareness Among Dental Patients in Omdurman, Sudan: a cross-sectional Study

Cytological Study of Oral Human Papillomavirus (Hpv) Infection among Gathered Shish Smokers

Molecular Screening for PTEN Gene Mutation Among Cigarette Smokers and Assessment of Knowledge of the Link Between Tobacco Use, and Cancer Among Saudi Population.

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