Aetiology of acute diarrhoea in children in Shanghai, 2015–2018

Chang, Hailing; Guo, Jiayin; Wei, Zhongqiu; Huang, Zheng; Wang, Chuning; Qiu, Yue; Xu, Xuebin; Zeng, Mei

doi:10.1371/journal.pone.0249888

Cited by 14 publications

(13 citation statements)

References 30 publications

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“…Rotavirus A was frequently associated with viral diarrhea in children. This result was similar to previous studies 9,13 . Inhibiting rotavirus disease is a national and global priority.…”

Section: Discussionsupporting

confidence: 92%

“…This result was similar to previous studies. 9,13 Inhibiting rotavirus disease is a national and global priority. And considering that the primary virus causing diarrhea in children almost worldwide is still rotavirus, 14 we still strongly recommend the inclusion of rotavirus vaccine in the national immunization program.…”

Section: Discussionmentioning

confidence: 99%

“…And the prevalence of diarrhea viruses among age groups was compared. Viral agents were more likely to be identified in the group of 0-12 (n = 129) and [13][14][15][16][17][18][19][20][21][22][23][24] (n = 121) months. Also, with aging, the number of cases decreased gradually.…”

Section: Prevalence Of Virusesmentioning

confidence: 99%

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Viral infection among children under the age of 5 with diarrhea in Shenyang from 2018 to 2020: A hospital‐based study

Dong

Ying

Chai

et al. 2021

Journal of Medical Virology

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Diarrhea is one of the leading causes of death among children, especially in the age under 5, but few studies are available on viral diarrhea in Shenyang. To understand the infection status and the relevant epidemiological characteristics of viral diarrhea and to fill gaps of the distribution of viruses across Shenyang in children under the age of 5 with diarrhea, from 2018 to 2020, stool specimens of children with diarrhea aged 0-59 months and surveillance data were collected in Sentinel Hospital of Shenyang. Specimens were then tested to determine the type of viruses, the seasonal and spatial patterns for major viruses were determined. Viruses were identified in 47.9% of the 897 samples from children with diarrhea. The main viruses of stool samples were rotavirus (16.9%, predominant type G9P[8]), calicivirus (14.7%), adenovirus (11.8%), and astrovirus (4.5%). Viral infections were mainly detected in the age of 0-12 months. In the area of Shenyang, Huanggu had the most cases (198, 22.1%), followed by Dadong (137, 15.3%) and Hunnan (135, 15.1%). The positive rate of viruses varied among patients of different ages, seasons, and regions. Public health entities and the government should develop corresponding measures for different age groups, seasons, and regions.

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“…Rotavirus A was frequently associated with viral diarrhea in children. This result was similar to previous studies 9,13 . Inhibiting rotavirus disease is a national and global priority.…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Viral infection among children under the age of 5 with diarrhea in Shenyang from 2018 to 2020: A hospital‐based study

Dong

Ying

Chai

et al. 2021

Journal of Medical Virology

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“…Rotavirus and calicivirus were the predominant viral agents. This result was similar to previous studies [9,13]. It's worth noting that the number of cases of rotavirus had a downtrend but the calicivirus had an upward trend.…”

Section: Discussionsupporting

confidence: 91%

Etiological and Epidemiological of Viral Diarrhea Among Children Under the Age of Five in Shenyang From 2018 to 2020

Dong

Chai

et al. 2021

Preprint

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Diarrhea is one of the leading causes of death among children, especially in the age under five, but little data are available on the etiology of viral diarrhea in Shenyang. To understand the infection status and the relevant epidemiological characteristics of viral diarrhea and to fill gaps of how the distribution of viruses change across Shenyang in children under the age of five with diarrhea, stool specimens of children with diarrhea aged 0-59 months and surveillance data was collected from Sentinel Hospital of Shenyang. Rotavirus, calicivirus, adenovirus, and astrovirus 4 viruses were then analyzed, and the proportion of children who tested positive for each pathogen was calculated and seasonal and spatial patterns for major organisms were determined. Viruses were identified in 47.9% of the 897 samples from children with diarrhea. The main viruses of stool samples were rotavirus (16.9%, predominant type G9P[8]), calicivirus (14.7%, norovirus, predominant type GII ), adenovirus (11.8%), and astrovirus (4.5%). Viral infections were mainly detected in the age of 0-12 months. In the area of Shenyang, Huanggu has the most cases (198, 22.1%), followed by Dadong (137, 15.3%) and Hunnan (135, 15.1%). The positive rate of viruses in patients of different ages, seasons, and regions was not same. Public health entities and the government should develop corresponding measures for different age groups, seasons, and regions.

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“…A large national-based AGE surveillance study conducted in China between 2009 and 2018 revealed norovirus and rotavirus as the leading agents detected in patients aged <5 years, and norovirus was detected in 32.2% of 58,620 analyzed samples [ 35 ]. Other studies performed elsewhere have found norovirus prevalence varying from 15% to 21% [ 33 , 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Virological and Epidemiological Features of Norovirus Infections in Brazil, 2017–2018

Sarmento

Andrade

Miagostovich

et al. 2021

Viruses

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Noroviruses are considered an important cause of acute gastroenteritis (AGE) across all age groups. Here, we investigated the incidence of norovirus, genotypes circulation, and norovirus shedding in AGE stool samples from outpatients in Brazil. During a two-year period, 1546 AGE stool samples from ten Brazilian states were analyzed by RT-qPCR to detect and quantify GI and GII noroviruses. Positive samples were genotyped by dual sequencing using the ORF1/2 junction region. Overall, we detected norovirus in 32.1% of samples, with a massive predominance of GII viruses (89.1%). We also observed a significant difference between the median viral load of norovirus GI (3.4×105 GC/g of stool) and GII (1.9×107 GC/g). The most affected age group was children aged between 6 and 24 m old, and norovirus infection was detected throughout the year without marked seasonality. Phylogenetic analysis of partial RdRp and VP1 regions identified six and 11 genotype combinations of GI and GII, respectively. GII.4 Sydney[P16] was by far the predominant genotype (47.6%), followed by GII.2[P16], GII.4 Sydney[P31], and GII.6[P7]. We detected, for the first time in Brazil, the intergenogroup recombinant genotype GIX.1[GII.P15]. Our study contributes to the knowledge of norovirus genotypes circulation at the national level, reinforcing the importance of molecular surveillance programs for future vaccine designs.

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Aetiology of acute diarrhoea in children in Shanghai, 2015–2018

Cited by 14 publications

References 30 publications

Viral infection among children under the age of 5 with diarrhea in Shenyang from 2018 to 2020: A hospital‐based study

Viral infection among children under the age of 5 with diarrhea in Shenyang from 2018 to 2020: A hospital‐based study

Etiological and Epidemiological of Viral Diarrhea Among Children Under the Age of Five in Shenyang From 2018 to 2020

Virological and Epidemiological Features of Norovirus Infections in Brazil, 2017–2018

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