Aetiology, morphology and body composition of infants born small for gestational age

Lapillonne, Alexandre; Peretti, Noël; Ho, P. S.; Claris, Olivier; Salle, B

doi:10.1111/j.1651-2227.1997.tb18406.x

Cited by 54 publications

(31 citation statements)

References 20 publications

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“…We have shown previously an increased activity of MVM LPL in placentas from pregnancies complicated by maternal insulin-dependent diabetes mellitus (IDDM) (27) associated with accelerated fetal growth and large fat depots (28) and a decreased activity in pregnancies delivering preterm fetuses with intrauterine growth restriction (IUGR), a condition typically characterized by reduced fetal fat depots (27,29). In the same study, we demonstrated increased placental L-FABP expression in gestational diabetes mellitus and IDDM (27).…”

mentioning

confidence: 58%

Gestational and hormonal regulation of human placental lipoprotein lipase

Magnusson-Olsson

Hamark

Ericsson

et al. 2006

Journal of Lipid Research

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The fetal demand for FFA increases as gestation proceeds, and LPL represents one potential mechanism for increasing placental lipid transport. We examined LPL activity and protein expression in first trimester and term human placenta. The LPL activity was 3-fold higher in term (n 5 7; P , 0.05) compared with first trimester (n 5 6) placentas. The LPL expression appeared lower in microvillous membrane from first trimester (n 5 2) compared with term (n 5 2) placentas. We incubated isolated placental villous fragments with a variety of effectors [GW 1929, estradiol, insulin, cortisol, epinephrine, insulin-like growth factor-1 (IGF-1), and tumor necrosis factor-a] for 1, 3, and 24 h to investigate potential regulatory mechanisms. Decreased LPL activity was observed after 24 h of incubation with estradiol (1 mg/ml), insulin, cortisol, and IGF-1 (n 5 12; P , 0.05). We observed an increase in LPL activity after 3 h of incubation with estradiol (20 ng/ml) or hyperglycemic medium plus insulin (n 5 7; P , 0.05).

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mentioning

confidence: 58%

Gestational and hormonal regulation of human placental lipoprotein lipase

Magnusson-Olsson

Hamark

Ericsson

et al. 2006

Journal of Lipid Research

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“…But are SGA children 'normal'? They form a heterogeneous group [8] with various pathologic determinants [27]. Certain reports [15] have noted no apparent GH deficiency in SGA children, while others [28] have shown a reduced rate of GH secretion associated with an abnormal pattern of secretion and reduced levels of insulin-like factor I (IGF-I) and IGF-binding protein-3.…”

Section: Discussionmentioning

confidence: 99%

Catch-Up Growth in 166 Small-for- Gestational Age Premature Infants Weighing Less than 1,000 g at Birth

Monset-Couchard

Bethmann

2000

Neonatology

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Catch-up growth was studied in 166 children born with an extremely low birth weight (<1,000 g) and small-for-gestational age (SGA, <10th percentile birth weight for gestational age). Of these children 159 were followed up for between 4 and 18 years (median 9 years). Group A, SGA <10th percentile of Lubchenco curves only; group B, <10th percentile of Mamelle’s curves but >5th percentile, and group C, <5th percentile of Mammelle’s curves. Catch-up growth was considered to be achieved when height, weight, and head circumference (HC) reached –2 SD of French reference data and remained above this limit afterwards. Catch-up growth in height was achieved in 126/156 children or 81% (group A 88%; group B 84%; group C 74%), before 3 years of age in 100/127 (78%). Seven children below –2 SD received growth hormone (1 child who caught up was excluded from the results). Catch-up growth in weight was achieved in 126/159 children or 79% (group A 86%; group B 82%; group C 73%), before 3 years of age in 87/126 (69%). Catch-up growth in HC was achieved in 126/156 or 81% (group A 78%; group B 92%; group C 77%), before 3 years of age in 102/127 (80%). Overall catch-up growth was achieved for all three parameters in 65% of children, two of three parameters in 19%, and one of three parameters in 8%. Eleven children never caught up on any parameter. While weight is a lesser concern and HC is not liable to intervention, a greater number of short children might benefit from growth hormone therapy.

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“…The children included in the study group all had a late-onset (mid-second -third trimester) IUGR. Diagnosis was verified clinically and/or by ultrasound, and all showed signs of the asymmetric type of IUGR (Lapillone, Peretti, Ho, & Salle, 1997). Leitner et al (2000) discerned that the majority of children in this study had suffered a (placental) vascular-induced growth restriction.…”

Section: Exclusion Criteriamentioning

confidence: 99%

Prenatal diagnosis and management of intrauterine growth restriction: A long‐term prospective study on outcome and maternal stress

Geva

Eshel

Leitner

et al. 2005

Infant Mental Health Journal

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This study examines long-term effects of antenatal management of intrauterine growth restriction (IUGR) on developmental outcome and on maternal coping using a prospective cross-sectional design. Sixty-nine families were evaluated using psychological testing and risk questionnaires. The effects of timing of diagnosis (prenatal/perinatal) and of pregnancy management [induction of labor (IL)/conservative management (CM)/none, i.e., diagnosed-at-birth (DaB)] on maternal stress were tested at 6 years' postbirth. In general, prenatal management protocols of IUGR were efficient in preventing major disabilities; however, 49% of the variance in maternal stress at 6 years' postbirth could be attributed to the child's presenting behavior and to pregnancy management of IUGR condition. Mothers who received CM treatment reported being more stressed by their child's poor emotional adjustment (ps < .01-.002) and distractibility (p < .029), and to have more difficulty in accepting them (p < .01). Prenatal psychological consultation to better handle stress for parents whose fetus is diagnosed with IUGR is recommended, particularly when pregnancy is managed conservatively and familial-educational resources are low.

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Aetiology, morphology and body composition of infants born small for gestational age

Cited by 54 publications

References 20 publications

Gestational and hormonal regulation of human placental lipoprotein lipase

Gestational and hormonal regulation of human placental lipoprotein lipase

Catch-Up Growth in 166 Small-for- Gestational Age Premature Infants Weighing Less than 1,000 g at Birth

Prenatal diagnosis and management of intrauterine growth restriction: A long‐term prospective study on outcome and maternal stress

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